Propyl parahydroxybenzoate

Propyl parahydroxybenzoate Antiseptic, preservative, stabilizer iv, im, sc, ic, other inj... 

BP Propyl hydroxybenzoate JP Propyl parahydroxybenzoate PhEur Propylis parahydroxybenzoas USPNF Propylparaben... 

CAS 94-13-3 EINECS/ELINCS 202-307-7 FEMA 2951 INS216 E216 Synonyms 4-Hydroxybenzoic acid, propyl ester p-Hydroxybenzoic acid, propyl ester p-Hydroxypropyl benzoate Propyl 4-hydroxybenzoate n-Propyl p-hydroxybenzoate Propyl p-hydroxybenzoate Propyl parahydroxybenzoate Propyl parasept Classification Organic ester Definition Ester of n-propyl alcohol and p-hydroxybenzoic acid Empirical C10H12O3... 

Propylparaben sodium Propylparaben sodium salt. See Sodium propylparaben Propyl parahydroxybenzoate Propyi Parasept NF/FCC, Propyl parasept. See Propylparaben Propyl pelargonate CAS 6513-03-7... 

Synonyms 4-Hydroxybenzoic acid propylester propyl-p-hydroxybenzoate propagtn propyl parahydroxybenzoate... 

The pH of antacid suspensions is between 7.7 and 8.2. This pH range is very unfavourable for the stability and effectiveness of methyl parahydroxybenzoate and no other preservatives are available for that pH range. Propyl parahydroxybenzoate can be added but additional measures are needed to achieve a reasonable shelf life the use of raw materials with a low bioburden, preventing contamination during preparation, storage in the fridge, small bottles, limited usage period. 

Disadvantages of both methyl and propyl parahydroxybenzoate are allergic reactions and an unpleasant tingling sensation experienced by several patients when the solution contacts their tongue. 

Most ready-to-use liquid preparations for nebuUsatimi are supplied in single-dose vials and according to the European Pharmacopoeia, they have to be sterile and preservative-free. When they are supplied in multidose containers, they have to be sterile if they do not contain an antimicrobial preservative or when the preparation does not have adequate antimicrobial properties itself. The multidose containers have to be designed to prevent microbial contamination of their contents during storage and use. A wide variety of preservatives is available but some of them, like phenol, bisulfites, edetate and benzalkonium chloride can cause airway irritation and result in bronchoconstriction or reduce the efficacy of the medicine [57]. Other compounds such as chlorobutanol, methyl- and propyl-parahydroxybenzoate and also benzalkonium chloride are cUiotoxic at... 

Methyl parahydroxybenzoate and propyl parahydroxybenzoate may cause an itching sensation on the tongue in some people. 

In general methyl parahydroxybenzoate (sometimes combined with propyl parahydroxybenzoate) or sorbic acid are chosen. For stability reasons the pH is adjusted to 5 by the addition of potassium sorbate. If these substances caimot be used, the organic solvents mentioned earlier (ethanol or glycerine) are an alternative to a preparation less susceptible to microbial growth. 

Povidone (polyvidone, PVP) K 30 Povidone is used in the preparation of susptmsitms in order to facilitate resuspendability of the sedimoit on shaking. Complex formatitm between PVP and methyl parahydroxybenzoate or propyl parahydroxybenzoate is possible... 

Methyl hydroxybenzoate has an unfavourable partition coefficient. Therefore it is not a suitable preservative for o/w emulsions. It is mainly used in hydrogels. In some countries a combination with propyl hydroxybenzoate is used as Preserved water . A typical mixture contains 0.075 % of methyl parahydroxybenzoate and 0.025 % of propyl parahydroxybenzoate in purified water. 

Solubilisation may also be undesirable. Solutions containing polysorbate cannot be preserved with for example methyl or propyl parahydroxybenzoate. The preservative effect of these substances is inhibited by solubilisation or even nullified. With sorbic acid/sorbate, preservation is possible, provided that a higher than conventional concentration is used. 

Examples of substances that are prone to hydrolysis are acetylsalicylic acid, ampicillin, barbiturates, chloramphenicol, chlordiazepoxide, cocaine, corticosteroid phosphate or succinate esters, proteins, folinic acid, indomethacin, local anaesthetics, paracetamol (acetaminophen), pilocarpine, tropa alkaloids (atropine, scopolamine), xylomethazoline and the antimicrobial preservatives methyl and propyl parahydroxybenzoate. In the field of oncology, melphalan and bendamustine hydrochloride are highly susceptable to hydrolysis with a shelf life of 1.5 h for melphalan and 3.5 h for bendamustine at room temperature. 

Dissolve, whilst heating, the methyl parahydroxybenzoate and the propyl parahydroxybenzoate in the main part of the purified water. 

Propyl parahydroxybenzoate 0.3 mg/mL Antimicrobial activity at pH 4-8, decreasing with increasing pH [5] Allergic reactions... 

Propyl parahydroxybenzoate is more lipophilic than methyl parahydroxybenzoate and therefore less soluble in water (0.035-0.05 %), but the active concentration is also lower around 0.03 %. It is currently used with methyl parahydroxybenzoate, mostly because of the synergistic effect. Combinations methyl parahydroxybenzoate propyl parahydroxybenzoate 7 1, 7 3 or 3 1 give a better preservation than propyl parahydroxybenzoate alone. However, due to the poorer water solubility of propyl parahydroxybenzoate, those combinations will cause solubility problems rather than methyl parahydroxybenzoate alone. No data are known about its resistance to sterilisation. 

Propyl parasept 4-hydroxybenzoic acid propyl ester Propyl parahydroxybenzoate Propylparaben Nipasol M E 216 (sodium salt E 217). 

Trade Names Containing Bentone Gel LOIV Mackpro LOP Miracare PS Propyl parahydroxybenzoate Propyl parasept. See Propylparaben Propyl propasol. See Propylene glycol n-propyl ether 1-Propyne-3-ol Propyn-1-ol 1-Propyn-3-ol 2-Propynol 2-Propyn-1-ol 3-Propy-nol 2-Propynyl alcohol. See Propaigyl alcohol Prostearin. Propylene glycol stearate Protease... 

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