Poly lactic-co-glycolic acid PLGA

Fu, K., Pack, D.W., Klibanov, A.M., and Langer, R. (2000). Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharmaceut. Res., 17, 100-106. 

Early development of polymers in injectable drug delivery primarily involved PLA and poly(lactic-co-glycolic) acid (PLGA) due to the prior use of these polymers in biomedical applications as sutures. Besides the safe and biocompatible nature of these polymers, their ease of availability made them ideal first candidates for screening parenteral CR formulations. Some of the early biodegradable polymer-based products for injectable sustained release used these polymers. However because... 

When the core is an oily liquid, the surrounding polymer is a single layer of polymer, and the vesicle is referred to as a nanocapsule. These systems have found utility in the encapsulation and delivery of hydrophobic drugs Polymers used for the formation of nanocapsules have typically included polyester homopolymers such as poly(D,L-lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA) and poly(caprolactone) PCL [112],... 

Polyesters, such as poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA), are examples of biomaterials that are degraded by homogeneous bulk erosion. 

Poly(lactic-co-glycolic acid (PLGA) microparticles HBsAg Strong systemic and mucosal immune responses 226... 

Spray desolvation involves spraying a polymer solution onto a desolvating liquid. For example, microparticles can be made by spraying a PVA solution onto an acetone bath. Here, the polymer solvent (water) is extracted into acetone, and PVA precipitates to form solid micro-particles.f In another example, bovine serum albumin (BSA) was encapsulated in poly(lactic-co-glycolic acid) (PLGA) by this method. The micronized drug was suspended in a PLGA-acetone solution and atomized ultrasonically into ethanol bath. ° ... 

Cleland JL, Mac A, Boyd B, Yang J, Duenas ET, Yeung D, Brooks D, Hsu C, Chu H, Mukku V, Jones AJ. The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm Res 1997 14 420-425. 

Intimate mixture under pressure of the polymer material with a core material before or after SCF solvation of the polymer, followed by an abrupt release of pressure, leads to an efficient solidification of the polymeric material around the core material. This technique was used to microencapsulate infectious bursal disease virus vaccine in a polycaprolactone (PCL) or a poly(lactic-co-glycolic acid) (PLGA) matrix " ]. 

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