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Metal substitutions

Since such heavy metals contain many more electrons than the light atoms, H, N, C, O, and S, of the protein, they scatter x-rays more strongly. All diffracted beams would therefore increase in intensity after heavy-metal substitution if all interference were positive. In fact, however, some interference is negative consequently, following heavy-metal substitution, some spots measurably increase in intensity, others decrease, and many show no detectable difference. [Pg.380]

How do we find phase differences between diffracted spots from intensity changes following heavy-metal substitution We first use the intensity differences to deduce the positions of the heavy atoms in the crystal unit cell. Fourier summations of these intensity differences give maps of the vectors between the heavy atoms, the so-called Patterson maps (Figure 18.9). From these vector maps it is relatively easy to deduce the atomic arrangement of the heavy atoms, so long as there are not too many of them. From the positions of the heavy metals in the unit cell, one can calculate the amplitudes and phases of their contribution to the diffracted beams of the protein crystals containing heavy metals. [Pg.380]

Stabilization of a metal-substituted derivative of a minor tautomeric form of the Ugand was reported for the complexes of mixed benzothiazo-line-benzimidazole (388 —> 389) (71ZOB1370 98POL381) and benzothia-zoline-pyridine ligands (390 —> 391/392) (Scheme 144) (77JA7704). [Pg.294]

Nylons are used both in engineering applications and in making fibers. A combination of high impact strength and abrasion resistance makes nylon an excellent metal substitute for bearings and gears. As fiber, nylon is used in a variety of applications, from clothing to tire cord to ropes. [Pg.820]

Carbonic anhydrase an insight into the zinc binding site and into the active cavity through metal substitution. I. Bertini, C. Luchinat and A. Scozzafava, Struct. Bonding (Berlin), 1982, 48, 46-92 (296). [Pg.41]

Alkaline phosphatase, 2,774 mechanism, 6,612 metal substitution, 6,611 structure, 6,611 zinc, 5.1006 6,610 Alkanes... [Pg.80]

Linear Free-Energy Relationships for Metal Substitution... [Pg.201]

FIGURE 8.9. Linear free-energy relationship for the effect of metal substitution on e2 and e3 in staphylococcal nuclease (see text for details). [Pg.202]

See also Enzyme cofactors downhill trajectories for, 196,197 mechanism of catalytic reaction, 190-192 metal substitution, 200-204 potential surfaces for, 192-195,197 rate-limiting step of, 190 reference solution reaction for, 192-195,... [Pg.235]

By the same principle, starting from the appropriate, metal-substituted, organolithium compound, products containing both tin and another metal have been synthesized, e.g.. [Pg.5]

The number of CrB representatives is highly increased by ternary compounds observed in the isothermal sections M -Mo-B and My-W-B just below the transformation T of the CrB-type high-T modifications of MoB and WB into low-T a-MoB or -WB. These ternary compounds therefore represent a stabilization of the high-T form of MoB and WB, respectively, toward lower T by statistical Mo(W)/metal substitution. Transition T (T ) range for WB from 2100°C (W rich) to 2180°C (B... [Pg.191]

Despite the occurrence of binary AIB2 borides (see also Fig. 2), no ternary representatives are known (Mn, Mo)B2 found from isothermal sections is a stabilized high-T phase by conversion to lower T by a statistical ( ) metal-metal substitution. Both MnB2 and M0B2 are high-T compounds stable above 1075°C and 1517°C respectively WB2 is claimed but is either metastable or impurity stabilized. Similar examples are observed with (W, Pd>2B5 (M02B5 type) as well as (Mo, Rh),, (B3 and (W, Ni), B3 (Mo,., 83 type). The phase relations in the B-rich section of the Mo(W)-B binaries, however, are not known precisely. [Pg.207]

Bertini I, Luchinat C, Scozzafava A (1982) Carbonic Anhydrase An Insight into the Zinc Binding Site and into the Active Cavity Through Metal Substitution. 48 45-91 Bertrand P (1991) Application of Electron Transfer Theories to Biological Systems. 75 1-48 Bill E, see Trautwein AX (1991) 78 1-96 Bino A, see Ardon M (1987) 65 1-28 Blanchard M, see Linares C (1977) 33 179-207 Blasse G, see Powell RC (1980) 42 43-96... [Pg.242]

Hoffman BM, Natan MJ, Nocek JM, Wallin SA (1991) Long-Range Electron Transfer Within Metal-Substituted Protein Complexes. 75 85-108 Hoffmann BM, see Ibers JA (1982) 50 1-55... [Pg.247]

Commercially produced metal-substituted chlorophylls such as copper chlorophylls and copper chlorophyllins that can be obtained by chemical modification of natural chlorophylls have better stability, solubility, and tinctorial strength, but they cannot be considered natural food colorants and will be discussed later. [Pg.199]

Bertini, /., Luchinat, C., Scozzafava, A. Carbonic Anhydrase An Insight into the Zinc Binding Site and into the Active Cavity Through Metal Substitution. Vol. 48, pp. 45-91. [Pg.189]

