Low-density-lipoprotein receptors

Low-density Lipoprotein Receptor Gene Family Growth Factors... 

HMG-COA-Reductase Inhibitors Low-Density Lipoprotein Receptor Gene Family... 

Very low-density lipoprotein receptor ( VLDLR) and APOE receptor-2 ( APOER2) are two gene family members with redundant functions. They are expressed in neurons of the developing brain and act as cell... 

Low-density Lipoprotein Receptor Gene Family. Table 1 Human diseases of the LDL receptor gene family... 

Nykjaer A, Willnow TE (2002) The low-density lipoprotein receptor gene family a cellular Swiss army knife Trends Cell Biol 12 273-280... 

Douglas SD (2001) Methadone may promote HIV replication study. AIDS Alert 16 120 Dreyer EB, Kaiser PK, Offermann IT, Lipton SA (1990) HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 248 364-367 Dunn S, Vohra RS, Murphy JE, Homer-Vanniasinkam S, Walker JH, Ponnambalam S (2008) The lectin-like oxidized low-density-lipoprotein receptor a pro-inflammatory factor in vascular disease. Biochem J 409 349-355... 

Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ (2000) Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med 6 1380-1387... 

BAUM J A, TENG H, ERDMAN J W Jr, WEIGEL R M, KLEIN B P, PERSKY V W, FREELS S, SURYA P, BAKHIT R M, RAMOS E, SHAY N F and POTTER s M (1998) Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercolesterolemic postmenopausal women. Am J Clin Nutr. 68 (3) 545-51. 

Using human hepatoma-derived cell lines Kong et al. [268] showed that berberine increased mRNA and protein as well as the function of hepatic linear low density lipoprotein receptor (LDLR). It does not stimulate the transcription of LDLR, as the LDLR promoter activity was not increased by this compound. Post-transcriptional regulation appears to be the main working mechanism underlying the effect of this alkaloid on LDLR expression. It was proposed that berberine can be used as a monotherapy to treat hypercholes-terolemic patients [268]. Very recently it was observed [269] that berberine reduces cholesterol and Upid accumulations in plasma as well as Uver. 

Gu L, Okada Y, Clinton SK, et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 1998 2 275-81. 

Ishibashi S, Goldstein JL, Brown MS, Herz J, Bums DK. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 1994 93(5) 1885—1893. 

Hofer F. Members of the low density lipoprotein receptor family mediate cell entry of a minor group common cold virus. Proc Natl Acad Sci USA 1994 91 1839-1842. 

Tserentsoodol, N, Sztein, J, Campos, M, Gordiyenko, NV, Fariss, RN, Lee, JW, Fhesler, SJ, and Rodriguez, IR, 2006b. Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-... 

Heath KE, Gahan M, Whittall RA, Humphries SE. Low-density lipoprotein receptor gene (LDLR) world-wide website in familial hypercholesterolaemia update, new features and mutation analysis. Atherosclerosis 2001 154 243-246. 

Vuorio AF, Ojala JP, Sarna S, Turtola H, Tikkanen MJ, Kontula K. Heterozygous familial hypercholesterolaemia the influence of the mutation type of the low-density-lipoprotein receptor gene and PvuII polymorphism of the normal allele on serum lipid levels and response to lo-vastatin treatment. J Intern Med 1995 237 43-48. 

Heath KE, Gudnason V, Humphries SE, Seed M. The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemia. Atherosclerosis 1999 143 41-54. 

Peltan, I. D., Thomas, A. V., Mikhailenko, I., Strickland, D. K., Hyman, B. T. and von Arnim, C. A. (2006). Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons. Biochem. Biophys. Res. Commun. 349, 24-30. 

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