P388 murine

The related stannylpyrrole 90, which was reported by Dubac [72], has been used to synthesize the sponge metabolite mycalazol 11 (91) and related compounds, which have activity against the P388 murine leukemia cell line [74]. 

Yamaoka T, Hanada M, Ichii S, Morisada S, Noguchi T, Yanagi Y. (1999) Uptake and intracellular distribution of amrubicin, a novel 9-aminoanthra-cycline, and its active metabolite amrubicinol in P388 murine leukemia cells. Jpn J Cancer Res 90 685-690. 

Many of the N-1 derivatives described above show antitumor activity. Compound 56 is active against P388 murine lymphocytic leukemia at a dose of 6.0 mg/kg/day x 8 (i.p.), giving an ILS of 82%, and compound 57 shows an improvement in the therapeutic index of vinblastine. Compound 58 was also active against P388 at very low doses (0.1 mg/kg/day... 

Corey and Roberts reported a total synthesis of the dysidiolide 46, a marine sponge metabolite with biological activities against A-549 human lung carcinoma and P388 murine leukemia cancer cell lines20 (Scheme 4.3p). The unwanted alcohol (47) was converted to the ketone 48 via Dess-Martin periodinane oxidation. The asymmetric reduction of 48 with the CBS catalyst 28b efficiently gave the alcohol 49, which was transformed into the dysidiolide 46 via photochemical oxidation. 

Peloruside A 14 (Scheme 6.1 Part 2) was isolated from a New Zealand Mycale hentschei marine sponge and initially showed activity against P388 murine leukaemia cells at 10 ng/mL.98 Peloruside s cytotoxicity profile and structural similarity to bryostatin led to the examination of protein kinase C (PKC) as a possible mode of action.242 This was determined to be incorrect and it was soon established that the remarkable activity of peloruside was through the stabilisation of microtubules at a site distinct from the taxoid site.243... 

Inhibition of in vitro proliferation of P388 murine leukemia 10%... 

Microcyclamide 342, isolated from the cultured cyanobacterium Microcystis aeruginosa, is a cytotoxic cyclic hexa-peptide alkaloid containing an imidazole ring system <2000JNP1315>. It showed moderate cytotoxicity against P388 murine leukemia cells. 

Cytotoxicity Issues. In-vivo hemolysis has been observed with parenteral administration of all of the parent CDs. In-vitro studies with human erythrocytes have demonstrated that the damaging effect of the CDs is in the order p-CD > ot-CD > y-CD. This cellular destruction has also been observed in studies with human skin fibroblasts and intestinal cells, P388 murine leukaemic cells, E. coli bacterial cells, and immortalized human corneal epithelial cells.f " Mechanistic studies suggest that CDs extract either cholesterol (p-CD and y-CD) or phospholipids (a-CD) from the cell membrane causing small pores which allow leakage and eventually lead to cell lysis. 

Ramu, A.. Fuks, Z., Gatt, S., and Glaubiger. D. (1984) Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate. Cancer Research, 44 (1). 144—148. 

Kraker AJ and Moore CW (1988). Elevated DNA polymerase beta activity in a cis-diammine-dichloroplatinum(n) resistant P388 murine leukemia cell line. Cancer Lett, 38, 307-314. 

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