Insulin growth factor-1 IGF

Studies with fenretinide in woman with stage I breast cancer did not show an overall effect of decreasing the risk of contralateral breast cancer. A protective effect could only be observed in premenopausal women, probably due to the modulation of the insulin-like growth factor 1 (IGF-1) by fenretinide in this population. 

Kanagaraj, P, MR Vijayababu, B Ravisankar, J Anbalagan, MM Aruldhas, and J Aranakaran. 2007. Effect of lycopene on insulin-like growth factor-1, IGF binding protein-3, and IGF type-1 receptor in prostate cancer cells. 7 Cancer Res Clin Oncol 133 351-359. 

Li, L, H Ya, F Schumacher, G Casey, and JS Witte. 2003. Relations of serum insulin-like growth factor-1-(IGF-1) and IGF binding protein-3 to risk of prostate cancer(United States). Cancer Causes Control 14 721-726. 

Human growth hormone (hGH) is a polypeptide with 191 amino acids. It is secreted by the pituitary gland. This hormone stimulates the production of insulin-like growth factor-1 (IGF-1) from the liver. Most of the positive effects of hGH are mediated by the IGF-1 system, which also includes specific binding proteins. 

Receptors for EGF, insulin, insulinlike growth factor-1 (IGF-1) Receptors for NGF, TGF... 

Growth hormone (GH, somatotropin) Growth hormone-releasing hormone (GHRH) (+) Somatostatin (-) Liver, muscle, bone, kidney, and others Insulin-like growth factor-1 (IGF-1)... 

The receptor for insulinlike growth factor-1 (IGF-1) is also similar to the insulin receptor in structure and tyrosine kinase activity. Thus, in this case it is likely that the hormones (insulin and IGF-1) and their receptors have each evolved from common ancestral genes by duplication and divergence. 

Insulin-dependent diabetes mellitus (IDDM) is an example of a metabolic disease under active consideration for inducible gene therapy strategies. In this disorder, inflammatory cytokines have been shown to activate apoptosis in pancreatic beta cells. Experimental studies indicate that expression of insulinlike growth factor-1 (IGF-1) can prevent the cytokine-mediated destruction of beta cells of the pancreas (Giannoukakis et al., 2001). Regulated expression of IGF-1 in human pancreatic islets, to preserve beta cell function, may be a useful approach in the treatment of certain types of diabetes (Demeterco and Levine, 2001). 

Insulin-like growth factor-1 (IGF-1) is a peptide, 7649 Da, with structural homology to proinsulin. It binds preferentially to IGF-1 receptors on the surface of target cells. It has a lower affinity for insulin receptors. The receptors for insulin and IGF-1 share some structural and functional homology. IGF-1 is produced in the liver and in other organs in response to growth hormone action. IGF-1 that reenters the circulation is bound to... 

Obal F, Jr., Kapas L, Bodosi B, Krueger JM. Changes in sleep in response to intracerebral injection of insulin-like growth factor-1 (IGF-1) in the rat. Sleep Res Online 1998 1 87-91. 

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