Biomimetic scaffold

Mercuri J, Gill S, Simionescu D (2011) Novel tissue derived biomimetic scaffold for regenerating the human nucleus pulposus. J Biomed Mater Res A 96(2) 422 135... 

Creating Electrospun Nanofiber-Based Biomimetic Scaffolds for Bone Regeneration... 

Comparison of Nanofiber-Based Biomimetic Scaffolds with Other Types... 

Creating Electrospun Nanoflber-Based Biomimetic Scaffolds... 

Li X et al (2008) Coating electrospun poly(epsilon-caprolactone) fibers with gelatin and calcium phosphate and their use as biomimetic scaffolds for bone tissue engineering. Langmuir 24(24) 14145-14150... 

Yan LP, Wang YJ, Wu G et al (2010) Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications. J Biomed Mater Res 95A 465 75... 

Inspired by the hierarchical structures that enable bone function, Deng et al. recently developed a mechanically competent 3D scaffold mimicking the bone marrow cavity and the lamellar structure of bone by orienting electrospun polyphosphazene-polyester blend nanofibers in a concentric manner with an open central cavity (Figure 11.9b and c) [66]. The 3D biomimetic scaffold exhibited mechanical characteristic similar to native bone. Compressive modulus of the scaffold was found to be within the range of human trabecular bone. When tuned to have desired properties, the concentric open macrostructures of nanofibers that structurally and mechanically mimic the native bone can be a potential scaffold design for accelerated bone healing. 

FIGURE 11.9 (a) Polyphosphazene nanofibrous scaffolds (b) SEM image illustrating the morphologies of cell-seeded 3D biomimetic scaffolds after... 

The feasibility of incorporating nonstandard amino acids into peptides/ proteins offers valuable options to modulate the functionality and reactivity of the produced molecular structures. Novel amino acids can be introduced in either a residue-specific or site-specific fashion. Integrating these engineered peptides into biomimetic scaffolds facilitates the construction of biomaterials with tunable chemical and mechanical properties. 

Using appropriate anhydrous processing techniques, which prevent the hydrolysis of the active ester end groups, then allows for the manufacture of biomimetic scaffolds for tissue engineering.Further commonly used processing techniques for the overall class of poly(a-hydroxy esters) include electro-spinning for the manufacture of fibers and emulsion/solvent... 

Tissue engineering scaffold for DNA delivery by cationic polymers. Biomimetic scaffolds can be encapsulated with growth factors and MSCs are seeded onto their surface [top]. Polymeric release bottom left) consists in the entrapment of the complexes between cationic polymers and DNA within the biomaterial for release into the environment. Conversely, substrate-mediated delivery bottom right), also termed reverse transfection delivery, employs the immobilization of complexes to the biomaterial. MSCs can internalize the complexes either directiy or by degrading the linkage between the biomaterial and DNA complexes. 

Bock N, Riminucci A, Dionigi C, Russo A, Tampieri A, Landi E, et al. A novel route in bone tissue engineering magnetic biomimetic scaffolds. Acta Biomater 2010 6 786-96. 

Biomimetic scaffolds for bone engineering should be osteoconductive, osteoinductive, biocompatible, and biodegradable. Osteoconductivity refers... 

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