Salicylic acid ethyl ether

Ethyl Salicylate. 2 Hydroxybenzoic acid ethyl ester Salicylic acid ethyl ester salicylic ether sal ethyl. C,H. Oj mol wt 166.17. C 65.05%, H 6.07%, O 28.88%. HOC4H4COOCjH5. 

Beilstein Handbook Reference) AI3-00513 Benzoic acid, 2-hydroxy-, ethyl ester BRN 0907659 EINECS 204-265-5 o-(Ethoxycarbonyl)phenol Ethyl 2-hydroxybenzoate Ethyl o-hydroxybenzoate Ethyl salicylate PEMA No. 2458 Mesotol NSC 8209 Sal ether Sal ethyl Salicylic acid, ethyl ester Salicylic ether Salicylic ethyl ester Salotan. Used in perfumery has been used in veterinary medicine as a counter-irritant. Crystals mp = 45° bp = 231-234°, bpio = 150-151° d = 1,1326 Xm = 238, 305 nm (c = 13800, 6590, MeOH) insoluble in H2O, soluble in CCI4, very soluble in Et20, freely soluble in EtOH,... 

S g of ethyl glycinate hydrochloride were dissolved in 400 cc of ethanol and 33.5 g of salicylic aldehyde were added. It is refluxed for half an hour and cooled. 38 cc of triethylamlne and 25 g of Raney nickel are then added whereafter hydrogenation is carried out at room temperature and under atmospheric pressure. After hydrogen adsorption was complete, the mixture was filtered and the alcohol evaporated off. The residue was taken up with acidified water, extracted with ether to eliminate part of the by-products, consisting mainly of o-cresol, then made alkaline with ammonia and extracted with ethyl acetate. The solvent was removed in vacuo and the residue crystallized from ether/petroleum ether. 36.7 g of o-hydroxybenzyl-aminoacetlc acid ethyl ester melting at 47°C are obtained. 

Ethyl n-propylmalonate, 486 Ethyl n-propyl ketone, 340 4-Ethylpyridine, 844 Ethyl 2-pyridylacetate, 931, 932 Ethyl salicylate, 783 Ethyl sulphite, 304 Ethyl -valerate, 382, 389 Ethyl vinylacetate, 382, 389 Ethylenediamine-adipic acid polymer, 1019,1025 Ethylene glycol, 285 Ethylene glycol, monoalkyl ethers of, 170, 444... 

The crude material, which is a mixture of pimelic acid and unchanged salicylic acid, is esterified by boiling for four hours with 260 cc. of absolute ethyl alcohol and 3 cc. of concentrated sulfuric acid. Two-thirds of the alcohol is then removed by distillation. To the residue, 300 cc. of water and 200 cc. of ether are added, the mixture is shaken and the aqueous layer is removed. The ether solution is washed with two 100-cc. portions of 2 N sodium hydroxide solution to remove the ethyl salicylate (Note 7) and then with water until the disappearance of an alkaline reaction. The ether is evaporated and the residue is distilled under reduced pressure. The ethyl pimelate boils at i53-i56°/24 mm. i48-i52°/22 mm. The yield is 27-30 g. (35-38 per cent of the theoretical amount based upon the salicylic acid used). 

A mixture of 20 g. (0.1 mole) of o-bromobenzoic add, 63 cc. of 10% potassium hydroxide solution, 20 cc. of ethyl alcohol, 40 cc. of 50% tripotassium arsenite solution, and a little freshly reduced copper is refluxed at 90-95° for twelve hours with constant stirring. The reaction mixture is filtered hot to remove copper, made add to Congo red paper with 20 cc. of concentrated hydrochloric add, and evaporated to dryness on a steam cone. The resulting residue is extracted with absolute methanol the methanol extract is evaporated to dryness, and the residue is washed with ether to remove salicylic acid and unchanged o-bromo-... 

Esters.— The simplest class of compounds present in essential oils are the esters or ethereal salts (p. 140). In our early discussion of these compounds in the aliphatic series it was stated that the odor and flavor of common fruits is probably due to ester compounds and that certain empirical mixtures of esters are used as artificial fruit essences. Artificial apple essence, for example, may be prepared by mixing certain proportions of ethyl nitrite, ethyl acetate and amyl valerate with chloroform, aldehyde and alcohol. An example of an essential oil which consists of a single ester is oil of wintergreen. vAdxh is the methyl ester of salicylic acid, ortho-hydroxy benzoic acid (p. 714). 

