Apoptosis p53-dependent

Hastak K, Agarwal MK, Mukhtar H, Agarwal ML. 2005. Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin-3-gallate. FASEB J 19 789-791. 

Tang HY, Shih A, Cao HJ, Davis FB, Davis PJ, Lin HY. 2006. Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Mol Cancer Ther 5 2034-2042. 

M. E. McCurrach, T. M. Connor, C. M. Knudson, S. J. Korsmeyer, and S. W. Lowe, bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Nad AcadSci, USA, 94 (6), 2345-2349, 1997. 

T. Norimura, S. Nomoto, M. Katsuki, Y. Gondo, and S. Kondo. p53-dependent apoptosis suppresses radiation-mduced teratogenesis [see comments]. Nature Med, 2 (5), 577-580, 1996. 

Lowe, S., Ruley, H., Jacks, T. andHousman, D. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 957-967. 

Kojima K, Konopleva M, Samudio IJ et al (2005) MDM2 antagonists induce p53-dependent apoptosis in AML implications for leukemia therapy. Blood 106 3150-3159... 

Inhibits proliferation of tumors, cell lines or fibroblasis transformed by H-ras or trk oncogenes. Inhibits thymidylate synthetase and depletes dTTP it forms nucleotides that can be incorporated into RNA and DNA and induces p53-dependent apoptosis. 

Yan, Y. et al.. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation, J. Biol Chem., 272, 15220, 1997. 

Schuler M, Green DR. Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 2001 29(Pt 6) 684-688. 

Ihtie RA, Attardi LD. Petp-ettating p53-dependent apoptosis. Cell Cycle 2004 3(3). 

Ihrie RA, Reczek E, Horner JS et al. Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol 2003 13(22) 1985-1990. 

Koster R, Timmer-Bosscha H, Bischoff R, Gietema JA, de Jong S. Dismption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway. Cell Death Dis. 2011 2 el48. doi 10.1038/cddis.2011.33. 

Tuhvatulin, A.I., et al. Non-thermal Plasma Causes p53-Dependent Apoptosis in Human Colon Carcinoma Cells. Acta Naturae 4(3), 82-87 (2012)... 

Roos et al. demonstrated the induction of p53-dependent apoptosis through p53 transcriptional activation in mES cells. Upon induction of CX-methylguanine by treatment with N-methyl-N-nitro-N-nitrosoguanidine, apoptosis seemed activated via the Fas death pathway as the Fas receptor, which is transcriptionally regulated by p53, was upregulated and caspase-3 and -7 were activated. The lack of cytochrome-C release and the increase of the Bcl-2/Bax fraction, indicative of pa-otection against mitochondrial-mediated apoptosis, demonstrate the inactivity of this latter apwptotic p>athway (Roos et al. 2007). 

Yamauchi R, Sasaki K, Yoshida K (2009) Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549. Toxicol In Vitro 23 834—839... 

Choi MS, Yuk DY, Oh JH, Jung HY, Han SB, Moon DC, Hong JT (2008) Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis. Anticancer Res 28 3777-3784... 

Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y. p53AIPl, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 2000 102 849-862. 

Suzuki H, Tomida A, Tsuruo T. Dephosphorylated hypoxia-inducible factor lot as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 2001 20 5779-5788. Goldberg M, Zhang HL, Steinberg SE Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes. J Clin Invest 1997 99 55-61. 

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