The structural variations observed for [TpRR ]M(N03) (M = Co, Ni, Cu, Zn Cd) reveal that, for a given [Tp1 ] ligand, the preference for bidentate coordination increases across the series Zn < Co Cu, Ni, and Cd. Significantly, these structural preferences of the nitrate ligand correlate with the activity of the metal-substituted enzymes Zinc, the metal with the greatest tendency to exhibit unidentate coordination of the nitrate ligand, is the most active, while nickel, copper, and... [Pg.364]

This suggestion is not necessarily intended to imply that the bicarbonate intermediate of the carbonic anhydrase cycle must exhibit unidentate coordination in the ground state. Rather, it is intended to imply that a unidentate species should be readily accessible. Moreover, it is not intended to suggest that this factor alone is responsible for influencing the activity of metal-substituted carbonic anhydrases,... [Pg.393]


See other pages where Metal substitutions is mentioned: [Pg.225]    [Pg.396]    [Pg.17]    [Pg.119]    [Pg.368]    [Pg.201]    [Pg.203]    [Pg.205]    [Pg.118]    [Pg.168]    [Pg.191]    [Pg.192]    [Pg.193]    [Pg.124]    [Pg.214]    [Pg.254]    [Pg.100]    [Pg.361]    [Pg.363]    [Pg.366]    [Pg.369]    [Pg.262]    [Pg.1165]    [Pg.1262]    [Pg.195]    [Pg.177]   
See also in sourсe #XX -- [ Pg.22 ]

See also in sourсe #XX -- [ Pg.501 ]




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1- Substituted 1,2,3-triazoles, metallation

