Allergic skin reactions

Glucocorticoid ointments are used to treat allergic skin reactions locally. They should be applied only for limited periods to avoid trophic damage to the skin such as thinning (paper skin). 

Headache, nausea, vomiting, abdominal pain, crystalluria Gastrointestinal disturbances, allergic skin reactions, headache, anorexia, glossitis, hypersensitivity... 

Anorexia, nausea, vomiting, epigastric discomfort, heartburn, hypoglycemia Anorexia, nausea, vomiting, epigastric discomfort, heartburn, diarrhea, hypoglycemia, allergic skin reactions... 

No serious side effects are reported by large clinical studies of ginkgo (Field and Vadnal 1998). Adverse effects resulting from improper dosage have also not been reported (Gruenwald et al. 1998). Mild gastrointestinal symptoms may occur or allergic skin reactions, albeit rarely. Other potential side effects are headaches, dizziness, and palpitations. However, some studies have reported adverse effects to be the same as that of... 

On the skin, concentrated solutions may cause irritation and systemic intoxication. Allergic skin reactions are rare but have been reported. Men accidently exposed to 85% water-wettable powder as a dust complained of burning and irritation of the skin but recovered in a few hours without any treatment except bathing. Their blood cholinesterase levels were only slightly depressed. ... 

Toxicology. NRL causes allergic skin reactions of type I (immediate-type) and type IV [delayed-type hypersensitivity (DTH)]. 

Cyproheptadine has antianaphylactic activity that is associated with its ability to slow down the release of histamine and other mediators from fat cells. It is mainly used for treating bronchial asthma attacks, allergic bronchitis, rhinitis, and allergic skin reactions as well as in adjuvant therapy for anaphylactic reactions. Synonyms of this drug are periactin and vimicon. 

Reexposure There is limited information to support any recommendations for reexposure to lepirudin. Of 13 patients reexposed in 2 studies, one experienced a mild allergic skin reaction during the second treatment cycle. 

Gl disturbances (eg, nausea, epigastric fullness, heartburn) are the most common reactions. Other adverse reactions may include hypoglycemia, disulfiram-like reactions allergic skin reactions eczema pruritus erythema urticaria photosensitivity reactions leukopenia thrombocytopenia aplastic anemia agranulocytosis hemolytic anemia pancytopenia weakness paresthesia tinnitus fatigue dizziness vertigo malaise elevated liver function tests. 

Apart from possible symptoms of hypoglycemia adverse effects include lipohypertrophy from repeated injections in the same subcutaneous area and localized allergic skin reactions as well as generalized allergic reactions. 

Adverse effects that are encountered frequently include transient nausea, flushing and allergic skin reactions. 

A hypersensitivity reaction, manifested asextrapyramidal symptoms (EPS) such as muscle rigidity and allergic skin reactions, occurs rarely. 

There appears to be little difference between benzodiazepines and kava extract in anxiolytic activity. However, kava extracts seem to have fewer side effects. Two studies with more than 3000 patients each found unwanted events in about 2% of patients during treatment with kava extract. The more frequently reported side effects were gastrointestinal complaints, allergic skin reactions, headache, and photosensitivity (Pittler and Ernst, 2000). There have been isolated reports of hepatotoxicity and acute liver failure (Escher et ah, 2001). Kava may potentiate the sedative effects of other medications including barbiturates and benzodiazepines. Kava can also cause behavioral disinhibition in a minority of individuals, including children. The most common problem, which is usually associated with persistent and excessive usage, is a scaly skin rash called kava dermopathy, which is reversible. 

Adverse effects include metallic or bitter after-taste, nausea, vomiting, allergic skin reaction, irritability, hallucinations, depression, amnesia and confusion. 

Side effects such as palpitation, restlessness and finger tremor may occur in isolated cases, flushing, headache, sleep disturbances, nausea, ventricular disturbances or angina pectoris and allergic skin reactions have been observed. 

Adverse reactions include visual disturbances (transient, at the beginning of therapy), nausea and epigastric bloating (rare) and diarrhoea. Hypersensitivity including allergic skin reactions, thrombocytopenia, leucopenia, agranulocytosis, haemolytic anaemia, vasculitis, cholestatic jaundice and hepatitis. 

Adverse effects include haemolysis which is most common and dose related. Patients with G-6-PD deficiency are more susceptible. Nausea, vomiting, anorexia, headache, methaemoglobinaemia, drug fever, allergic skin reactions, insorrmia and paresthesia. Rarely hepatitis and agranulocytosis. 

