Polymerase beta

Bennett, R.A., Wilson, D.M., 3rd, Wong, D., and Demple, B. (1997) Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. Proc. Natl. Acad. Sci. USA 94, 7166-7169. 

Ochs K, Sobol RW, Wilson SH, Kaina B (1999) Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Cancer Res 59 1544-1551... 

Available evidence indicates that PCNA is also involved in DNA nucleotide excision-repair. This role is exemplified by the demonstration that PCNA can be found associated with chromatin at all phases of the cell cycle after ultraviolet irradiation in vitro (Toschi and Bravo, 1988). Recently it was shown that not only DNA polymerase delta but DNA polymerases beta and epsilon are also involved in the base excision repair subpathways (Dianov et al., 1999). In addition, PCNA may be expressed by noncycling cells in vivo which are undergoing DNA repair (Hall et al., 1993). 

Matsumoto, Y. and Kim, K. (1995) Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair. Science, 269, 699-702. 

Gu, H., Marth, J.D., Orban, P.C., Moss-mann, H., and Rajewsky, K. (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265, 103-106. 

Pelletier, Huguette Sawaya, Michael R. Kumar, Amalendra Wilson, Samuel H. and Kraut, Joseph (1994). Structures of Ternary Complexes of Rat DNA Polymerase Beta, a DNA Template Primer and ddCTP. Science 264 1891. 

Oelschlaeger P, Klahn M, Beard WA et al (2007) Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations improved accuracy in studies of structural features and mutational effects. J Mol Biol 366 687-701. doi 10.1016/J.Jmb. 2006.10.095... 

Podlutsky AJ, Dianova, n, Wilson SH, Bohr VA, Dianov GL. DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts. Biochemistry 2001 40 809-813. 

Prasad R, Beard WA, Strauss PR, Wilson SH. Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism. J. Biol. Chem. 1998 273 15263-15270. Prasad R, Bebenek K, Hou E, Shock DD, Beard WA, Woodgate R, Kunkel TA, Wilson SH. Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. J. Biol. Chem. 2003 278 29649-29654. 

Kraker AJ and Moore CW (1988). Elevated DNA polymerase beta activity in a cis-diammine-dichloroplatinum(n) resistant P388 murine leukemia cell line. Cancer Lett, 38, 307-314. 

Radhakrishnan, R., SchKck, T. Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta s closing, Proc. Natl. Acad. Sci. U.S.A. 2004,101, 5970-5. 

Sawaya, M. R., Prasad, R., Wilson, S. H., Kraut, J., and Pelletier, H. (1997). Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA evidence for an induced fit mechanism. Biochemistry 36(37), 11205-11215. 

Engel ML, Ray DS. The kinetoplast structure-specific endonuclease 1 is related to the 5 exo/endonu-dease domain of bacterial DNA polymerase I and colocalizes with the kinettqrlast topoisomerase II and DNA polymerase beta during replication. Proc Nad Acad Sd USA 1999 96(15) 8455-60. 

Torri AF, Englund PT. A DNA polymerase beta in the mitochondrion of the trypanosomatid Crithidia fasciculata. J Biol Chem 1995 270(8) 3495-7. 

Saxowsky TT, Choudhary G, Klin jeil MM et al. Trypanosoma brucei has two distinct mitochondrial DNA polymerase beta enzymes. J Biol Chem 2003 8 8. 

Allinson, S. L., Dianova, I. I., and Dianov, G. L. (2001). DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts. EMBO J. 20, 6919-6926. 

Bergoglio, V., Pillaire, M.J., Lacroix-Triki, M., Raynaud-Messina, B., Canitrot, Y., Bieth, A., Cares, M., Wright, M., Delsol, G., Loeb, L. A., Cazaux, C., and Hoffmann, J. S. (2002). Deregulated DNA polymerase beta induces chromosome instability and tumorigen-esis. Cancer Res. 62, 3511-3514. 

Caldecott, K. W., Aoufouchi, S., Johnson, P., and Shall, S. (1996). XRCCl polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase. 

Canitrot, Y, Cazaux, G., Frechet, M., Bouayadi, K., Lesca, C., Salles, B., and HofEmann, J. S. (1998). Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs. Proc. Natl Acad. Sci. USA 95, 12586-12590. 

Kubota, Y, Nash, R. A., Klungland, A., Schar, P., Barnes, D. E., and Lindahl, T. (1996). Reconstitution of DNA base excision-repair with purified human proteins Interaction between DNA polymerase beta and the XRGGl protein. EMBO J. 15,... 

Prasad, R., Beard, W. A., Chyan,J. Y, Maciejewski, M. W., Mullen, G. P., and Wilson, S. H. (1998). Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5 -deoxyribose phosphate lyase activities./. Biol. Chem. 273, 11121-11126. 

Prasad, R., Lavrik, O. I., Kim, S. J., Kedar, P., Yang, X. P., Vande Berg, B. J., and Wilson, S. H. (2001). DNA polymerase beta-mediated long patch base excision repair. Poly(ADP-ribose) polymerase-1 stimulates strand displacement DNA synthesis. 

Prasad, R., Singhal, R. K., Srivastava, D. K., Molina, J. T., Tomkinson, A. E., and Wilson, S. H. (1996). Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis. J. Biol. Chem. 271, 16000-16007. 

Wilson, S. H. (1998). Mammalian base excision repair and DNA polymerase beta. Mutat Res. 407, 203-215. 

Wilson, T. E., and Lieber, M. R. (1999). Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway./. Biol Chem. 274, 23599-23609. 

Esposito, G., Texido, G., Betz, U. A., Gu, H., Muller, W., Klein, U., and Rajewsky, K. (2000). Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally. Proc. Natl. Acad. Sci. USA 97, 1166-1171. 

Alberts IL, Wang Y, Schlick T (2007) DNA polymerase beta catalysis are different mechanisms possible J Am Chem Soc 129 11100... 

Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH Structures of DNA polymerase beta with active-site mismatches surest a transient abasic site intermediate during misincorporation. Mol Cell 2008, 30(3) 315—324. 

M.C., and Shetlar, M.D. (1998) Probing the binding region of the single-stranded DNA-binding domain of rat DNA polymerase beta using nanosecond-pulse laser-induced cross-linking and mass spectrometry. Photochem. Photobiol., 68 (3), 299-308. 

Horton JK, Watson M, Stefanick DF, et al (2008) XRCCl and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell Res 18 48-63 Hutcheson IR, Knowlden JM, Jones HE, et al (2006) Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy. Endocr Relat Cancer 13(suppl 1) S89-S97... 

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