Sodium propyl hydroxybenzoate

Synonyms E217 propyl 4-hydroxybenzoate sodium salt sodium propyl hydroxybenzoate soluble propyl hydroxybenzoate. 

Preservative 217 Sodium propyl p-hydroxybenzoate 10 35th Series 2001... 

Synonyms. Sodium Propylparaben Soluble Propyl Hydroxybenzoate. Proprietary Name. Nipasol M Sodium C,oHnNa03 = 202.2 CAS—35285-69-9... 

E215 Sodium ethyl p-hydroxybenzoate E216 Propyl p-hydroxybenzoate E217 Sodium propyl p-hydroxybenzoate E218 Methyl p-hydroxybenzoate E219 Sodium methyl p-hydroxybenzoate2... 

Sodium 4-propoxycarbonylphenoxide Sodium propyl 4-hydroxybenzoate Sodium propyl p-hydroxybenzoate. See Sodium propylparaben Sodium propylparaben CAS 35285-69-9 EINECS/ELINCS 252-488-1 INS217 E217... 

Boil about 01 g with 50 ml of N sodium hydroxide for thirty minutes under reflux. Cool, add 50 ml of 01N bromine and 10 ml of concentrated hydrochloric acid. Allow to stand for half an hour, shaking repeatedly during the first fifteen minutes, add 2 g of potassium iodide and titrate the liberated iodine with O IN sodium thiosulphate. 1 ml of 0 1 N bromine == 0 002536 g methyl hydroxybenzoate, CgHgOa 0 002902 g sodium salt of the methyl ester 0 003003 g propyl hydroxybenzoate, C10H12C3, and 0 003370 g sodium salt of the propyl ester. 

C12 to C20, primarily Ci6 to ( is), used as surface lubricants in the manufacture of food-contact articles. The method, which uses ethyl palmitate (Eastman Chemicals No. 1575 Red Label) as an internal standard, has been validated at 200 ppm total FAME [185]. Other FAME standards (methyl palmitate, methyl stearate, methyl oleate, methyl linoleate and methyl linolenate) are available (Applied Science Laboratories) [116], Worked out examples of additive determinations are given in the Food Additives Analytical Manual [116], which also describes a great many of indirect food additives, such as BHA, BHT, TBHQ, l-chloro-2-propanol, DLTDP, fatty acid methyl esters, w-heptyl-p-hydroxybenzoate, propyl-gallate, sodium benzoate, sodium stearoyl-2-lactylate, sorbitol and phenolic antioxidants. EPA methods 606 and 8060 describe the CGC separation of phthalate esters (direct injection) (cf. Figure 4.2). 

Annex III lays down the conditions of use for permitted preservatives and antioxidants, with lists of foods and maximum levels in each case. Part A lists the sorbates, benzoates and p-hydroxybenzoates, E 200-E 219 part B lists sulphur dioxide and the sulphites, E 220-E 228 part C lists other preservatives with their uses, including nisin, dimethyl dicarbonate and substances allowed for surface treatment of certain fruits, E 249 potassium nitrite, E 250 sodium nitrite, E 251 sodium nitrate and E 252 potassium nitrate, E 280-E 283 propionic acid and the propionates part D lists the antioxidants E 320 butylated hydroxyanisole (BHA), E 321 butylated hydroxytoluene (BHT), E 310 propyl gallate, E 311 octyl gallate, E 312 dodecyl gallate, E 315 eiythorbic acid and E 316 sodium erythorbate. 

There is a recent trend towards simultaneous CE separations of several classes of food additives. This has so far been applied to soft drinks and preserved fruits, but could also be used for other food products. An MEKC method was published (Lin et al., 2000) for simultaneous separation of intense sweeteners (dulcin, aspartame, saccharin and acesulfame K) and some preservatives (sorbic and benzoic acids, sodium dehydroacetate, methyl-, ethyl-, propyl- and isopropyl- p-hydroxybenzoates) in preserved fruits. Ion pair extraction and SPE cleanup were used prior to CE analysis. The average recovery of these various additives was 90% with good within-laboratory reproducibility of results. Another procedure was described by Frazier et al. (2000b) for separation of intense sweeteners, preservatives and colours as well as caffeine and caramel in soft drinks. Using the MEKC mode, separation was obtained in 15 min. The aqueous phase was 20 mM carbonate buffer at pH 9.5 and the micellar phase was 62 mM sodium dodecyl sulphate. A diode array detector was used for quantification in the range 190-600 nm, and limits of quantification of 0.01 mg/1 per analyte were reported. The authors observed that their procedure requires further validation for quantitative analysis. 