Compounds (I) through (IV) were assayed for their cytotoxic and allergenic potential on guinea pigs, which are effective indicators of contact allergenicity in humans (10). The same compounds were also tested on Tenebrlo sp. (mealworm beetles), an experimental Insect used to test the potential of insecticides. Geranyl-benzoquinone proved to be a very potent elicitor of allergic skin reactions as well as a potent insecticide (10). 

The most common adverse effects in patients treated with this drug are hot flushes, which resemble those experienced by menopausal patients. They tend to be mild, and disappear when the drug is discontinued. There have been occasional reports of eye symptoms due to intensification and prolongation of afterimages. These are generally of short duration. Headache, constipation, allergic skin reactions, and reversible hair loss have been reported occasionally. 

Metamizol is relatively free of acute side-effects but in rare cases may induce severe and life-threatening allergic reactions such as agranulocytosis, allergic skin reactions and allergic shock. Therefore, the compound is not used in the UK, US or Scandinavian countries. 

Contact allergy to glucocorticoids is not rare in patients with atopic dermatitis. In patients with known contact allergy to budesonide, allergic skin reactions can also occur when inhaled forms of the drug are used, as shown by a randomized, double-bhnd, placebo-controlled study in 15 non-asthmatic patients with budesonide hypersensitivity on patch testing (101). In four of seven patients who used inhaled budesonide, there was reactivation of the 6-week-old patch test sites and they had new distant skin lesions. No flare-up reactions were observed in the other 11 patients (three had used inhaled budesonide and eight placebo for 1 week). None of the patients developed respiratory symptoms spirometry and peak expiratory flow rates remained normal. 

Allergic skin reactions, for example urticaria, can occur. Since the first 13 amino acids in the corticotropin peptide are the same as in MSH, treatment with corticotropin can occasionally cause hyperpigmentation. The shorter peptide chain in tetracosactide can even cause rather more pronounced melanocyte-stimulatory effects. Long-term treatment with depot tetracosactide has itself caused melanoderma (SED-12, 980) and, in one series of 41 patients, there was hyperpigmentation in 3 of them (SEDA-1,281). 

Allergic skin reactions have been described with all sulfonylureas. They include pruritic rashes, erythema nodosum, urticaria, blisters (100), erythema multiforme, exfoliative dermatitis, Quincke s edema, erythroderma, and itching, while lichenoid drug reactions with ulceration have occurred after chlorpropamide and tolazamide (124). More generalized hypersensitivity reactions may prove fatal, but rarely. 

Phenothiazine derivatives have found many applications in todays chemical industry they have been and are used primarily as dyestuffs, antioxidants and in pharmaceutical preparations. This application is due to the discovery of their neuroleptic activity (1 ) (e.g. Chlorpromazine), but allergic skin reactions and ocular opacity are known to occur during therapy. 

Toxic solvents, such as methyl alcohol, benzene, and chlorinated hydrocarbons, can penetrate the skin through cuts and abrasions. On contact, these solvents cause chronic dermatitis and allergic skin reactions in susceptible individuals. 

Caution Potassium dichromate is corrosive and can cause burns. Avoid contact with eyes, skin, and clothing. In case of contact, flush eyes and skin with water. Potassium dichromate can also cause allergic skin reactions the dust can cause irritation. Mixing should be performed in a well-ventilated area using gloves, goggles, and aprons. Potassium dichromate is a suspected carcinogen. 

Kuzmina, N., Nyren, M., Loden, M., Edlund, F., and Emtestam, L., Effects of pre-treatment an emollient containing urea on nickel allergic skin reactions, Acta Derm. Venereol., 9, 85, 2005. 

Several scientific studies provide evidence of the traditional use of parsley in medicine. Food plants of the Apiaceae plant family such as parsley, carrots and celery contain a group of bioactive aliphatic C17-polyacety-lenes, which were shown to be highly toxic towards fungi, bacteria and mammalian cells and to display neurotoxic, anti-inflammatory and antiplatelet aggregatory effects and to be responsible for allergic skin reactions in a study by Christensen and Brandt (2006). The effect of these polyacetylenes towards human cancer cells, their human bioavailability and their ability to reduce tumour formation in a mammalian in vivo model indicate that they may be beneficial for health. 

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