Low-density lipoproteins oxidized

Douglas SD (2001) Methadone may promote HIV replication study. AIDS Alert 16 120 Dreyer EB, Kaiser PK, Offermann IT, Lipton SA (1990) HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 248 364-367 Dunn S, Vohra RS, Murphy JE, Homer-Vanniasinkam S, Walker JH, Ponnambalam S (2008) The lectin-like oxidized low-density-lipoprotein receptor a pro-inflammatory factor in vascular disease. Biochem J 409 349-355... 

KAPLAN M and AVIRAM M (1999) Oxidized low density lipoprotein atherogenic and proinflammatoiy characteristics during macrophage foam cell formation. An inhibitory role for nutritional antioxidants and serum paraoxonase Clinical Chemistry Laboratory Medicine 37,111-9,1. 

Darley-Usmar, V.M., Severn, A., O Leary, V.J. and Rogers, M. (1991). Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content. Biochem. J. 278, 429-434. 

OH-Ade 8-hydroxyadenine 6-OHDA 6-hydroxyguanine 8-OH-dG 8-hydroxydeoxyguanosine also known as 7,8-dihydro-8-0X0-2 -deoxyguanosine 8-OH-Gua 8-hydroxyguanine OHNE Hydroxynonenal 4-OHNE 4-hydroxynonenal OT Oxytocin OVA Ovalbumin ox-LDL Oxidized low-density lipoprotein... 

Shimaoka T, Kume N, Minami M, et al. Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages. J Biol Chem 2000 275(52) 40663-40666. 

Oxidized low-density lipoprotein (LDL) may play a key role in the initiation and progression of atherosclerosis. Risk factors for elevated levels of oxidized LDL are not well established and may be important in identifying individuals who may benefit from antioxidant supplementation or interventions to reduce oxidant stress. 

Hoogerbrugge N, Zillikens MC, Jansen H, Meeter K, Deckers J W, Birkenhager JC (1998) Estrogen replacement decreases the level of antibodies against oxidized low-density lipoprotein in postmenopausal women with coronary heart disease. Metabolism 47 675-680... 

Uint L, Gebara OC, Pinto LB, Wajngarten M, Boschcov P, da Luz PL, Gidlund M (2003) Hormone replacement therapy increases levels of antibodies againstheatshock protein 65 and certain species of oxidized low density lipoprotein. Braz J Med Biol Res 36 491-494... 

Ramprasad, M.R, et al., Cell surface expression of mouse macrosialin and humand CD68 and their role as macrophage receptors for oxidized low density lipoprotein, Proc. Natl. Acad. Sci. USA, 93, 14833, 1996. 

A. Blair, P. W. Shaul, I. S. Yuhanna, P. A. Conrad, and E. J. Smart. Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation. J. Biol. Chem. 274 32512-32519 (1999). 

Boullier, A., GUlotte, K.L., Horkko, S., Green, S.R., Friedman, P., Dennis, E.A., Witzmm, J.L., Steinberg, D., and Quehenberger, O., 2000, The binding of oxidized low density lipoprotein to mouse CD36 in mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the hpoprotein, J. Biol. Chem. 275 9163-9169. 

Ramprasad, M.P., Fischer, W., Witztum, J.L., Sambrano, G.R., Quehenberger, O., and Steinberg, D., 1995, The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosiaUn, the mouse homologue of human CD68, Proc. Natl. Acad. Sci. U.S.A. 92 9580-9584. 

Alcouffe, J., Caspar-Bauguil, S., Garcia, V., Salvayre, R., Thomsen, M., and Benoist, H., 1999, Oxidized low density lipoproteins induce apoptosis in PHA-activated peripheral blood mononuclear cells and in the Jurkat T-ceU Une, J Lipid Res.40t 1200-1210. 

Asmis, R., Wintergerst, E.S., 1998, Dehydroascorbic add prevents apoptosis induced by oxidized low-density lipoprotein in human monocyte-derived macrophages, Eur. J. Biochem. 255 147-155. 

Bachem, M.G., Wendelin, D., Schneiderhan, W., Haug, C., Zom, U., Gross, H.J., Schmid-Kotsas, A., and Gmnert, A., 1999, Depending on their concentration oxidized low density lipoproteins stimulate extracellular matrix synthesis or induce apoptosis in human coronary artery smooth muscle cells, Clin Chem Lab Med. 37 319-326. 

Brown, A.J., and Leong, S.L., Dean, R.T., Jessup, W., 1997, 7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque, J. LipidRes. 38 1730-1745. 

