Responsive delivery

The authors also demonstrated that low-frequency ultrasound acts as a transcutaneous immunization adjuvant that eliminates the requirement of toxins to elicit an immune response. Delivery of as little as 1.3 p.g of tetanus toxoid by low-frequency ultrasound generated an immune response comparable to that induced by 10 pg subcutaneous injection. 

Due to their highly biocompatible nature, dendritic PGs have a broad range of potential applications in medicine and pharmacology. The versatility of the polyglycerol scaffolds for application in the biomedical field has recently been reviewed [131], and a number of examples were described, therein, e.g., smart and stimuli-responsive delivery and release of bioactive molecules, enhanced solubilization of hydrophobic compounds, surface-modification and regenerative therapy, as well as transport of active agents across biological barriers (cell-membranes, tumor tissue, etc.). 

Poly(amino acid)s (PAAs) have also been used in drug delivery PEO-(l-aspartic acid) block copolymer nano-associates , formed by dialysis from a dimethyl acetamide solution against water, could be loaded with vasopressin. PLA-(L-lysine) block copolymer microcapsules loaded with fluorescently labelled (FITC) dextran showed release profiles dependent on amino acid content. In a nice study, poly(glutamate(OMe)-sarcosine) block copolymer particles were surface-grafted with poly(A-isopropyl acrylamide) (PNIPAAm) to produce a thermally responsive delivery system FITC-dextran release was faster below the lower critical solution temperature (LCST) than above it. PAAs are prepared by ring-opening polymerisation of A-carboxyanhydride amino acid derivatives, as shown in Scheme 1. 

Magnetic nanoparticles " or CdS nanoparticles have also been used to cap mesoporous silica to create a stimuH responsive delivery system. Coating the mesoporous particles with polyelectrolytes or polyelectrolyte multilayers has been used to create stimuh responsive drug release via Particles have been also been coated with... 

Douglass, P.M., S. Daunert, J.D. Patel, L.G. Bachas, K.-Q. He, and M.J. Madou. 2000. Biologically inspired, intelligent muscle material for sensing and responsive delivery of countermeasures. Soc... 

The direct synthesis of functional, self-assembling copolymers in aqueous media under mild conditions without protection/deprotection chemistry steps, however, remains a current challenge that focuses research efforts on developing stimuli-responsive delivery systems such as micelles... 

P-CD Alkyl triphenyl phosphonium bromide Hydrogels Responsive delivery [64]... 

HP-y-CD Poloxamer, sodium alginate, HPMC Hydrogels Baicalein Improved stability and mucosa responsive delivery [63]... 

Unlike events managanent, natural disasters do not keep to a timetable. None the less as a disaster will require quick response delivery of materials and services, an efficient supply chain would scan to be important. From a study of the literature and media reports it is found that the general perception is that money is not spent wisely, and overall performance of relief agencies be they government funded or private are generally not as efficient as they conld be or should be. 

Intelligent stimuli-responsive delivery systems using hydrogels that can release insulin are referred to as glucose-sensitive hydrogels and are a field of intensive research (Ehrick et al, 2009 Kim and Park, 2001 Traitel et al, 2000). One of the challenges in the controlled drug delivery area includes the... 

DoUendorf, C., Hetzer, M., Ritter, H. Polymeric redox-responsive delivery systems bearing ammonium salts cross-linked via disulfides. Beilstein J. Org. Chem. 9, 1652-1662 (2013)... 

Electronically-responsive delivery from a calcified mesoporous silicon structure. Biomedical Microdevices, 8, 93-7. 

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