1- Substituted 1,2,3-triazoles, metallation oxidation

2-Cyclohexenone, 5-substituted via arene-metal complexes

Acetonates substituted, alkali metal

Alkaline phosphatase metal substitution

Alkyne-Substituted Transition Metal

Alkyne-Substituted Transition Metal Clusters

Alkyne-substituted mixed-metal clusters

Allylic substitution metal-mediated reactions

Allylic substitutions metal-catalyzed

Aromatic Substitution by Metal Catalysis or Other Complex Mechanisms

Aromatic substitution by metal

Aromatic substitution by metal catalysis

Aromatic substitution by metalation

Aromatic substitution metal-catalyzed

Base metal benzenes, substituted, from

Blue copper proteins metal substitution

Carbonic anhydrase metal-substituted

Carbonyl substituted metal complexes

Carbonyls, metal photochemical substitution

Carboxypeptidase metal substitution

Cationic metal carbonyls ligand substitution reactions

Cobalt, mixed-metal clusters substitution

Copper-zinc superoxide dismutase metal substitutions

Cytochrome metal substitution

D-electron transition metal substituted

Deprotonative metalation substituted benzenes

Disilanes transition-metal substituted

Effects of metal ion substitutions

Electrophilic Substitution Reactions on Metalated Aromatic Compounds

Electrophilic Substitution in Metal Complexes

Electrophilic aromatic substitution metalation

Electrophilic substitution metal-catalyzed intramolecular reaction

Electrophilic substitutions of allyl-metal compounds

Electrophilic substitutions which involve metallic derivatives

Formation Involving Unsubstituted Metal Ions Multidentate Ligand Substitution

From metal cyanides substitution reactions

From substituted metal carbonyls

General mechanisms for substitution at a solvated metal ion

Group 5 metal halide clusters ligand substitution

Hematite metal substitution

Hexaaluminate metal-substituted

Hydrides, metal photochemical substitution

Isolobal metal fragment substitution

Labile transition-metal ions, ligand substitution

Ligand Substitution Reactions in Carbonyl Metal Clusters

Ligand Substitution in Transition Metal ir-Complexes

Ligand Substitution in Transition Metal w-Complexes

Ligand Substitution on Labile Transition-Metal Ions

Ligand substitution reactions transition metal complexes

Ligand substitution, metals/metal complexes

Magnetite metal substituted

Main group-transition metal cluster substitution reactions

Mechanisms of Substitution Reactions Metal Complexes

Mesoporous metal-substituted

Metal Substituted Carbodiimides

Metal Substituted Organogermanium Sulfides, Selenides and Tellurides

Metal Substituted Organolead Sulfides, Selenides and Tellurides

Metal Substituted Triorganotin Halides

Metal Substitutions of (a-Haloalkyl)boronic Esters

Metal carbonyl substitution

Metal carbonyls ligand substitution reactions

Metal carbonyls substitution mechanisms

Metal carbonyls substitution reactions

Metal carbonyls, substituted

Metal catalysis nucleophilic substitution

Metal complexes ligand substitution mechanisms

Metal complexes square planar, substitution

Metal complexes—continued substitution reactions

Metal functionally substituted

Metal groups 3-hetero-substituted compounds

Metal groups conjugate substitution

Metal groups nucleophilic substitution

Metal halides, substitutions, 2- ethyl

Metal insertion allylic substitution

Metal insertion substitution reactions

Metal ion substitution

Metal ions ligand substitution

Metal substituted

Metal substituted

Metal substitution and spectroscopy

Metal substitution and spectroscopy binding constants

Metal substitution and spectroscopy first transition series

Metal substitution and spectroscopy group 13 metals

Metal substitution and spectroscopy lanthanides

Metal substitution and spectroscopy structural aspects

Metal substitution, effect

Metal substitution, effect aggregation

Metal substitutional

Metal substitutional

Metal-Substituted Mesoporous Silica Molecular Sieves

Metal-carbene complexes alkoxy substituted

Metal-carbene complexes amino substituted

Metal-carbene complexes ligand substitution reactions

Metal-carbonyl complexes, substitution

Metal-carbonyl complexes, substitution reactions

Metal-free allylic substitution

Metal-halogen exchange substitution reactions

Metal-peptides substitution reactions

Metal-substituted Hexaaluminate Catalysts

Metal-substituted Molecular Sieves as Catalysts for Allylic and Benzylic Oxidations

Metal-substituted alkylidynes

Metal-substituted aluminum phosphate

Metal-substituted chlorophylls

Metal-substituted haemoproteins

Metal-substituted heme protein

Metal-substituted zinc proteins

Metalation and Nucleophilic Substitution

Metallation of Hetero-Substituted Benzene and Naphthalene with BuLi TMEDA in Hexane

Metallic substitutions

Metallic substitutions

Mixed-metal clusters ligand substitution

Nitriles metal-catalyzed substitution

Nuclear magnetic resonance metal substitution

Nucleophilic Substitution, Metallation, and Halogen-Metal Exchange

Nucleophilic aromatic substitution metal-catalyzed

Nucleophilic substitution metallation reactions

Other Transition Metal-substituted Molecular Sieves

Oxidation with metal substituted molecular sieve

Peptide-metal complexes substitution reactions

Peripheral metalation, oxygen-substituted

Photochemical substitution reactions transition metal complexes

Photochemistry of Substituted Metal Carbonyls

Polyoxometallates transition metal substitution

Pre-lab 4.1 Substitution Properties of Metal Ion Complexes in

Pyridines, 3-substituted, directed metalation

Reactions metal-free allylic substitution

Reactions metallation/ electrophilic substitution

Reactions of Metal Substituted Carbodiimides

Silsesquioxane transition metal substitution

Sodium alkyl thiolates, reaction with halogen substituted metal complexes

Staphylococcal nuclease metal substitution

Structurally colored substituted with metallic

Substituted toluenes, benzylic metallation

Substitution Processes in Dimeric Metal Complexes

Substitution Products of the Group VIB Metal Carbonyls

Substitution Reactions of Inert-Metal Complexes— oordination Numbers 4 and

Substitution Reactions of Inert-Metal Complexes— oordination Numbers 6 and Above Chromium House ntroduction

Substitution Reactions of Inert-Metal Complexes— oordination Numbers 6 and Above Cobalt Hay Aquation

Substitution Reactions of Solvated Metal

Substitution Reactions of Solvated Metal Ions

Substitution Studies of Second- and Third-Row Transition Metal Oxo

Substitution in the Presence of Metal Salts

Substitution of Ligands at the Transition Metal

Substitution on Complexes of Alkali and Alkaline Earth Metal Ions

Substitution on Complexes of Oxo Metal Ions

Substitution on Complexes of the Trivalent Main Group Metal Ions

Substitution on Trivalent Metal Ions

Substitution reaction, alkali metal

Substitution reactions metal alkene complexes from

Substitution reactions metal-mediated

Substitution reactions of metal carbonyls

Substitution reactions on metal complexes

Substitution reactions transition metal-catalyzed vinylic

Substitution reactions without metal-ligand bond cleavage

Substitution reactions, transition metal complexes

Substitution synthesis using transition metal

Substitution transition metal catalysis

Substitution, electrophilic halogenation, metal

Substitutional Metal Borides

Synthesis of Metal Substituted Carbodiimides

TMSP (transition metal substituted

Tetravalent metals, substitution

Thermodynamic Tuning of Single Phase Hydrides by Substitution on the Metal Site

Thiophene, metallation substitution chemistry

Transition Metal-Catalyzed Aromatic Substitution Reactions

Transition Metal-Substituted Calcium Orthophosphates

Transition metal catalysis aromatic substitution

Transition metal catalysis nucleophilic substitution

Transition metal clusters substitution reactions

Transition metal ions ligand substitution

Transition metal ions ligand substitution reactions

Transition metal substituted

Transition metal substituted polyoxometalate

Transition metal substituted polyoxometalate 4 with

Transition metal substituted polyoxometalates

Transition metal substituted polyoxometalates TMSP)

Transition metal substituted polyoxometallates

Transition metals catalyzed vinylic substitution

Transition metals redox-catalyzed substitution

Transition metals substitution

Transition-Metal-Catalyzed Substitution Reactions

Transition-metal-catalyzed reactions allylic substitution

Transition-metal-substituted POMs

Transition-metal-substituted oligosilanes

Transition-metal-substituted polysilanes

Using acetylenic reactivity nucleophilic substitution with metal acetylides and related reactions

Variation of Substitution Rates with Metal Ion

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