Sodium gold thiomalate

Gold compounds can be effective for active RA and may delay or prevent erosive progression of joints in some patients. Gold sodium thiomalate (24), and aurothioglucose (23) are available as injectable preparations. An oral preparation is also available, but is less effective and frequently causes diarrhea. Injectable gold is adrninistered in 10-mg amounts as a test dose, followed by 25 mg once weekly for two weeks, then 50 mg weekly for 20 weeks. 

The exact mechanism of action of the gold compounds (for example, gold sodium thiomalate, aurothioglucose, and auranofin) in the suppression or prevention of... 

GOLD COMPOUNDS. Aurothioglucose and gold sodium thiomalate are given intramuscularly, preferably in the upper outer quadrant of the gluteus muscle. The nurse gives auranofin orally. 

Shaw, C.F. Ill, Laib, J.E., Savas, M.M. and Petering, D.H. (1990) Biphasickinetics of aurothionein formation from gold sodium thiomalate a novel metallochromic technique to probe zinc (2 + ) and cadmium(2 +) displacement from metallothionein. Inorganic Chemistry, 29, 403-408. 

Turkall, R.M. (1979) Gold sodium thiomalate selected aspects of metabolism and distribution. Ph. D. Thesis, University of Ohio. 

Gold is used therapeutically in chronic inflammations as rheumatic arthritis (Ishida and Orimo 1994). The dose is given in the form ofa gold complex, such as gold sodium thiomalate and Auranofin toxic effects due to overdoses may appear. The most common method to monitor the therapeutic dose in serum or urine is GF-AAS. 

Robinson, C.J., Balazs, T., and Egorov, I.K., Mercuric chloride-, gold sodium thiomalate-, and D-penicillamine-induced antinuclear antibodies in mice. Toxicol. Appl. Pharmacol., 86, 159, 1986. 

Rheumatoid arthritis (aurothioglucose) IM Initially, 10 mg, then 25 mg for 2 doses, then 50 mg weekly thereafter until total dose of 0.8- Iggiven. If patient is improved and there are no signs of toxicity, may give 50 mg at 3-to 4-wk intervals for many months. Rheumatoid arthritis (gold sodium thiomalate) IM Initially, 10 mg, then 25 mg for 2nd... 

Parenteral 50 mg/mL, 25 mg powder for SC injection Gold sodium thiomalate (generic, Aurolate)... 

Gold sodium thiomalate provides a stimulus for liver, kidney and possibly other cells to change the body distribution of zinc and copper. Proteins such as metalloproteins, superoxide dismutase and metallothioneins19 help the cell carry out this task. These essential metals are important in the physiological processes relevant to rheumatoid arthritis, and thus it also appears possible that the gold complexes may mediate their antiarthritic activity through an effect on the metabolism of zinc and copper. 

Anakinra (Kineret) Gold sodium thiomalate (Myochrysine)... 

Gold sodium thiomalate Myochrysine Similar to aurothioglucose. Similar to aurothioglucose. 

A. Baici, P. Salgam, K. Fehr, and A. BonL Inhibition from polymorphonuclear leucocytes by gold sodium thiomalate and pentoaaiie polysulfate (SPL54). Blochem. Pharmacol 50 703 (1981). 

A 63-year-old woman with rheumatoid arthritis was given intramuscular gold sodium thiomalate and began to have nausea, vomiting, anorexia, and watery diarrhea (71). A year later the watery diarrhea became more frequent (more than 10 times within a day) and she developed proteinuria. Biopsies from the stomach, duodenum, and kidney showed systemic amyloidosis. This was a rare case of secondary systemic amyloidosis associated with rheumatoid arthritis. It is not clear from the report what the role of gold was in this case. 

Smith PR, Brown GM, Meyers OL. An open comparative study of auranofin vs. gold sodium thiomalate. J Rheumatol Suppl 1982 8 190-6. 

Prupas HM. Stroke-hke syndrome after gold sodium thiomalate induced vasomotor reaction. J Rheumatol 1984 ll(2) 235-6. 

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