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Salicylic acid preparation

Salicylic acid USP, EP, and other pharmacopeia grades are used medically as antiseptic, disinfectant, antifungal, and keratolytic agents. Salicylic acid is formulated in lotion or ointment formulations for the treatment of dandruff, eczema, psoriasis, and various parasitic skin diseases. Because the keratolytic property of this aromatic acid has use in the safe removal of dead skin cells from the surface of healthy skin, the acid is used in concentrated salicylic acid solutions or suspensions to remove warts and corns. In more dilute form, salicylic acid preparations have found use in dandruff and eczema treatment. Salicylic acid has been considered and found effective by the Advisory Committees to the FDA in various over-the-counter (OTC) drug regulated uses. Among these are acne products, dermatitis, dry skin, dandruff and psoriasis products, and foot care products (24). [Pg.287]

Salicylism and death have occurred following topical application. In an adult, 1 g of a topically applied 6% salicylic acid preparation will raise the serum salicylate level not more than 0.5 mg/dL of plasma the threshold for toxicity is 30-50 mg/dL. Higher serum levels are possible in children, who are therefore at a greater risk for salicylism. In cases of severe intoxication, hemodialysis is the treatment of choice (see Chapter 58). It is advisable to limit both the total amount of salicylic acid applied and the frequency of application. Urticarial, anaphylactic, and erythema multiforme reactions may occur in patients who are allergic to salicylates. Topical use may be associated with local irritation, acute inflammation, and even ulceration with the use of high concentrations of salicylic acid. Particular care must be exercised when using the drug on the extremities of patients with diabetes or peripheral vascular disease. [Pg.1302]

Pseudomonadplasmid -salicylic acid preparation [SALICYLIC ACID AND RELATED COMPOUNDS] pol 21)... [Pg.823]

Salicylism and death have occurred following topical application. In an adult, 1 g of a topically applied 6% salicylic acid preparation will raise the serum salicylate level not more than 0.5 mg/dL of plasma the threshold for toxicity is 30-50 mg/dL. Higher serum levels are possible in children,... [Pg.1462]

Tape stripping can be further used to investigate intercorneocyte cohesion within the SC by quantifying the amount of SC removed.11 When using standardized tape stripping conditions, the more SC removed, the smaller the SC cohesion. For instance, tape stripping in combination with a protein assay to accurately quantify SC removal proved to be a sensitive method in detecting keratolytic efficacy of salicylic acid preparations within hours of application.27 This method may also be useful to measure the influence of moisturizers or other skin care preparations on SC cohesion. [Pg.462]

Salicylic acid (3) is a mild irritant and application of salicylic acid preparations to the skin may cause dermatitis. Symptoms of acute systemic salicylate poisoning have been reported after the application of asalicylic acid to large areas of the body. [Pg.447]

Firstly, you should check that she has been using the salicylic acid preparations properly and for long enough. Even if she has been using them properly, it would take up to about 3 months to get rid of the verruca. Her other options now are to do nothing, and the chances are that the verruca will go of its own accord within the next few months or have the verruca removed with cryotherapy, which should work immediately, although the area is likely to be quite sore for several days after treatment. [Pg.217]

Keratolytics are available in a multitude of formulations for treating skin diseases. Prolonged use of salicylic acid preparations over large areas, especially in children and patients with renal and hepatic impairment, can result in salicylism. Irritation is a common side effect with higher concentrations. Lactic acid (Lac-hydrin, others) is an emoUient that contains 12% lactic acid, which is an effective moisturizer indicated for the treatment of xerosis and ichthyosis vulgaris. [Pg.331]

C7H6O2 Oily liquid of aromatic odour b.p. 196°C. (t is prepared by the action of chloroform and caustic potash on phenol (the Reimer-Tiemann reaction) or by the oxidation of the glucoside salicin. It is easily reduced to salicyl alcohol or oxidized to salicylic acid. [Pg.350]

It should be emphasised that salicylic acid can be readily acetylated by Method 1, and that the above preparation of acetylsalicyclic acid is given solely as an illustration of Method 2. To employ Method 1, add 10 g. of salicylic acid to 20 ml. of a mixture of equal volumes of acetic anhydride and acetic acid, and boil gently under reflux for 30 minutes. Then pour into about 200 ml. of cold water in order to precipitate the acetylsalicylic acid (11 g.) and finally recrystallise as above. Method 2, however, gives the purer product. [Pg.111]

The methyl ester formed by substituting methanol for ethanol in the above reaction has an even stronger odour and should be prepared if salicylic acid is suspected. [Pg.348]

Salicylic acid. The preparation of salicylic acid by passing carbon dioxide into dry sodium phenoxide at 170-190° is the classical example of the Kolbe-Schmltt reaction. The latter is a method for introducing a carboxyl group directly into a phenol nucleus. [Pg.754]

The key compound m the synthesis of aspirin salicylic acid is prepared from phe nol by a process discovered m the nineteenth century by the German chemist Hermann Kolbe In the Kolbe synthesis also known as the Kolbe—Schmitt reaction, sodium phen oxide IS heated with carbon dioxide under pressure and the reaction mixture is subse quently acidified to yield salicylic acid... [Pg.1006]

