Drug responses

Drug Response as Seen Through the Cellular Veil ... 

Certain factors may influence drug response and are considered when the primary health care provider prescribes and the nurse administers a drug. These factors include age, weight, gender, disease, and route of administration. 

TABLE 1-3 Factors Altering Drug Response in the Elderly... 

The presence of disease may influence the action of some dragp. Sometimes disease is an indication for not prescribing a drug or for reducing the dose of a certain drug. Bo Hi hepatic (liver) and renal (kidney) disease can greatly affect drug response... 

Q Ineffective Tissue Perfusion Peripheral related to adverse drug response (hypotension)... 

There is an increased risk for bone marrow suppression when levamisole or hydroxyurea are administered witii other antineoplastic dni. Use of levamisole witii phenytoin increases die risk of phenytoin toxicity. Pegaspargase may alter drug response of the anticoagulants. When procarbazine is administered with other central nervous system (CNS) depressants, such as alcohol, antidepressants, antihistamines, opiates, or the sedatives, an additive CNS effect may be seen. Procarbazine may potentiate hypoglycemia when administered witii insulin or oral antidiabetic dru . ... 

Evans WE, Johnson JA Pharmacogenomics the inherited basis for interindividual differences in drug response. Anna Rev Genomics Hum Genet 2001 2 9. 

Munthe, E., Kass, E. and Jellum, E. (1982). Evidence for enhanced radical scavenging prior to drug response in rheumatoid arthritis. In Advances in Inflammation Research (ed. S. Gorini) pp. 2II-2I8. Raven Press, New York. 

Murphy, H. B. (1969). Ethnic variations in drug response results of an international survey. Transcultural Psychiatric Res., 6, 5-23. 

Non-biologic factors that affect drug response... 

We have thus far focused on the biological factors that affect drug responses but recovery from illness often takes place in the context of interactions among individuals. In these interactions, both patient and clinician bring their own knowledge, predispositions, values, priorities, modes of thinking, and belief systems into play. Within this transaction, issues such as patient compliance, expectation effect ... 

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