Leukemia cancer cell lines

Haliclonacyclamine F (25), arenosclerin D (26), and arenosclerin E (27) have been recently isolated from the sponge Pachychalina alcaloidifera endemic in Brazil [26]. The alkaloids 25-27 were isolated from the cytotoxic, antibiotic, and antituberculosis MeOH crude extract of P. alcaloidifera by a series of separations on silica-gel and cyanopropyl-bonded silica-gel columns. The structures of compounds 25-27 were established by the same approach employed for the structural elucidation of haliclonacyclamine E (13) and arenosclerins A-C (14-16) [18], as well as by comparison with NMR data for this last series of alkaloids. The alkaloids 25-27 displayed moderate cytotoxic activity against SF295 (human CNS), MDA-MB435 (human breast), HCT8 (colon), and HL60 (leukemia) cancer cell lines. 

In a similar way, Chen et al. reported DlB-catalyzed an efficient synthesis of 2,3-disubstituted quinoxalines 140. In a one-pot method, internal alkynes 138 and o-phenylenediamines 139 were treated with a mild and inexpensive DIB to afford quinoxalines in good yields (Scheme 31). Among the prepared series of quinoxaline derivatives, one of the trimethoxy-substituted compounds 141 was foxmd to exhibit promising activity against leukemia cancer cell line. Using this simple and one-pot procedure, various therapeutically important quinoxalines can be prepared [47]. 

Usually considered as non-natural amino adds, an inseparable mixture of two long-chain lipidic a-amino acids was isolated from the Brazilian zoanthid Protopaly-thoa variabilis. Both compounds were shown to have potent pro-apoptotic activity against HCT-8 (colon), SF-295 (central nervous system), MDA-MB-435 (breast), and HL-60 (lymphoblastic leukemia) cancer cell lines (Wilke et al, 2010). Synthetic analogs were shown to be less active than the natural compounds. 

HASHIMOTO S, XU M, MASUDA Y, AIUCHI T, NAKAJO S, CAO J, MIYAKOSHI M, IDA Y and NAKAYA K (1999) Beta-hydroxyisovalerylshikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60 cells through a mechanism different from those of Fas and etoposide , J Biochem (Tokyo), 125 17-23. 

Ma I, Maliepard M, Nooter K, Loos WJ, Kolker HJ, Verweij J, Stoter G, Schellens JHM (1998b) Reduced cellular accumulation of topotecan a novel medianism of resistance in a human ovarian cancer cell line. Br ) Cancer 77 1645-1652 MacFarlane DE, O Donnell PS (1993) Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant. Leukemia 7 1846-1851... 

Preliminary in vitro and animal studies of the effects of silymarin and silybinin have been carried out with several cancer cell lines. In murine models of skin cancer, silybinin and silymarin were said to reduce tumor initiation and promotion. Induction of apoptosis has also been reported using silymarin in a variety of malignant human cell lines (eg, melanoma, prostate, leukemia cells, bladder transitional-cell papilloma cells, and hepatoma cells). Inhibition of cell growth and proliferation by inducing a Gx cell cycle arrest has also been claimed in cultured human breast and prostate cancer cell lines. The use of milk thistle in the clinical treatment of cancer has not yet been adequately studied but preliminary trials are under way. 

Several reports have described the anticancer activity of curcumin in a variety of cancer cell lines. In vitro studies have established the activity for curcumin against breast, gastric, hepatic, pancreatic, colorectal, urinary bladder, kidney, prostate, cervical, ovarian, uterine, lung, oral, thymic, and skin cancers. Besides these cancer types, curcumin has shown in vitro therapeutic efficacy against hematological cancers including leukemia, lymphoma, and multiple myeloma. One of our early studies established that the antiproliferative effect of curcumin in human breast cancer cell lines, including hormone-dependent, hormone-independent,... 

The antineoplastic activity of vanadium compounds has been studied for some time. In 1979, the metalocene compound, biscyclopentadienyldichloro-Vanadium(IV), (C5H5)VCI2, was found to have antitumor activity [161], The compound inhibited the growth of various cancer cell lines and the growth of solid tumors in vivo. Vanadium(V) peroxocomplexes with known insulin-mimetic activity were shown to have antitumor activity against murine leukemia cells at that time. Vanadocene compounds are now known to induce apoptosis in cell lines. The apoptotic signal... 

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