Responsive delivery systems

G heparin-binding growth factor M attached cleavable peptide bound heparin [Pg.275]

Polymeric membranes can be used to control the rate of release. Reservoir and transdermal devices are conceptually simple the rate of drug release can be predicted by simple mathematical expressions. However, many drugs are not suitable for use in membrane-type devices. [Pg.275]

Matrix-type delivery systems are simple to make release is usually controlled by diffusion of drug through the polymer matrix. Mathematical descriptions of release are more complicated than are obtained for membrane-type devices, and it is difficult to produce devices that provide a constant rate of release. However, these materials are versatile and almost any compound can be formulated into a controlled-release matrix. [Pg.276]

Degradable polymers, particularly polymers that degrade by hydrolysis, are appealing materials for use in clinical medicine because they disappear after implantation. Degradation is often difficult to control families of related polymers provide the greatest versatility in design. [Pg.276]

Folkman, J. and D. Long, The use of silicone rubber as a carrier for prolonged drug therapy. Journal of Surgical Research, 1964, 4, 139-142. [Pg.276]

Poly(amino acid)s (PAAs) have also been used in drug delivery PEO-(l-aspartic acid) block copolymer nano-associates , formed by dialysis from a dimethyl acetamide solution against water, could be loaded with vasopressin. PLA-(L-lysine) block copolymer microcapsules loaded with fluorescently labelled (FITC) dextran showed release profiles dependent on amino acid content. In a nice study, poly(glutamate(OMe)-sarcosine) block copolymer particles were surface-grafted with poly(A-isopropyl acrylamide) (PNIPAAm) to produce a thermally responsive delivery system FITC-dextran release was faster below the lower critical solution temperature (LCST) than above it. PAAs are prepared by ring-opening polymerisation of A-carboxyanhydride amino acid derivatives, as shown in Scheme 1. [Pg.101]

Magnetic nanoparticles " or CdS nanoparticles have also been used to cap mesoporous silica to create a stimuH responsive delivery system. Coating the mesoporous particles with polyelectrolytes or polyelectrolyte multilayers has been used to create stimuh responsive drug release via Particles have been also been coated with... [Pg.126]

The direct synthesis of functional, self-assembling copolymers in aqueous media under mild conditions without protection/deprotection chemistry steps, however, remains a current challenge that focuses research efforts on developing stimuli-responsive delivery systems such as micelles... [Pg.589]

Intelligent stimuli-responsive delivery systems using hydrogels that can release insulin are referred to as glucose-sensitive hydrogels and are a field of intensive research (Ehrick et al, 2009 Kim and Park, 2001 Traitel et al, 2000). One of the challenges in the controlled drug delivery area includes the... [Pg.251]

DoUendorf, C., Hetzer, M., Ritter, H. Polymeric redox-responsive delivery systems bearing ammonium salts cross-linked via disulfides. Beilstein J. Org. Chem. 9, 1652-1662 (2013)... [Pg.369]

Lee SM, Chen H, Dettmer CM, O Halloran TV, Nguyen ST (2007) Polymer-caged lipsomes A pH-responsive delivery system with high stability. J Am Chem Soc 129 15096-15097 Venturoli M, Smit B, Sperotto MM (2005) Simulation studies of protein-induced bilayer deformations, and lipid-induced protein tilting, on a mesoscopic model for lipid bilayers with embedded proteins. Biophys J 88 1778-1798... [Pg.81]

Bayer CL, Peppas NA. Advances in recognitive, conductive and responsive delivery systems. J Control Release. 2008 132 216-221. [Pg.247]

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