Pentosan polysulfate

Pentosan polysulfate Inhibits heparin-binding growth factors... [Pg.85]

Among other polyions Meyerhoff s group demonstrated successful detection of pentosan polysulfate (PPS) [45], an anti-osteoarthritis drug, in plasma and polyanions with high phosphate content, including polyphosphates and nucleic acids in saline solutions [46],... [Pg.112]

N. Durust and M.E. Meyerhoff, Determination of pentosan polysulfate and its binding to polycationic species using polyion-sensitive membrane electrodes. Arm Chim. Acta 432, 253-260 (2001). [Pg.134]

Specihc poly anions such as dextran sulfate (DS) appear to exhibit strong anti-HIV activity in vitro [36,37]. Human oral administration of DS is poorly absorbed, but intravaneous administration does result in increased plasma lipolytic activity [38]. Poly anions that have been considered for intravaginal anti-HIV activity include DS, carrageenan, heparin, heparan sulfate, dermatan sulfate, pentosan polysulfate, fucoidan chondroitin sulfate, keratan sulfate, and PAVAS [21,22,39,40],... [Pg.225]

Fig. 3 Structures of acharan sulfate, dextran sulfate, suramin, pentosan polysulfate, and phosphomannopentaose sulfate (PI-88). Representative saccharide units comprising each of these polymers are shown, where n is the degree of polymerization.

Pentosan polysulfate (1 —> 4)-/3-linked xylan oligosaccharide that is branched in the center with a single /3-(l — 2)-4-O-methyl-ct-D-glucuronate residue... [Pg.286]

Recently, several new GAGs have been investigated as chiral selectors Dermatan sulfate has been successfully demonstrated to act as an enantiomeric selector for a variety of basic drugs, such as /3-sympatho-mimetics, /3-blockers, and antihypertensives (82). More recently, pentosan polysulfate was also investigated as a chiral selector for tryptophan derivatives and several drugs (83). [Pg.296]

SM Swain, B Parker, A Wellstein, ME Lippman, C Steakley, R Delap. Phase I trial of pentosan polysulfate. Invest New Drugs 13 55—62, 1995. [Pg.309]

M Degenhardt, P Ghosh, H Watzig. Studies on the structural variation of pentosan polysulfate sodium (NaPPS) from different sources by capillary electrophoresis. Archiv der Pharmazie 334 27-29, 2001. [Pg.309]

MG Waters, JF Suleskey, LJ Finkelstein, ME Van Overbeke, VJ Zizza, M Stommel. Interstitial cystitis a retrospective analysis of treatment with pentosan polysulfate and follow-up patient survey. J Am Osteo Assoc 100 S13-S18, 2000. [Pg.309]

X Wang, JT Lee, DW Armstrong. Separation of enantiomers by capillary electrophoresis using pentosan polysulfate. Electrophoresis 20 162-170, 1999. [Pg.312]

Pentosan Polysulfate Sodium (Elmiron) [Urinary Analgesic]... [Pg.253]

Contraindications Hypersensitivity to pentosan polysulfate sodium or structurally related compounds... [Pg.959]

Hyoscyamine, Atropine, Scopolamine, Phenobarbital (Donnatal, Others) Methenamine (Hiprex, Urex, others) Nitrofurantoin (Macrodantin, Furadantin, Macrobid) Oxybutynin (Ditropan, Ditropan XL) Oxybutynin Transdermal System (Oxytrol) Pentosan Polysulfate (Elmiron) Phenazopyridine (Pyridium, others) Potassium Citrate (Urocit-K)... [Pg.56]

HIV infection in humans is now pandemic. As of January 2006, the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization (WHO) estimate that AIDS has killed more than 25 million people since it was first recognized on December 1, 1981, making it one of the most destructive pandemics in recorded history. Antiretroviral treatment reduces both the mortality and the morbidity of HIV infection, but routine access to antiretroviral medication is not available in all countries. An alternative therapy to circumvent this problem is the use of polyanionic substances, which demonstrated a number of promising features as potential anti-HIV drug candidates. In this respect, various SPs (e.g., heparin, DS, dextrin sulfate, cyclo dextrin sulfate, curdlan sulfate, pentosan polysulfate, mannan sulfate, sulfoevernan, and fucoidan) and derivatives thereof (e.g., O-acylated heparin, polyacetal polysulfate, polyvinyl alcohol sulfate, and modified cyclo dextrin sulfates) have been found to inhibit HIV replication in vitro at concentrations that are up to 10 000-fold lower than the cytotoxic concentration [2,71]. [Pg.271]

The assay starts 5 days after cell preparation. Compounds are added to the medium in a final concentration of 101 i M with 6 to 8 replicae per compound, and added anew with each change of medium over a total period of 8 days. The concentration can be varied according to the expected potency of the drug studied. An untreated control group as well as standard compound groups are always included. As standard compound, pentosane polysulfate to check for matrix increase, or retinoic acid to cause matrix decrease, can be applied. [Pg.244]

Waters Q-8HR (strong anion exchange, 8 (jl particles) and DEAE-8HR(weak anion exchange, 8 fi particles) Pentosan polysulfate, dextran sulfate /3-lactoglobulins A and B, a-lactalbumin, soybean trypsin inhibitor (STI) 38... [Pg.385]

Gadam, S. D., and Cramer, S. M. (1994). Salt effects in anion exchange displacement chromatography Comparison of pentosan polysulfate and dextran sulfate as displacers. Chromatographia 39, 409-418. [Pg.413]

SP54 Hypersulfated pentosan polysulfate. Prophylactic antithrombotic -dinicidly used. [Pg.506]

Hemoclar (SP 54) or pentosan polysulfate is a linear cationic polymer of beechwood tree origin which has been used for the prophylaxis of deep venous thrombosis. This agent is developed by Bene Chemical, Munich, Germany. Because of it origin, this agent can be obtained in relatively large quantities and may prove to be useful in various indications. [Pg.506]

Koch P, Hindi S, Landwehr D. Delayed allergic skin reactions due to subcutaneous heparin-calcium, enoxaparin-sodium, pentosan polysulfate and acute skin lesions from systemic sodium-heparin. Contact Dermatitis 199634(2) 156-8. [Pg.1598]

Pentosan polysulfate sodium 250 mg per joint, repeat after 7-10 days Intraarticular... [Pg.377]

Ghosh P. The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment. Semin Arthritis Rheum 1999 28 211-267. [Pg.1703]

Next to kNN, Schirm et al. (51) also applied SIMCA to detect quality differences between different pentosan polysulfate sodium samples. SIMCA succeeded in discriminating samples from two different manufacturers. A 5% incorrect classifications occurred, which is, however, lower than the 10% misclassification obtained from kNN. [Pg.314]

A. Baici, P. Salgam, K. Fehr, and A. Boni. Inhibition from polymorphonuclear leucocytes by gold sodium thiomalate and pentosane polysulfate (SP-54). Biochem. Pharmacol. 30 703 (1981). [Pg.334]

The development of effective treatments for TSE diseases remains problematic. A number of compounds have been identified that can prolong the lives of scrapie-infected rodents if administered before or near the time of infection. These compounds include various polyanions (e.g., pentosan polysulfate (Kimberlin and Walker, 1986 Lado-... [Pg.162]

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