Microspheres biodegradable

FIGURE 9 Serum melatonin levels in goats treated with a single injection of biodegradable microspheres containing melatonin. 

Cha, Y., and Pitt, C. C., A one-week subdermal delivery system for L-methadone based in biodegradable microspheres,... 

J. L. Cleland and A. J. Jones, Stable formulations of recombinant human growth hormone and interferon-y for microencapsulation in biodegradable microspheres, Phar. Res, 13(10), 1464 (1996). 

P Stjarnkvist, I Sjoholm, T Laasko. Biodegradable microspheres. XII. Properties of the crosslinking chains in polyacryl starch microparticles. J Pharm Sci 78 52-56, 1989. 

Fig. 8 Preparation of biodegradable microspheres entrapping proteins using amphiphilic PDP-b-PLA block copolymers as biodegradable polymeric surfactants, and SEM images of their cross-sections. Reprinted from [182] with permission...

There are relatively few entries in the non-fused dioxepin area, and most of these focus on reactions of these systems. For example the triflic acid-initiated polymerisation of 1,3-dioxepane in the presence of acetic acid and hexanedicarboxylic acid has been studied and mechanistic aspects discussed <00JPS(A)1232>. Biodegradable microspheres for the controlled delivery of drugs have been made from copolymers and homopolymer blends of L-lactide and l,5-dioxepan-2-one <00PP1628>. Ring contraction of 5-methylene-l,3-dioxepanes (eg. Ill) on reaction with trimethylsilyl trifluoromethanesulfonate in the presence of base afforded the exo tetrahydropyrans, in good yields <00TL2171>. 

Eldridge, J.H. et al., Biodegradable Microspheres as a Vaccine Delivery System, Molecular Immunology. 28, 287, 1991. 

Arthursson P, Edman P, Sjoholm I (1985) Biodegradable microspheres II immune response to a heterologous and an autologous protein entrapped in polyacryl starch microparticles. J Pharmacol Exp Ther 255-260. 

Microcarrier particles Can encapsulate antigen and be carried across the mucosal epithelium Biodegradable microspheres, liposomes, vims-hke particles, stimulating complexes (ISCOMM... 

Laakso, T., Stjarnkvist, R, Sjoholm, 1. (1987). Biodegradable microspheres VI Lysosomal release of covalently bound antiparasitic drugs from starch microparticles. J. Pharm. Sci., 76( ), 134-140. 

Batycky, R.P, Hanes, J., Langer, R., and Edwards, D. A. (1997). A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J. Pharmaceut. Set, 86, 1464-1477. 

Eldridge, J.H., Hammond, C.J., Meulbroek, J.H., Staas, J.K., Gilley, R.M., and Tice, T.R. (1990). Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administrated biodegradable microspheres target the Peyer s patches. J. Control. Release, 11, 205-214. 

Arshady, R. Preparation of biodegradable microspheres and microcapsules 2. Polylactides and related polyesters. J. Contr. Rel. 17 1—22, 1991. 

Okada, H., and Toguchi, H. Biodegradable microspheres in drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 12(1) 1—99, 1995. 

DeLuca, P, Kanke, M., and Sayo, T. Biodegradable microspheres for injection and inhalation, in Microspheres and Drug Therapy Pharmaceutical, Immunological and Medical Aspects, ed. S. Davies et al. New York Elsevier Science Publishers, 1984, pp. 217-227. 

Tabata, Y., Inoue, Y., and Ikada, Y. Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres. Vaccine 14 1677-1685, 1996. 

Somatropin injectable suspension (Nutropin Depot) is a long-acting preparation of rhGH enclosed within biodegradable microspheres. These microspheres degrade slowly after subcutaneous injection such that the rhGH is released over about 1 month. 

The preparation of biodegradable microspheres by a solvent evaporation process using sodium oleate as the emulsifier was described in previous publications (1.21. A number of process parameters (such as drug loading, polymer molecular weight, polymer composition and initial polymer solution concentration) were studied to determine their effects on the release of drugs from biodegradable microspheres. 

Moritera, T.-O., Y., Yoshimura, N., Kuriyama, S., Honda, Y., Tabata, Y. and Ikada, Y. (1994) Feasibility of drug targeting to the retinal pigment epithelium with biodegradable microspheres. Current Eye Research, 13 171-176. 

Peptide/Protein Encapsulated into Biodegradable Microspheres Case Study... 

TABLE 2 Injectable Peptide/ProteinsTVacdnes Encapsulated in Biodegradable Microspheres... 

PEPTIDE/PROTEIN ENCAPSULATED INTO BIODEGRADABLE MICROSPHERES 419... 

Prabhu, S., Sullivan, J. L., and Betageri, G. V. (2002), Comparative assessment of in vitro release kinetics of calcitonin polypeptide from biodegradable microspheres, Drug Deliv., 9,195-198. 

Cleland, J. L. (1998), Solvent evaporation processes for the production of controlled release biodegradable microsphere formulations for therapeutics and vaccines, Bio-technol. Prog., 14,102-107. 

Costantino, H. R., Johnson, O. L., and Zale, S. F. (2004), Relationship between encapsulated drug particle size and initial release of recombinant human growth hormone from biodegradable microspheres,/. Pharm. Sci., 93, 2624-2634. 

Brunner, A., Mader, K., and Gopferich, A. (1999), pH and osmotic pressure inside biodegradable microspheres during erosion, Pharm. Res., 16,847-853. 

Hunter, S. K., andracki, M. E., and Kreig, A. M. (2001), Biodegradable microspheres containing group B Streptococcus vaccine Immune response in mice, Am. J. Obstet. Gynecol., 185,1174-1179. 

Peyre, M., Sesardic, D., Merkle, H. P., Gander, B., and Johansen, P. (2003), An experimental divalent vaccine based on biodegradable microspheres induces protective immunity against tetanus and diphtheria, J. Pharm. Sci., 92, 957-966. 

Genta, I., Perugini, P., Pavanetto, F., Maculotti, K., Modena, T., Casado, B., Lupi, A., Iadarola, R, and Conti, B. (2001), Enzyme loaded biodegradable microspheres in vitro ex vivo evaluation, J. Controlled Release, 77,287-295. 

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