P388 murine leukemia cell line

The related stannylpyrrole 90, which was reported by Dubac [72], has been used to synthesize the sponge metabolite mycalazol 11 (91) and related compounds, which have activity against the P388 murine leukemia cell line [74]. 

Kraker AJ and Moore CW (1988). Elevated DNA polymerase beta activity in a cis-diammine-dichloroplatinum(n) resistant P388 murine leukemia cell line. Cancer Lett, 38, 307-314. 

Pericosines A (145) and B (146) were cytotoxic on the P388 murine leukemia cell line, showing ICsoof 0.12 and 4.0 ig/ml respectively [179]. 

Nakiterpiosin is a marine sponge metabolite that exhibits potent cytotoxicity against the P388 murine leukemia cell line (GI50 10 ng/mL). It was the first C-nor-... 

Aburatubolactam A, a marine tetramic acid macrolactam, isolated by Uemura and co-workers in 1996 from the cultured broth of a Streptomyces sp., SCRC-A20, separated from a mollusk collected near Aburatubo, Kanagawa Prefecture, Japan. Aburatubolactam A possess cytotoxic activity against P388 murine leukemia cell lines (IC50 = 26... 

To ascertain drug activity, the concentration that inhibits cell growth by 50 % (ICso) was evaluated. The evaluation was performed on L1210 or P388 murine leukemia cell lines which were maintained in serial cultures as described by Gutierrez et al. . Cell cultures were incubated with and without drug in slanted test tube racks at 37 C in an atmosphere of 95 % air, 5 % CO2 and 95 % humidity. After 72 h incubation time, the cells were counted and ICso values obtained from plots of cell survival versus drug concentration. 

The discovery of Taxol is a fruit of a National Cancer Institute (NCI)-sponsored project on identification of antitumor agents from natural resources. Bioassay-guided fractionation led to the isolation of this unique compound from Taxus bre-vifolia (pacific yew). Wani et al. also identified another famous antitumor natural product camptothecin. Unlike camptothecin, which was abandoned in the phase of clinical trial because of its severe toxicity, Taxol was almost discarded at the preliminary phase because it only exhibited moderate in vitro activity toward P388, a murine leukemia cell line that was used in the standard evaluation system by NCI researchers at that time. However, it was rescued by a subsequent finding of its strong and selective antitumor activities toward several solid tumors, and more... 

Pettit GR, Barton DHR, Herald CL, Polonsky J et al. 1983 Antineoplastic agents. 97. Evaluation of limonoids against the murine P388 lymphocytic leukemia cell line. J Nat Prod 46 379-390... 

Biochemical Studies Pironetin showed antitumor activity against a murine tumor cell line, P388 leukemia, transplanted in mice [4], and induced the... 

Methyl-1,3-dihydropyrrolo[ 1,2-c]thiazole-6,7-biscarbamates have been described as active compounds against murine P388 lymphocytic leukemia <87JMC2109>. Several 5-aryl-2,3-dihydro-pyrrolo[2,l-fe]thiazole-6,7-dimethanol-6,7-bis(isopropylcarbamate)s were tested for growth inhibitory activity with the HL-60 human promyelocytic leukemia cell line. The 5-phenyl, 5-(4-fluorophenyl), and 5-(3,4-dichlorophenyl) have antileukemic activity. These compounds were also cytotoxic to HT-29 human colon carcinoma cells <88JMC1427>. 

Murraya koenigii (L.) Spreng (Rutaceae) was evaluated for its in vitro cytotoxic effects against MCF 7, P388 (murine leukemia) and Hela cells. The results showed that both, the EO and its main compound carbazole alkaloids have signi cant antiproliferative effects on all three tested cell lines in a dose- and time-dependent manner (Nagappan et al., 2011). 

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