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Interstitial cystitis

Interstitial cystitis Interstitial-free steels Intersystem crossing Intestinal flukes... [Pg.518]

Antithrombotic prophylactic in Europe, for interstitial cystitis in the United States Animal models to treat osteoarthritis, preclinical studies as anticancer agent, inhibits metastasis and angiogenesis 1, 32-37... [Pg.286]

MG Waters, JF Suleskey, LJ Finkelstein, ME Van Overbeke, VJ Zizza, M Stommel. Interstitial cystitis a retrospective analysis of treatment with pentosan polysulfate and follow-up patient survey. J Am Osteo Assoc 100 S13-S18, 2000. [Pg.309]

Dimethyl Sulfoxide [DMSO] (Rimso-50) [GU Agent] Uses Interstitial cystitis Action Unknown Dose Intravesical, 50 mL, retain for 15 min repeat q2wk until relief Caution [C, ] Contra Component sensitivity Disp Soln SE Cystitis, eosinophilia, GI, taste disturbance Interactions -1-Effects OF sulindac EMS May cause garlic/onion taste in mouth OD Acute effects unlikely... [Pg.135]

Mechanism of Action An interstitial cystitis agent that exerts topical analgesic effect on urinary tract mucosa. Therapeutic Effect Relieves urinary pain, burning, urgency,... [Pg.968]

Granulomatous interstitial nephritis (SEDA-12, 94) and two cases of interstitial cystitis have been described during long-term treatment with allopurinol (SEDA-21,108). [Pg.81]

Intravesical instillation of BCG has been nsed to treat superficial bladder carcinoma and interstitial cystitis. Many reports have confirmed the efficacy of BCG in the treatment of transitional cell bladder cancers and have delineated its adverse effects (SEDA-12, 273) (SEDA-13, 278) (SEDA-15, 344) (SEDA-16, 375) (SEDA-17, 366) (SEDA-18, 328) (SEDA-20, 287) (SEDA-21, 328) (SEDA-22, 336). The exact mechanism of its antitumor activity is unknown, but live BCG provokes an inflammatory response that includes activation of macrophages, a delayed hypersensitivity reaction, and stimulation of T and B lymphocytes and natural killer cells. [Pg.397]

There have been several reports of erythematous blistering skin eruption of the palms and soles affecting patients treated with intravesical mitomycin. This has been attributed to contact dermatitis, but more widespread skin involvement and an association with eosinophilic interstitial cystitis suggest that it may be a more generalized allergic reaction (16-20). [Pg.2361]

Dimethyl sulfoxide has also been investigated as a potential therapeutic agent in conditions such as scleroderma, interstitial cystitis, rheumatoid arthritis, and acute musculoskeletal injuries, and as an analgesic. It has also been recommended for the treatment of anthracycline extravasation and has been investigated as a potential cryoprotectant. ... [Pg.250]

Included in the FDA Inactive Ingredients Guide (IV infusions, SC implants, and topical preparations). Available in the USA as a 50% solution for irrigation in the treatment of interstitial cystitis. Also available in Canada as a 70% solution for use as a topical antifibrotic and in Germany as a topical gel containing 10% dimethyl sulfoxide for the treatment of musculoskeletal and joint disorders. Included in topical formulations of idoxuridine and diclofenac licensed in the UK. [Pg.251]

A 2.16% dimethyl sulfoxide solution in water is iso-osmotic with serum. Dimethyl sulfoxide has been used as a 50% aqueous solution for instillation into the bladder in the treatment of interstitial cystitis it has also been tried clinically for a wide range of indications, including cutaneous and musculoskeletal disorders, but with little evidence of beneficial effects. [Pg.251]

Trade name Elmiron (Ortho-McNeil) Indications Bladder pain, interstitial cystitis Category Analgesic, urinary Half-life 4.8 hours... [Pg.449]

Interstitial cystitis is a chronic inflammation of the bladder not caused by an infection. It primarily affects middle-aged women. The symptoms include frequent, painful urination hematuria and diminished urinary capacity. Although the cause of this condition is unknown, I believe it usually has an autoimmune component and/or one relating to food allergies. In this case, eliminating possible food triggers (including such common ones as wheat, dairy, citms, beef, and soy) did not seem to result in any major improvements. [Pg.39]

Dimethylsulphoxide is a universal solvent but can cause itching erythema and uticaria when applied to skin. However, it has been used medicinally in bladder instillations (at 50% in water) for interstitial cystitis, and is a vehicle for idoxuridine for herpes infections (though is of little value). Together with acetone, DMSO is a class 3 solvent under the FDA guidance, not known as a human health hazard at levels normally expected in pharmaceuticals and which can thus be limited by appropriate GMP practices. [Pg.421]

