Murine lymphocytic leukemia

Many of the N-1 derivatives described above show antitumor activity. Compound 56 is active against P388 murine lymphocytic leukemia at a dose of 6.0 mg/kg/day x 8 (i.p.), giving an ILS of 82%, and compound 57 shows an improvement in the therapeutic index of vinblastine. Compound 58 was also active against P388 at very low doses (0.1 mg/kg/day... 

Ansamycin antibiotics are probably the most complex organic compounds produced by the genus Streptomyces. In addition to the antibacterial, they also exhibit antiviral effects. Ansamitocin P-3 shows a potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. The compound exhibits a significant activity against P-388 lymphocytic leukemia in mice and both 9PS (murine lymphocytic leukemia) and 9KB (human nasopharyngeal carcinoma) in cell culture systems. [38]. 

In addition to silymarin, hydnocarpin (68) and sinaiticin (96) isolated from Verbascum sinaiticum exhibited cytotoxicity against cultured P-388 (murine lymphocytic leukemia) cells (120). 5 -Methoxyhydnocarpin-D (79) and silybin (1) have been identified as bacterial MDR pump inhibitors (107). 

Berberine chloride was demonstrated to possess significant cytotoxic activity against cultured P-388 (murine lymphocytic leukemia) cells, in addition to three human cancer cell lines BC1 (breast cancer) - EDJ0 2.7 pM) HT-1080 (fibrosarcoma) - ED50 2.4 pM) and KB (nasopharyngeal carcinoma) - EDJ0 8.4 pM)[336]. 

Berberrubine chloride was found to exhibit cytotoxic activity against cultured P-388 (murine lymphocytic leukemia) cells (1.7 pM)[336]. 

Liriodenine was found to be active in the brine shrimp lethality test (LC50 2.03 pg/ml) but was inactive in the 9PS (a chemically-induced murine lymphocytic leukemia) and 9KB (human nasopharyngeal carcinoma) cytotoxicity tests [296],... 

Podophyllotoxin (1), 4 -danethyldeoxypodophyUotoxin (2) and P-apopicro-podophyllin (3) strongly inhibited P-388 (murine lymphocytic leukemia) the IC50 values (concentration at which 50% of cells were killed) were 0.003, 0.005, and... 

Cytotoxicity is denoted by inhibition of human epidermal carcinoma (KB-16), human lung adenocarcinoma (A549), human colon carcinoma (HT-29), and murine lymphocytic leukemia (P-388) cells at half maximal inhibitory concentration (IC50) values of pg/mL. bFor the cell lines tested, an IC50 value of <4 pg/mL is regarded as active. 

Bruceanols D (67), E (68), and F (69) were tested for in vitro cytotoxicity in five human tumor cell lines (KB, A-549, HCT-8, RPMI-7951, TE-671) and a murine lymphocytic leukemia (P-388). The results shown in Table 1 [37], All the compounds showed significant activity in each tested cell lines. 

The bioactivity data for Pseudobersama sterols are given in Table 6. All three sterols exhibited selective activity on the rad52 strain compared with the wild-type RAD+ strain. Ergost-5,24(28)-diene-3p,7a-diol (37) was also tested in P-388 murine lymphocytic leukemia assay and was found to be moderately cytotoxic. 

We have isolated two 3,7-dihydroxysteroidal compounds from S. glutinosa, one known 7-a-hydroxysitosterol and one new l-oxo-7a-hydroxysitosterol (70). According to the literature , cholest-5-ene-3p,7P-diol derivatives showed activity in the P-388 murine lymphocytic leukemia test... 

In 1974, extracts of the tiny ( 5 mm) marine tube worm Cephalodiscus gilchristi collected off South Africa were found to be active in the NCI s primary assay, the murine lymphocytic leukemia P388. Fifteen years of relentless research by Pettit s group culminated in the isolation of 139 mg of the major bioactive component, cephalostatin 1, from 166 kg wet weight of the tube worm, and its structural elucidation. [2] This phase was summarized [3] as follows Interest in such a powerfully antileukemic agent as cephalostatin 1. .. has prompted Americans to dive extensively at a depth of 20 meters to collect... 

P388, murine lymphocytic leukemia UlSO-BCA and BC-l, breast cancer UlSO-COL 2 and COL-2, colon cancer U1S0-LUC I and LU-1, lung cancer UlSO-MEL-2 and MEL-2, melanoma HT<1080 and HT. fibrosarcoma KB, oral epidermoid KB-V, multi drug-resisiani KB KB-3, oral epidermoid carcinoma KB-Vi, durg-resistant KB3 KB-Vi (-fVLB) and KB-VI (-vLB). KB3 in die presence and absence of vinblastine, respectively A 431. epidermoid carcinoma LNCaP, prostate cancer ZR-7S-I, hormone-dependent breast cancer U-373, gliobastoma. 

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