Cominacini, L., Pasini, A.F., Garbin, U., DavoU, A., Tosetti, M.L., Campagnola, M., Rigoni, A., Pastorino, A.M., Lo Casdo, V., and Sawamura, T., 2000, Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species, J. Biol. Chem. 275 12633-12638. 

Dimmeler, S., Haendeler, J., GaUe, J., and Zeiher, A.M., 1997, Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-hke proteases. A mechanistic clue to the response to injury hypothesis, Circulation 95 1760-1763. 

Farber, A., KrtzmiUer, T, MorganeUi, PM, Pfeiffer, J, Groveman, D, Wagner, RJ, Cronenwett, J.L., and PoweU, R.J., 1999, A caspase inhibitor decreases oxidized low-density lipoprotein-induced apoptosis in bovine endothelial cells, J. Surg. Res. 85 323-330. 

MabUe, L., Fitoussi, G., Periquet, B., Schmitt, A., Salvayre, R., and Negre-Salvayre, A., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells. Free Radio. Biol. Med. 19 177-187. 

Ohlsson, B.C., Englund, M.C., Karlsson, A.L., Knutsen, E., Erixon, C, Skribeck, H., Liu, Y., Bondjers, G., and Wiklund, O., 1996, Oxidized low density lipoprotein inhibits hpopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1 beta in macrophages, J. Clin. Invest. 98 78-89. 

Okura, Y., Brink, M., Itabe, H., Scheidegger, K.J., Kalangos, A., and Delafontaine, P., 2000, Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques. Circulation 102 2680-2686. 

Siess, W., Zangl, K.J., Essler, M., Bauer, M., Brandi, R., Corrinth, C., Bittman, R., Tigyi, G.,and Aepfelbacher, M., 1999, Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions, Proc. Natl. Acad. Sci. USA 96 6931-6936. 

Steinbrecher, U.P., 1999, Receptors for oxidized low density lipoprotein, Biochim. Biophys. Acta. 1436 279-298. 

Sugawa, M., Ikeda, S., Kushima, Y., Takashima, Y., and Cynshi, O., 1997, Oxidized low density lipoprotein caused CNS neuron ceU death, Brain Res. 761 165-172. 

Tashiro, K., Makita, Y., Strike, T, Shirato, I., Sato, T., Cynshi, O., and Tomino, Y., 1999, Detection of ceU death of cultured mouse mesangial ceUs induced by oxidized low-density lipoprotein. Nephron 82 51-58. 

Auge, N., Nikolova-Karakashian, M., Carpentier, S., Parthasarathy, S, Negre-Salvayre, A., Salvayre, R., Merrill, A.H. Jr., and Levade, T., 1999, Role ofsphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J. Biol. Chem. 274 21533-21538. 

Ab, Antibody BBB, Blood Brain Barrier CNS, Central Nervous System HIV, Human Immunodeficiency Virus HSA, Human Serum Albumin IGF, Insulin Growth Factor I/R, Ischaemia/Reperfusion MW, Molecular Weight OxLDL, Oxidized Low Density Lipoprotein -R, -receptor sCD4, soluble CD4 VEGF, Vascular Endothelial Growth Factor. 

Al-Saikhan, M. S., L. R. Howard, and J. C. Miller Jr. Antioxidant activity and total phenolics in different genotypes of potato (Solarium tuberosum L.). J Etnopharmacol 1995 70(1) 69—74. Abbey, M., M. Noakes, and P. J. Nestel. Dietary supplementation with orange and carrot juice in cigarette smokers lowers oxidation products in copper-oxidized low-density lipoproteins. J Amer Diet Ass 1995 95(6) 671-675. 

Buckley, C, Bund SJ, McTaggart F et al. Oxidized low-density lipoproteins inhibit endothelium-dependent relaxations in isolated large and small rabbit coronary arteries. J. Auton. Pharmacol. 16,... 

Jenkins DJ, Kendall, CW, Vidgen E et al. Effect of soy-based breakfast cereal on blood lipids and oxidized low-density lipoprotein. Metabolism 49, 1496-1500, 2000. 

Pretreatment of neurons by flavonoids (epicatechin and its 3 -D-methylether, kaempferol) strongly inhibits cell death induced by oxidized low-density lipoproteins (ox-LDL) without reduction of ox-LDL uptake or intracellular oxidative stress. Cell protection is selectively correlated to inactivation of JNK, thus suggesting that, irrespective of their H-atom donating activity, flavonoids can selectively attenuate a pro-apoptotic signaling cascade involving MAPKs. 

Schroeter, H. et al., Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (INK), c-Jun and caspase-3, Biochem. J., 358, 547, 2001. 

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