P388 murine leukemia cells

The related stannylpyrrole 90, which was reported by Dubac [72], has been used to synthesize the sponge metabolite mycalazol 11 (91) and related compounds, which have activity against the P388 murine leukemia cell line [74]. 

Yamaoka T, Hanada M, Ichii S, Morisada S, Noguchi T, Yanagi Y. (1999) Uptake and intracellular distribution of amrubicin, a novel 9-aminoanthra-cycline, and its active metabolite amrubicinol in P388 murine leukemia cells. Jpn J Cancer Res 90 685-690. 

Microcyclamide 342, isolated from the cultured cyanobacterium Microcystis aeruginosa, is a cytotoxic cyclic hexa-peptide alkaloid containing an imidazole ring system <2000JNP1315>. It showed moderate cytotoxicity against P388 murine leukemia cells. 

Ramu, A.. Fuks, Z., Gatt, S., and Glaubiger. D. (1984) Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate. Cancer Research, 44 (1). 144—148. 

Kraker AJ and Moore CW (1988). Elevated DNA polymerase beta activity in a cis-diammine-dichloroplatinum(n) resistant P388 murine leukemia cell line. Cancer Lett, 38, 307-314. 

L-1210 and P388 - murine leukemia cells L5178 - mouse lymphoma cells KB - human nasopharyngeal cells A-549 - lung carcinoma cells... 

L1210 cells and epidermoid carcinoma KB cells was also observed for other cystodytins (91JNP1634). A bromo-substituted tetracyclic alkaloid pantherinine 138 has been isolated from the ascidian Aplidium pantherinum, and a moderate cytotoxic activity (ED50 = 4.5 /xg/ml) against P388 murine leukemia cells has been reported by Kim et al. (93JNP1813). 

Pericosines A (145) and B (146) were cytotoxic on the P388 murine leukemia cell line, showing ICsoof 0.12 and 4.0 ig/ml respectively [179]. 

Nakiterpiosin is a marine sponge metabolite that exhibits potent cytotoxicity against the P388 murine leukemia cell line (GI50 10 ng/mL). It was the first C-nor-... 

Amaminols A (236) and B (237) are two bicyclic amino alcohols isolated from an unidentified tunicate from the Amami islands exhibiting moderate cytotoxicity against P388 murine leukemia cells (202). The required key intermediate 240 was obtained in moderate yield and excellent stereoselectivity was observed by treatment of the in sOw-prepared aldehyde 239 with catalytic amounts of the TFA salt of 228. The bicyclo[4.3.0]nonane 240 was then successfully converted further either into amaminol A (236) or amaminol B (237) (Scheme 55). 

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