Hydrogel nanoparticles

Akiyoshi K, Kobayashi S, Shichibe S et al (1998) Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs Complexation and stabilization of insulin. J Control Release 54 313-320... 

Na K, Park KH, Kim SW et al (2000) Self-assembled hydrogel nanoparticles from curdlan derivatives characterization, anti-cancer drug release and interaction with a hepatoma cell line (HepG2). J Control Release 69 225-236... 

Nanogels are nanometer-sized hydrogel nanoparticles (less than about 100 nm) with three-dimensional networks of physically crosslinked polymer chains. They have attracted growing interest over the last decade because of their potential for applications in biomedical fields, such as DDS and bioimaging [246-249]. 

Gao D, Xu H, Philbert MA, Kopelman R (2007) Ultrafine hydrogel nanoparticles synthetic approach and therapeutic application in living cells. Angew Chem Int Ed 46 2224—2227... 

Na, K., and Bae, Y. H. (2002),Self-assembled hydrogel nanoparticles responsive to tumor extracellular pH from pullulan derivative/sulfonamide conjugate Characterization, aggregation, and adriamycin release in vitro, Pharm. Res., 19(5), 681-688. 

Na, K., Lee, K. H., and Bae, Y. H. (2004), pH-sensitivity and pH-dependent interior structural change of self-assembled hydrogel nanoparticles of pullulan acetate/oligo-sulfonamide conjugate,/. Controlled Release, 97(3), 513-525. 

Missirks D, Tirelli N, Hubbell JA (2005) Amphiphilic hydrogel nanoparticles. Preparation, characterization, and preliminary assessment as new colloidal drug carriers. Langmuir 21 2605—2613. 

Wang, N. Wu, X.S. Li, J.K. A heterogeneously structured composite based on poly(lactic-co-glycolic acid) micro-spheres and poly(vinyl alcohol) hydrogel nanoparticles for long-term protein drug dehvery. Pharm. Res. 1999, 16 (9), 1430-1435. 

Jana SS et al (2002) Targeted cytosolic delivery of hydrogel nanoparticles into HepG2 cells through engineered Sendai viral envelopes. FEES Lett 515 184-188... 

Fig. 3 Formation of the core-shell type hydrogel nanoparticles by electrostatic interactions. The anionic solution which contains core polymer is introduced as a mist into a cationic solution of shell polymer. (Modified from Ref. l)...

Fig. 4 Self-assembled hydrogel nanoparticles of hydrophobically modified polysaccharides. Note that nanoparticles have multiple inner cores which physically cross-link the hydrophilic polysaccharide chain. (Modified from Ref...

Gan, D. Lyon, L.A. Tunable swelling kinetics in core-shell hydrogel nanoparticles. J. Am. Chem. Soc. 2001, 123, 7511-7517. 

Akiyoshi, K. Deguchi, S. Tajima, H. Nishikawa, T. Sunamoto, J. Microscopic structure and thermoresponsiveness of a hydrogel nanoparticle by self-assembly of a hydrophobized polysaccharide. Macromolecules 1997, 30, 857-861. 

Kim, I.S. Jeong, Y.I. Kim, S.H. Self-assembled hydrogel nanoparticles composed of dextran and poly(ethylene glycol) macromer. Int. J. Pharm. 2000, 205, 109-116. 

Akiyoshi K., Nishikawa T., Kobayashi S.-I., Sunamoto J. Self-assembled hydrogel nanoparticles complexation and stabilization of soluble proteins. In Yalpani M., ed. Biomedical Function and Biotechnology of Natural and Artificial Polymers. ATL Press 1996 115-125. 

Akiyoshi K., Sasaki Y., Sunamoto J. Molecular chaperone-like activity of hydrogel nanoparticles of hydrophobized pullulan thermal stabilization with refolding of carbonic anhydrase B. Bioconjugates Chem. 1999 10(3) 321— 324. 

Cellulose fibers that are partially hydrophobized by alkyl chains as well as cellulose itself align on water surfaces to form two-dimensional crystals, which are quite regular, in the direction of the polymer chain. In case of alkylated cellulose ( hairy rods ) multilayer grids of molecular size can be synkinesized if the direction of the LB plate is changed by 90° in each application (Fig. 4.6.4). Similar hydrophobized polysaccharides have also been used as hydrogel nanoparticles to bind albumin protein in water (Nishikawa et al., 1996)... 

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