Determination of salicylic acid in aspirin by second derivative U.V. spectrophotometry. The powdered aspirin was extracted with anhydrous ethyl ether, filtered extract was evaporated and the residue was dissolved in dioxan. This solution was analysed by second derivative spectrophotometry at 380 nm (27). 

Tang etah (54) have also reported HPLC determination of serum salicylic acid and aspirin concentrations. Serum (0.1 ml) was treated 1 fj of carbamazepine (internal standard) solution (0.65 mg/ml), 0.1 ml of 0.1 M-phosphate buffer of pH 7.4, 10 //I of 21.25% H3P04 and 1.2 ml of ethyl ether prior to centrifugation at 4000 rpm... 

Drugs are known that are only active because they are metabolized to bioactive chemical species. An intrinsically active drug is frequently converted to an active metabolite. Well-known examples are the hydrolysis of aspirin to salicylic acid by esterase enzymes, the cleavage of the ethyl ether group of phenacetin to acetaminophen, the demethylation of imipramine to desipramine, and the oxidation of phenylbutazone to oxyphenbutazone. In some cases the precursor drug and its metabolite are both used therapeutically. 

Figure 9.9. Left The corrected fluorescence excitation and emission spectra of acetylsaiicylic acid (ASA). / 1% acetic acid in chloroform, only the 278-nm excitation band can be observed in ethyl ether-isopentane-ethanol solvent, both the 235- and Yli-nm excitation bands are observed. Right The corrected fluorescence excitation and emission spectra of salicylic acid (SA) as obtained in 1% acetic acid in chloroform. From...

Ammonium alum Balsam Peru (Myroxylon pereirae) Sodium percarbonate antiseptic, mild pharmaceuticals Sodium salicylate antiseptic, mild sunscreen lotions Sodium salicylate antiseptic, mucosa Sodium iodate antiseptic, oral care Tea tree (Melaleuca altemifolia) oil antiseptic, oral pharmaceuticals Terpene resin antiseptic, oral rinses Eucalyptol Salicylic acid antiseptic, pharmaceutical ointments Tea tree (Melaleuca altemifolia) oil antiseptic, pharmaceutical topicals Didecyidimonium chloride antiseptic, pharmaceuticals Benzoic acid Bismuth subgallate Cetalkonium chloride Cetylpyridinium chloride Ethyl ether Eugenol Gum benzoin Peracetic acid Thymol 3,4,4 -Trichlorocarbanilide Urea... 

Butyl lactate Butyl laurate Butyl levulinate N-Butyl-2-methylbutyrate Butylparaben Butyl phenylacetate n-Butyl propionate Butyl salicylate Butyl stearate Butyl sulfide Butyl 10-undecenoate Butyl valerate n-Butyraldehyde n-Butyric acid Cadinene Camphene Caproic acid Caprylic alcohol Carvacrol Carvacryl ethyl ether Carveol 4-Carvomenthenol Carvone d-Carvone cis-Carvone oxide... 

Isobutyl 2-furanpropionate Isobutyl heptanoate Isobutyl hexanoate Isobutyl isobutyrate 2-lsobutyl-3-methoxy-pyrazine a-lsobutylphenethyl alcohol Isobutyl phenylacetate Isobutyl propionate Isobutyl salicylate 2-lsobutylthiazole Isobutyric acid Isoeugenol Isoeugenyl benzyl ether Isoeugenyl ethyl ether Isoeugenyl formate... 

The sample you are given may contain one of the following combinations of solid and liquids (the solid is listed first) fluorene, methylene chloride, water triphenylmethanol, diethyl ether, water salicylic acid, methylene chloride, 1 M NaOH ethyl 4-aminobenzoate, diethyl ether, 1 M HCl naphthalene, hexane, water benzoic acid, diethyl ether, 1 M NaOH p-aminoacetophenone, methylene chloride, 1M HCl. 

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