Oxidation Regulation

Primary signals (effects on hormone-sensitive lipase)  

Secondary signals Malonyl-CoA inhibits carnitine acyltransferase. 

The major hormone-sensitive control point for the mobilization of fat and the p-oxidation pathway is the effect of phosphorylation on the activity of the hormone-sensitive lipase of the adipose tissue. The major direct control point for p oxidation is the inhibition of carnitine acyl- 

The CARNITINE SHUTTLE is used to transport fatty acids into the mitochondria. 

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Owuor, ED. and Kong, AN. 2002. Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol 64 765-770. 

Kuzin, B., Roberts, I., Peunova, N., and Enikolopov, G., 1996, Nitric oxide regulates ceU proliferation during DrosophUa development. Cell 87 639-649. 

Rubbo, H., Radi, R., Trujillo, M., TeUeri, R., Kalyanaraman, B., Bames, S., Kirk, M., and Freeman, B. A., 1994, Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized hpid derivatives, J. Biol. Chem. 269 26066-26075. 

The adsorption of ions on iron oxides regulates the mobility of species in various parts of the ecosystem (biota, soils, rivers, lakes, oceans) and thereby their transport betv een these parts. Examples are the uptake of plant nutrients from soil and the movement of pesticides and other pollutants from soils into aquatic systems. In such environments various ions often compete with each other for adsorption sites. Adsorption is the essential precursor of metal substitution (see Chap. 3), dissolution reactions (see Chap. 12) and many interconversions (see Chap. 14). It also has a role in the synthesis of iron oxides and in crystal growth. In industry, adsorption on iron oxides is of relevance to flotation processes, water pollution control and waste and anticorrosion treatments. 

Gopalakrishna, R., Chen, Z.H. Gundimeda, U. (1994) Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc. natl Acad. Sci. USA, 91, 12233-12237... 

RubboH, Radi R, TmjilloM, Tellari R, KalyanaramanB, Barnes S, KirkM, Freeman, BA. Nitric oxide regulation of superoxide and peroxynitrite-dependent hpid peroxidation. The Journal of Biological Chemistry, 1994, 269, 26066-26075. 

Lieberman, R. L. Rosenzweig, A. C. Biological methane oxidation regulation, biochemistry, and active site structure of particulate methane monooxygenase. Crit. Rev. Biochem. Mol. Biol. 2004, 39(3), 147-164. 

Oxidative Regulation of Proteinase Activities—Protein Inhibitors Balance. 213... 

Swaim, M. W., and Pizzo, S. V., Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors. J. Leukoc. Biol. 43, 365-379 (1998). 

Inflammation is evidenced by increased levels of pro-inflammatory cytokines such as interleukin (IL)-l, IL-6, tumour necrosis factor (TNFa), and C-reactive protein (CRP). The search for the link between these molecular events recorded in the inflammatory process and the derangement of redox equilibria along with the consequence on nitric oxide regulation is the aim of this chapter. 

Van Den ort AL. Yan L, Madara PJ, Cobb JP, Wesley RA, Corriveau CC. Tropea MM and Danner RL, Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils. J Immunol 152(8) 4102-9, 1994. 

Samson, S.L.-A., W.J. Paramchuk and L. Gedamu. The rainbow trout metallothionein-B gene promoter contributions of distal promoter elements to metal and oxidant regulation. Biochim. Biophys. Acta 1517 202-211, 2001. 

Celada, A., and Pastor-Anglada, M. (2000) Nitric oxide regulates nucleoside transport in activated B lymphocytes. Journal of Leukocyte Biology, 67 (3), 345-349. 

Buhrman G, Parker B, Sohn J et al (2005) Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond. Biochemistry 44 5307-5316... 

Ignarro, L. J. (1989). Heme-dependent activation of soluble guanylate cyclase by nitric oxide Regulation of enzyme activity by porphyrins and metalloporphyrins. Semin. Hematol. 26, 63-76. 

Mery, P.-F., Pavoine, C., Belhassen, L., Pecker, F., and Fischmeister, R. (1993). Nitric oxide regulates cardiac Ca current. /. Biol. Chem. 268, 26286-26295. 

Cohen, G. A., Chaudhuri, G., Zinner, M. J., and Ignarro, L. J. (1996). Nitric oxide regulates endothelium-dependent vasodilator responses in the rabbit hindquarters vascular bed in vivo. Am. J. Physiol, in press. 

Mittal, C. K., and Murad, F. (1977a). Review Properties and oxidative regulation of guanylate cyclase. J. Cyclic Nucleotide Res. 3, 381-391. 

Stamler, J. S., Loh, E., Roddy, M.-A., Currie, K. E., and Creager, M. A. (1994). Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89, 2035-2040. 

Brown, G. C. (1995). Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase, FEBS Utt. 369,136-139. 

J. Yang, L. Wu, S. Tashino, S. Onodera, and T. Ikejima, Reactive oxygen species and nitric oxide regulate mitochondria -dependent apoptosis and autophagy in evodiamine-treated human eervix carcinoma HeLa cells. Free Radic. Res., 42 (2008) 492-504. 

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