Perhexiline maleate

Trade Name Manufacturer Country Year Introduced 

Ethyl formate a-Picoline Sodium hydroxide Maleic acid 

1-Dicvclohexvl-2-(2 -pvridyl)ethanol hydrochloride (5 grams) was dehydrated by heating with 25 ml of concentrated hydrochloric acid at steam bath temperature for 10 minutes. 

70 ml of water were added to the reaction mixture to give the crystalline hydrochloride salt. The product, 1,1-dicvclohexvl-2-(2 -pvridvl)ethylene hydrochloride, was recrystallized from methanol-ethyl acetate to yield a white solid melting at 150°-151.5°C. 

1- Dicyclohexyl-2-(2 -pyridyl)ethylene hydrochloride (15 grams) in 150 ml of ethanol was hydrogenated in the presence of platinum oxide at about 60 pounds per square inch of hydrogen pressure. The product, 1,1-dicyclohexyl-2-(2 -piperidyl)ethane hydrochloride, crystallized from a mixture of methanol and methyl ethyl ketone as a white solid melting at 243° to 245,5°C. 

The hydrochloride salt was neutralized with 10% sodium hydroxide solution and the free base so produced was dissolved in ether. The ether solution was dried over anhydrous magnesium sulfate. Addition of an excess of maleic acid in methanol to the solution yielded the acid maleate salt which melted at 188.5°-191°C. 

Ct-Picollne Sodium hydroxide Maleic acid Hydrogen chloride Hydrogen  

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Committee on Safety of Medicines. Perhexiline maleate (Pexid) adverse reactions. Curr Probl 1983 11. 

Pergonal menotrophin. perhexiline [ban, inn] (perhexlline maleate [ban. usan]) is a dicyclohexylperidine derivative, with VASODILATOR properties and can be used as an antianginal also has DIURETIC properties. It has been discontinued, perhexiline maleate perhexiline. 

Ramu, A.. Fuks, Z., Gatt, S., and Glaubiger. D. (1984) Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate. Cancer Research, 44 (1). 144—148. 

One new drug that appears to be of more than average Interest is perhexiline maleate.70 Like an earlier analog, hexadillne (hexadylamine), this agent Increases both coronary and peripheral blood flow. In contrast to the nitrates, however, doses that markedly lower blood pressure do not... 

Masoni, A., Tomasi, A. M. and Oriani, G. A. (1975) Clinical evaluation of perhexiline maleate in the treatment of patients with chronic coronary insufficiency. men Heart J., 90, 145. 

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