A paired-ion, reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of sweeteners (dulcin, saccharin-Na, and acesulfame-K), preservatives (sodium dehydroacetate, SA, salicyclic acid, BA, succinic acid, methyl-para-hydroxybenzoic acid, ethyl-para-hydroxybenzoic acid, n-propyl-para-hydroxybenzoic acid, n-butyl-para-hydroxybenzoic acid, and isobutyl-para-hydroxybenzoic acid), and antioxidants (3-tertiary-butyl-4-hydroxyanisole and tertiary-butyl-hydroquinone). A mobile phase of acetonitrile-50 ml aqueous tr-hydroxyisobutyric acid solution (pH 4.5) (2.2 3.4 or 2.4 3.6, v/v) containing 2.5 mM hexadecyltrimethylammonium bromide and a Clg column with a flow rate of 1.0 ml/min and detection at 233 nm were used. This method was found to be very reproducible detection limits ranged from 0.15 to 3.00 p,g. The retention factor (k) of each additive could be affected by the concentrations of hexadecyltrimethylammonium bromide and a-hydroxyisobu-tyric acid and the pH and ratio of mobile phase. The presence of additives in dried roast beef and sugared fruit was determined. The method is suitable for routine analysis of additives in food samples (81). 

Prochlorperazine Edisylate Prochlorperazine edisylate is not compatible with sodium chloride solutions containing methyl hydroxybenzoate and propyl hydroxy-benzoate as preservatives, but is compatible with solutions containing benzyl alcohol. Prochlorperazine edisylate salts are incompatible with a number of drugs such as aminophylline, amphotericin, ampicillin sodium, some barbiturates, ben-zylpenicillin salts, calcium gluconate, cefmetazole sodium, cephalothin sodium, chloramphenicol sodium succinate, chlorothiazide sodium, chloramphenicol, morphine sulfate containing phenol, magnesium trisilicate mixture, sodium succinate, chlorothiazide sodium, dimenhydrinate, heparin sodium, hydrocortisone sodium succinate, midazolam hydrochloride, and some sulfonamides.166... 

Phenol acids are phenols in which there is also a carboxylic acid group attached to the benzene ring. They include salicylic acid (ortho-hydroxybenzoic acid) and para-hydroxy-benzoic acid (Figure 25.8). Acetylsalicylic acid (aspirin) and sodium salicylate are derivatives of salicylic acid. Like phenol, they have antipyretic and analgesic properties. The methyl, ethyl and propyl esters of para-hydroxybenzoic acid (parabens) are used as preservatives in pharmaceuticals, cosmetics and foodstuffs. 

Benzoic xid, 4-hydroxy-, propyl ester, sodium salt Caswell No. 714A EINECS 252488-1 EPA Pesticide Chemical Code 061204 4-Hydroxybenzoic acid, propyl ester, sodium salt Nipasol M Sodium Parasept Propyl p-hydroxybenzoate, sodium salt Propylparaben sodium Propylparaben, sodium salt Sodium 4-propoxy-carbonylphenoxide Sodium propylparaben. Preservative, bactericide, fungicide for pharmaceuticals, cosmetics, foods, medicinal preparations, industrial applications. Laboratories Ltd Nipa. 

See Potassium propylparaben Propyl-4-hydroxybenzoate, sodium salt Propyl-p-hydroxybenzoate, sodium salt. See Sodium propylparaben... 

Propyl parasept 4-hydroxybenzoic acid propyl ester Propyl parahydroxybenzoate Propylparaben Nipasol M E 216 (sodium salt E 217). 

Applications. In many countries the methyl, ethyl and n-propyl esters of p-hydroxybenzoic acid, as well as their sodium salts, are permitted for preservation of some foods. The maximum permissible quantity is around 0.1%. In the USA methyl- and propyl-paraben are considered GRAS. The maximum permissible quantity is 0.1%. Their main field of use is not food preservation but the preservation of pharmaceutical and cosmetic fat emulsions. The usage of the butyl ester is not allowed in food applications. 

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