P388 murine leukemia cancer cell lines

Kraker AJ and Moore CW (1988). Elevated DNA polymerase beta activity in a cis-diammine-dichloroplatinum(n) resistant P388 murine leukemia cell line. Cancer Lett, 38, 307-314. 

Studies in mice using the murine P388 leukemia sub-line selected for mdrl overexpression and the human colon cancer cell lines that express mdrl (Table 3B) suggest that intracellular pachtaxel derived from breakdown of CT-2103 is less subject to the multidmg resistance pump than is paclitaxel that enters the cell by diffusion of free pachtaxeP. As has been shown for other polymeric dmg conjugates, this is probably due active uptake of the conjugate by tumour cells with breakdown of the PG backbone and release of free paclitaxel at sites distant from the plasma membrane where they cannot be exported by intrinsic plasma membrane pumps. 

The discovery of Taxol is a fruit of a National Cancer Institute (NCI)-sponsored project on identification of antitumor agents from natural resources. Bioassay-guided fractionation led to the isolation of this unique compound from Taxus bre-vifolia (pacific yew). Wani et al. also identified another famous antitumor natural product camptothecin. Unlike camptothecin, which was abandoned in the phase of clinical trial because of its severe toxicity, Taxol was almost discarded at the preliminary phase because it only exhibited moderate in vitro activity toward P388, a murine leukemia cell line that was used in the standard evaluation system by NCI researchers at that time. However, it was rescued by a subsequent finding of its strong and selective antitumor activities toward several solid tumors, and more... 

NSCLC-N6 is a non-smaU-cell lung cancer line developed at Nantes, France KB, nasopharyngeal cancer cells HT-29, colon cancer cells P388/Dox, doxombicin-resistant murine leukemia cells. 

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