Poly lactic-co glycolic acid

G. W., Poly(lactic-co-glycolic) acid mance in controlled release delivery systems of LHRH analogues, Proc. Int. Symp. Control. Rel. Bioact. Mater., 12, 177, 1985. Hutchinson, F. G., U.S. Patent 4,767,628, 1988. 

Beck, L. R., and Tice, T. R., Poly (lactic acid) and poly(lactic-co-glycolic acid) contraceptive delivery system, in Long Acting Steroidal Contraception (D. R. Mishell, ed.). Raven Press, New York, 1983, pp. 175-199. 

Jiang W, Gupta RK, Deshpande MC et al (2005) Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv Drug Deliv Rev 57 391 —410... 

Incorporation of F-chain end-groups into biodegradable polymers can help modulate their biodegradation (e.g., the hydrolysis rate of polyesters) and drug release [68], Surface treatment of polymer for example, poly(lactic-co-glycolic acid)... 

Fu, K., Pack, D.W., Klibanov, A.M., and Langer, R. (2000). Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharmaceut. Res., 17, 100-106. 

Early development of polymers in injectable drug delivery primarily involved PLA and poly(lactic-co-glycolic) acid (PLGA) due to the prior use of these polymers in biomedical applications as sutures. Besides the safe and biocompatible nature of these polymers, their ease of availability made them ideal first candidates for screening parenteral CR formulations. Some of the early biodegradable polymer-based products for injectable sustained release used these polymers. However because... 

Figure 3 Chemical structure of poly(lactic-co-glycolic) acid polymer. The x component represents lactic acid and y component represents glycolic acid. For other poly(hydroxy acids), the side-chain methyl group is replaced by other alkyl groups.

Table 4 A Partial List of Marketed Drug Delivery Products Utilizing Polylactic Acid or Poly(lactic-co-glycolic) Acid Polymers...

Abbreviations PLA, polylactic acid PLGA, poly(lactic-co-glycolic) acid. 

When the core is an oily liquid, the surrounding polymer is a single layer of polymer, and the vesicle is referred to as a nanocapsule. These systems have found utility in the encapsulation and delivery of hydrophobic drugs Polymers used for the formation of nanocapsules have typically included polyester homopolymers such as poly(D,L-lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA) and poly(caprolactone) PCL [112],... 

Polyesters, such as poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA), are examples of biomaterials that are degraded by homogeneous bulk erosion. 

Lu, W., and Park,T. G. (1995), Protein release from poly(lactic-co-glycolic acid) microspheres Protein stability problems, PDA J. Pharm. Sci. Technol., 49,13-19. 

Lam, X. M., Duenas, E. T., and Cleland, J. L. (2001), Encapsulation and stabilization of nerve growth factor into poly(lactic-co-glycolic) acid microspheres, J. Pharm. Sci., 90, 1356-1365. 

Li, J. K., Wang, N., and Wu, X. S. (1997), A novel biodegradable system based on gelatin nanoparticles and poly (lactic-co-glycolic acid) microspheres for protein and peptide drug delivery, J. Pharm. Sci., 86(8), 891-895. 

Poly(lactic-co-glycolic acid (PLGA) microparticles HBsAg Strong systemic and mucosal immune responses 226... 

Acrylic acid and derivatives have been free radically grafted onto the backbone of biodegradable polycaprolactone and poly(lactic-co-glycolic acid). These functionalized biocompatible materials are useful as drug delivery agents. 

Preparation of Poly[(Lactic-co-Glycolic Acid)-g-Acrylic Acid]... 

To prepare the graft copolymer, poly [(lactic-co-glycolic acid) (5.7 g) was dissolved in acrylic acid (5.7 g) and, upon dissolution, treated with 98% 2,2 -azobisisobutyronitrile (0.014 g). The mixture was then heated to 70°C and continued heating until the reaction mixture solidified. The solid was then placed into a vacuum oven to remove unreacted acrylic acid, and the product was isolated. 

TABLE 1. Biodegradable poly[(lactic-co-glycolic acid) substrates free radically functionalized with grafted acrylic acid or 2-hydroxylethyl acrylate. 

Crotts, G. Park, T.G. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres release kinetics and stability issues. J. of Microencap. 1998,15 (6), 699-713. 

Marchal-Heussler, L. Fessi, H. Devissaguet, J.P. Hoffman, M. Maincent, P. Colloidal drug delivery systems for the eye. A comparison of the efficacy of three different polymers polyisobutylcyanoacrylate, poly (lactic-co-glycolic Acid, poly-epsilon caprolactone. S.T.P. Pharma 1992, 2, 98-104. 

Spray desolvation involves spraying a polymer solution onto a desolvating liquid. For example, microparticles can be made by spraying a PVA solution onto an acetone bath. Here, the polymer solvent (water) is extracted into acetone, and PVA precipitates to form solid micro-particles.f In another example, bovine serum albumin (BSA) was encapsulated in poly(lactic-co-glycolic acid) (PLGA) by this method. The micronized drug was suspended in a PLGA-acetone solution and atomized ultrasonically into ethanol bath. ° ... 

Kempen Diederik, H.R. Lu, L. Zhu, X. Kim, C. Jabbari, E. Dhert Wouter, J.A. Currier Bradford, L. Yaszemski Michael, J. Development of biodegradable poly(propylene fumarate)/poly(lactic-co-glycolic acid) blend microspheres. II. Controlled drug release and microsphere degradation. J. Biomed. Mater. Res. 2004, 70A (2), 293-302. 

Wang, N. Wu, X.S. Li, J.K. A heterogeneously structured composite based on poly(lactic-co-glycolic acid) micro-spheres and poly(vinyl alcohol) hydrogel nanoparticles for long-term protein drug dehvery. Pharm. Res. 1999, 16 (9), 1430-1435. 

BSA = bovine serum albumin PLA = polylactic acid PLGA = poly(lactic-co-glycolic acid) PEG = poly(ethylene glycol) PPG = poly(propylen Extraction temperature/pressure. 

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