Bioactive chemicals

Andrographolide, a labdane-diterpenoid lactone, is the principal bioactive chemical constituent of Andrographis paniculata (Brum. F.) Nees (family Acanthaceae) this prime constituent is mainly concentrated in leaves and can easily be isolated from the crude plant extracts as crystalline... 

Total BioactIve Chemical Space of hERG Channel Blockers... 

From a chemical point of view, the half-life of fluorine-18 allows multi-step synthetic approaches that can be extended over hours. Fluorine-18 has therefore, in spite of its somewhat limited chemical repertoire, been effectively used for the labelling of numerous both relatively simple and complex bioactive chemical structures [3,5-9], including high-molecular-weight macromolecules such as peptides, proteins [10-13] and oligonucleotides [14-18]. General considerations on radiochemistry involving short-lived positron emitters will be discussed in Section 2.3. 

Behavioral and psychological symptoms of dementia (BPSD), 72 Benzodiazepine receptors, 76-77 Benzylamines, fluorine substituted, 666-668 Bioactive chemical structures, 6 Bioceramics... 

Bioactive chemicals such as pesticides, disinfectants, and pharmaceuticals must have certain reactivity within their range of application. They exert their reactivity within a special environment, such as within the human body, where they are activated in a specific manner. It should also be noted that some pharmaceuticals are applied as prodrugs. Before they can exert their desired effects, prodrugs are activated in the human body. Any effect, wanted or unwanted, is based on interaction of APIs with other molecules, for example, receptors or enzymes. They display their reactivity within a specific environment, such as within the human body, where they are activated in a specific manner. In summary, fully stable chemicals and pharmaceuticals would not be of any use in most cases, because they would not undergo any interaction or reaction with the environment, which is often required for their application. We normally speak of the stability of a chemical without mentioning the context of its environment. We assume that the stability of a chemical is an intrinsic... 

Most of these systems use test organisms—for example, bacteria—that lack suitable enzyme systems to bioactivate chemicals, and therefore an exogenous activating system is used. Usually the postmitochondrial fraction from rat liver, containing both phase I and phase II enzymes, is used as the activating system. The critical question is, To what... 

Nava-Rodriguez, V. Hemandez-Bautista, B.E., Cruz-Ortega, R., Anaya, A.L. Allelopathic potential of beans (.Phaseolus spp.), other crops, and weeds from Mexico. Allelopathy J Neori, A., Reddy, K.R., Ciskova-Koncalova, H., Agami, M. Bioactive chemicals and biological-biochemical activities and their functions in rhizospheres of wetland plants. Bot Rev 2000 66 350-378. 

Exploration of the molecular basis of human disease will continue to provide additional targets for drug discovery, while a better understanding of marine ecological interactions at the molecular level can be used to guide the selection of novel sources and novel screens. This multidisciplinary approach to discovery of marine-derived drugs will likely result in the continued discovery of unique bioactive chemical entities and new ways to address the treatment of human disease. 

LESSONS FROM NATURE CAN ECOLOGY PROVIDE NEW LEADS IN THE SEARCH FOR NOVEL BIOACTIVE CHEMICALS FROM TROPICAL RAINFORESTS ... 

ECOLOGY AS A KNOWLEDGE-BASED SOURCE OF LEADS IN THE SEARCH FOR NEW BIOACTIVE CHEMICALS... 

SEEDS OF DISCOVERY AN EXAMPLE OF APPLYING ECOLOGY TO MORE EFFECTIVELY TARGET SOURCES OF NEW BIOACTIVE CHEMICALS... 

Preliminary results from our studies support much of which we hypothesized and clearly show the power of using ecology to target the search for bioactive chemicals. For example, our studies of crude extracts from the large-seeded species show ... 

Symbiosis, mutually beneficial association between dissimilar organisms, is a powerful driving force in nature and a strategy used frequently to deal with resource limitations in complex and difficult environments. There are good reasons why we should learn from nature and look for opportunities for symbioses between ecologists and natural product chemists in the study of bioactive chemicals from tropical forests. Such interactions will result in ... 

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