Poly-D-glutamate

Fe (quaterpy)(OH)2] anchored to poly-L-glutamate or to poly-D-glutamate acts as a catalyst for the oxidation of epinephrine by H202. [Fe(quaterpy)X2] interacts with bio-substrates. [(H20)(quaterpy)Fe —O—Fe (quaterpy)(H20)] + has been prepared as the dihydrate of its perchlorate salt. " ... 

Selective oxidations of optically active substrates by iron(II) complexes were observed in the oxidation of L-dopa and L-adrenaline by [Fe(tetpy)(OH)2]+ complex ions (14) anchored to poly(L-glutamate) (FeTL) or poly(D-glutamate) (FeTD)74). 

Fig. 3 CD spectra of a solution of CuT4 (4 pM) in the presence of poly-glutamate (200 pM) (a) l-and (b) D-, after addition of H2TPPS (4 pM). Inset CD spectra of a solution of CuT4 (4 pM) in the presence (a) of poly-L-glutamate (200 pM) at pH 3.6 and (b) the same solution after the addition of fourfold excess of poly-D-glutamate. Modified from [37]...

However, these supramolecular ternary complexes behave quite differently compared to the parent binary species. In fact, the addition of a fourfold excess of poly-L-glutamate to ternary complexes built on the poly-D-glutamate does not lead to the inversion of the induced CD signal in the Soret region (even after 5 days following the addition). The only indication of the L-form excess is the inversion of the helix marker bands at 222 nm and 208 nm (Fig. 4). The same behaviour has been observed for the ternary L -supramolecular species upon addition of an excess of... 

H2TPPS + ZnT4, or MnT4, or AuT4 Poly-L-glutamate or poly-D-glutamate (not removable) pH 2.9 Dynamic (induction, pH reversible)... 

Contains poly-D-glutamic acid capsule, essential for virulence and avoidance of immune detection... 

KIshore BK, Lambricht P, Laurent G, Maldague P, Wagner R,Tulkens PM, Mechanism of protection afforded by polyaspartic acid against gentamicin-Induced phosphollpidosis. II. Comparative In-vltroand In-vivo studies with poly-L-aspartIc, poly-L-glutamIc and poly-D-glutamIc acids, J Pharmacol ExpTherap, 1990,255(2) 875-85. 

Poly( a-amino acid/vis a better term for peptides formed by the self-condensation of one amino acid natural examples exist, such as poly(D-glutamic acid), the protein coat of the anthrax spore (Flanby and Rydon, 1946). In early research in the textile industry, poly(a-amino acid)s showed promise as synthetic fibres, but the synthesis methodology required for the polymerisation of amino acids was complex and uneconomic. 

A special case of stepwise amino acid addition is repeated condensation to arrive at polymer structures. Such systems functioning in analogy to. for example, polyhydroxybu-tyrate-forming enzymes produce, for example, poly-D-glutamic acids (40,41), and they presumably are related to the polyenzyme type of peptide synthetases. These enzymes, condensing 3-carboxyl-groups, produce a size-defined polymer of about 10 Da. Other systems may produce poly-Lys chains of much smaller size, 25 residues (42). Even branched peptide-forming systems have been reported (43). None of these systems has been characterized in detail. 

The conformation of stendomycin was studied by circular dichroism. In trifluoroethanol the circular dichroism pattern was almost identical with that of left-handed a-helical poly-D-glutamic acid in water at pH 3.9 the amplitude was half that of poly-D-glutamic acid. The presence of a-helical zones in stendomycin was supported by the occurrence... 

Poly(D-glutamic acid) y-benzyl-chloro-meta (253.68) ortho para... 

Poly(D-glutamic acid), sodium salt 30811-79-1 D-Glutamic acid, homopolymer, sodium salt R (C,H9N04),- jtNa... 

Fig. 5. The helix-coil transition of poly(D-glutamic acid) as revealed by conductance-transference. Solid lines are the limiting laws for/, Equation (102), for the helical structure = 4.75 a, and the coil structure, < = 1.98 a, a being the degree of neutralization. Conductance-transference data (open...

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