Section 24 10 The Kolbe-Schmitt synthesis of salicylic acid is a vital step m the preparation of aspirin Phenols as their sodium salts undergo highly regioselective ortho carboxylation on treatment with carbon dioxide at elevated temperature and pressure... [Pg.1017]

Kolbe-Schmitt reaction (Section 24 10) The high pressure re action of the sodium salt of a phenol with carbon dioxide to give an o hydroxybenzoic acid The Kolbe-Schmitt reac tion IS used to prepare salicylic acid in the synthesis of as pinn... [Pg.1287]

Students determine the concentrations of caffeine, acetaminophen, acetylsalicylic acid, and salicylic acid in several analgesic preparations using both CZE (70 mM borate buffer solution, UV detection at 210 nm) and HPLC (C18 column with 3% v/v acetic acid mixed with methanol as a mobile phase, UV detection at 254 nm). [Pg.614]

Manufacture. Several methods have been described for the preparation of -hydroxyben2oic acid. The commercial technique is similar to that of salicylic acid, ie, Kolbe-Schmitt carboxylation of phenol. The modification includes the use of potassium hydroxide in place of caustic (51). The dried potassium phenate is heated under pressure, 270 kPa (2.7 atm) or more, with dry carbon dioxide at 180—250°C. The potassium salt [16782-08-4] of Nhydroxyben2oic acid forms almost quantitatively and can be converted to free acid by using a mineral acid. [Pg.292]

As of 1991 in the United States, OTC antiacne preparations may contain only a few active dmgs, for example, sulfur [7704-34-9] resorcinol acetate [102-29-4], resorcinol [108-46-3], salicylic acid [69-72-7], and some combinations (52). OTC anti-acne constituents maybe included in a variety of conventional cosmetic preparations, which then become OTC dmgs. These include lotions, creams, solutions, facial makeups, facial cleansers (including abrasive cleansers), and astringents. Products must contain the specified dmgs at the designated concentrations. Compositions of antiacne products have beenpubhshed (53). [Pg.297]

Salicyl-u-toluide has been prepared only by the action of phosphorus oxychloride upon a mixture of salicylic acid and o-toluidine. The useful methods of preparation of salicylanilide are by the interaction of salicylic acid and aniline in the presence of phosphorus trichloride, by heating phenyl salicylate and aniline, and from o-hydroxybenzamide and bromobenzene in the presence of small amounts of sodium acetate and metallic copper. A number of these and other anilides have been described. ... [Pg.94]

Salicylic acid, the starting material for the preparation of aspirin. [Pg.33]

The best known aryl ester is O-acetylsalicylic acid, better known as aspirin. It is prepared by acetylation of the phenolic hydroxyl group of salicylic acid ... [Pg.1006]

The popularity of aspirin has led to the preparation of a liost of relatively simple derivatives in the hope of finding a ilrug that would be either superior in action or better tolerated. i alicylamide (5), for example, is sometimes prescribed for pa-I Lents allergic to aspirin. It should be noted, however, that I his agent is not as active as the parent compound as an antiinflammatory or analgesic agent. This may be related to the fact I hat salicylamide does not undergo conversion to salicylic acid i 11 the body. [Pg.109]

Finally, attachment of a rather complex side chain to the para position of the benzene ring on the sulfonamide leads to the very potent, long-acting oral antidiabetic agent, glyburide (215). Preparation of this compound starts with the chlorosul-fonation of the acetamide of 3-phenethylamine (209). The resulting sulfonyl chloride (210) is then converted to the sulfonamide (211) and deacylated (212). Reaction with the salicylic acid derivative, 213, in the presence of carbodiimide affords the amide, 214. Condensation of that with cyclohexylisocyanate affords glyburide (215). ... [Pg.139]

A method of preparation is to react an acid salt of choline (such as choline chloride or choline bromide) with an alkaline salt of salicylic acid (such as sodium salicylate, potassium salicylate, or magnesium salicylate) in an alcoholic media. [Pg.334]

The 4-chloro-5-sulfamyl salicylic acid used as starting point was prepared in the following way ... [Pg.1595]

Conversion of Acid Anhydrides into Esters Acetic anhydride is often used to prepare acetate esters from alcohols. For example, aspirin (acetylsalicylic acid) is prepared commercially by the acetylation of o-hydroxybenzoic acid (salicylic acid) with acetic anhydride. [Pg.807]

Aspirin, C9H804, is prepared by reacting salicylic acid QHQ with acetic anhydride, C4He03> in die reaction... [Pg.71]

Perhaps the most widely known compound prepared from phenol is aspirin. If phenol, sodium hydroxide, and carbon dioxide are heated together under pressure, salicylic acid is formed (as the sodium salt) ... [Pg.346]

Salicylic acid solution. Prepare a 6 per cent solution of salicylic acid in acetone. [Pg.725]


See other pages where Salicylic acid preparation is mentioned: [Pg.823]    [Pg.187]    [Pg.285]    [Pg.823]    [Pg.187]    [Pg.285]    [Pg.261]    [Pg.314]    [Pg.398]    [Pg.457]    [Pg.618]    [Pg.469]    [Pg.283]    [Pg.295]    [Pg.53]    [Pg.108]    [Pg.280]    [Pg.501]    [Pg.1853]   
See also in sourсe #XX -- [ Pg.803 ]

See also in sourсe #XX -- [ Pg.803 ]




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