P388 leukemia

Condensation of 594 with alloxan followed by methylation of the presumably formed purino[7,8-g]-6-azapteridine gave 597. Treatment of the latter with alkylamines afforded (87CPB4031) [1,2,4]triazino[2,3-/]purines 598. Compound 597 was active against P388 leukemia. Vascular relaxing effects of 598 were determined, but none showed potent activity (87CPB4031) (Scheme 123). 

Several years ago, a collection of megapotamica found growing in a saltwater marsh near Curitioa, Brazil, was shown to contain a series of compounds which exhibited very high activity jji vivo against mouse P388 leukemia... 

Figure 1. Survival effects for chitin-5FU conjugates(l) against p388 leukemia in mice ip/ip. D5FU=8.3mol%, D5FU=llmol%, (°) 5FU.

Figure 3. Survival effect for a-l,4-polygalactosamine-5FU(3) and partially N-acetylated a-l,4-polygalactosamine-5FU(4) conjugates against p388 leukemia in mice ip/ip. Q 3(Pn=20-60 D5FU=28mol%), 3(Pn=20-60 ...

Dibutyltin glycylglycinate 44 (where R = butyl) is the most active organotin complex against p388 leukemia, but is inactive against L1210 leukemia, B16 melanoma, and Lewis lung carcinoma in mice (212). 

Fig. 8. Antitumor activity of vinepidine, vincristine, and vinblastine against P388 leukemia. Compounds were administered i.p. as their sulfate salts on day I following i.p. inoculation of I X 10 tumor cells.

Effect of Quinacrine on Activity of Vincristine against Vincristine-Resistant P388 Leukemia in Mice... 

Diazopyrazoles and imidazoles are useful intermediates in the synthesis of pyrazolo- and imidazolo-tetrazinones, which have shown anticancer activity, especially the mitozolomide that had curative activity against L1210 and P388 leukemia (84JMC1% 87JMC357). 4-Diazopyrazole are used in the synthesis of C-nucleoside antibiotics such as pyrazolomycin [81JCS(P1)2374]. 

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