The lower urinary tract consists of the bladder, urethra, urinary or urethral sphincter, and the surrounding musculofascial structures including connective tissue, nerves, and blood vessels. The urinary bladder is a hollow organ composed of smooth muscle and connective tissue located deep in the bony pelvis in men and women. The urethra is a hollow tube that acts as a conduit for urine flow out of the bladder. The interior surface of both the bladder and urethra is lined by an epithelial cell layer termed transitional epithelium, which is in constant contact with urine. Previously considered inert and inactive, transitional epithelium may actually play an active role in the pathophysiology of many lower urinary tract disorders, including interstitial cystitis and UI. The urinary or urethral sphincter is a combination of smooth and striated muscle within and surrounding the most proximal portion of the urethra adjacent to the bladder in both men and women. This is a functional but not anatomic sphincter that includes a portion of the bladder neck or outlet as well as the proximal urethra. [Pg.1548]

Donzelot and Kaufmann found that heparin ameliorated bad cases of rheumatism, supposedly by an antiexudative action, but Burkl suggested that it acts by the inhibition of hyaluronidase activity. The action of heparin in rheumatism is an example of its antiinflammatory influence on connective tissue. Other such examples are its ameliorating effect in thrombophlebitis and its action in interstitial cystitis. ... [Pg.644]

Pentosan polysulfate sodium is an interstitial cystitis agent that adheres to and may protect the mucosal membrane of the bladder. It is indicated in relief of bladder pain or discomfort associated with interstitial cystitis. [Pg.559]

Whereas in the treatment of interstitial cystitis methylsulfonylmethane seems to be more effective than dimethylsulfone because of its better inhibition of cell growth (Layman 1987, Childs 1994), chronic bronchitis was treated with N-acetylcysteine in humans (Stey et al. 2000). [Pg.1310]

Childs SJ (1994) Dimethyl sulfone (DMSO2) in the treatment of interstitial cystitis. Urol Clin North Am 21 85-88. [Pg.1316]

Fibrose. Fibrezym. Hemoclar. Thrombo-cid. CB 8061. PZ 68. SP 54 [37300-21-3] Anticoagulant, antiinflammatory agent. Used in the treatment of interstitial cystitis. Plasminogen activator-releasing agent. Shows antithrombotic and antineoplastic activity. Inhibits accumulation of protease-resistant prion protein in a scrapie-infected cell line. [a]o -57 (Na salt). Used as sodium salt (Pentosan polysulfate sodium, BAN, INN, USAN). [Pg.965]

C. lavazzo, S. Athanasiou, E. Pitsouni, and M.E. Falagas, Hyaluronic acid An effective alternative treatment of interstitial cystitis, recurrent urinary tract infections, and hemorrhagic cystitis , Eur. Urol, 51 (6), 1534-1540, discussion 1540-1541, 2007. [Pg.189]

A device with shape memory technology and osmotic delivery has been developed to treat patients who suffer from a painful bladder condition known as interstitial cystitis/bladder pain syndrome (TARIS Biomedical Inc., MA). The device was made of a dual-lumen silicone catheter with one lumen loaded with lidocaine, which continuously leached out as contacted with urine. The second lumen of the device contains superelastic nitinol wire in a predefined form, which provides the... [Pg.279]

Nickel, J. C., et al. (2012). Continuous intravesical lidocaine treatment for interstitial cystitis/ bladder pain syndrome safety and efficacy of a new drug dehvery device. Science Translational Medicine, 4(143), 143ral00. [Pg.294]

Nonsteroidal anti-inflammatory dmg-induced cystitis is caused by indomethacin. Oral indomethacin treatment in mice caused penetration of lanthanum nitrate through intercellular areas of the epithelium, as well as an excess of mast cells. Hence, indomethacin resulted in histopathologic findings typical of interstitial cystitis, such as leaky bladder epithelimn and mucosal mastocytosis (Cetinel, Cetinel et al. 2003). [Pg.172]


See other pages where Interstitial cystitis is mentioned: [Pg.112]    [Pg.1052]    [Pg.171]    [Pg.95]    [Pg.959]    [Pg.959]    [Pg.112]    [Pg.253]    [Pg.1052]    [Pg.1131]    [Pg.39]    [Pg.39]    [Pg.1551]    [Pg.645]    [Pg.646]    [Pg.523]    [Pg.524]    [Pg.253]    [Pg.348]    [Pg.269]   
See also in sourсe #XX -- [ Pg.29 ]

See also in sourсe #XX -- [ Pg.172 ]




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