Lung carcinoma cells

Hellman GM et al. Gene expression profiling of cultured human bronchial epithelial and lung carcinoma cells. Toxicol Sci 2001 61 154-163. 

Wesley UV, Tiwari S, Houghton AN (2004) Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells. Int J Cancer 109(6) 855—866. 

Sharma G Singh RP, Chan DC, Agarwal R. (2003) Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res 23 2649-2655. 

Courage C, Bradder SM, Jones T, Schultze-Mosgau MH, Gescher A (1997) Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine. Int J Cancer 73 763-768... 

Dale IL, Gescher A (1989) Effects of activators of protein kinase C, induding bry-ostatins 1 and 2, on the growth of A549 human lung carcinoma cells. Int J Cancer 43 158-163... 

Wang S, Vrana JA, Bartimole TM, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S (1997) Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2. Mol Pharmacol 52 1000-1009 Wang XY, Repasky E, Liu HT (1999a) Antisense inhibition of protein kinase C alpha reverses the transformed phenotype in human lung carcinoma cells. ]q> Cell Res 250 253-263... 

Fjellbirkeland L, Bjerkvig R, Laerum OD (1998) Non-smaU-cell lung carcinoma cells invade human bronchial mucosa in vitro. In Vitro Cell Dev Biol Anim 34 333-340... 

Shellard SA, Fichtinger-Schepman AMJ, Lazo JS, Hill BT. Evidence of differential cisplatin DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines. Anti-Cancer Drugs 1993 4 491-500. 

O Reilly M, Holmgren L, Shing Y, et al. Angiostatin a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994 79 315-328. 

Toxicology Irritating substance In vitro cytotoxicity on human lung Carcinoma Cell Line Hazard labeling Xn Harmful by inhalation, in contact with skin and if swallowed. May cause sensitization. 

ID50 15 pg/ml [5] (ID = inhibition dose) in vitro cytotoxicity on Human lung Carcinoma Cell Line... 

A high concentration (0.5 mmol/L) of catechol induced a small-scale cytosol-to-membranc transport of protein kinase C, followed by inactivation of the enzyme activity, in cultured LL/2 lung carcinoma cells (Gopalakrishna et al., 1994). 

Gopalakrishna, R., Chen, Z.H. Gundimeda, U. (1994) Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc. natl Acad. Sci. USA, 91, 12233-12237... 

Chien, P.-S., O.-T. Mak, and H.-J. Huang. 2006. Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway. Biochem. Biophys. Res. Commun. 339 562-568. 

The importance of ERK activation by the 5-HT1A receptor is highlighted by the observation that the receptor can stimulate proliferation of T-lymphocytes (13), pancreatic carcinoid tumor cells (52), human small cell lung carcinoma cells (53), and transfected cell lines (25,54). In contrast, endogenous lymphocyte 5-HT1A receptors have been implicated in the inhibition of mitogenesis (55). 

Cattaneo MG, Fesce R, Vicentini LM. Mitogenic effect of serotonin in human small cell lung carcinoma cells via both 5-HT1A and 5-HTm receptors. Eur J Pharmacol 1995 291 209-211. 

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