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Disc degeneration

Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration... [Pg.201]

Keywords Biomaterials Biopolymers Intervertebral disc Intervertebral disc degeneration Nucleus pulposus Tissue engineering... [Pg.201]

T able 2 Summary of the matrix metalloproteinases involved in intervertebral disc degeneration [26,41]... [Pg.207]

As seen above, implanting cells without scaffold support or scaffolds without cells may not prove efficacious. NP allograft studies in a lapine disc degeneration model indicate that injection of NP cells alone does not mitigate degeneration as effectively as implanting NP allografts, and can result in the formation of fibrotic... [Pg.222]

Miller JA, Schmatz C, Schultz AB (1988) Lumbar disc degeneration correlation with age, sex, and spine level in 600 autopsy specimens. Spine (Phila Pa 1976) 13(2) 173—178... [Pg.225]

Pye SR et al (2004) Radiographic features of lumbar disc degeneration and self-reported back pain. J Rheumatol 31(4) 753-758... [Pg.225]

Le Maitre CL et al (2007) Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans 35(Pt 4) 652-655... [Pg.226]

Rutges JP et al (2008) Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels. J Pathol 214(4) 523-530... [Pg.226]

Walker MH, Anderson DG (2004) Molecular basis of intervertebral disc degeneration. Spine J 4(6 Suppl) 158S-166S... [Pg.226]

Goupille P et al (1998) Matrix metalloproteinases the clue to intervertebral disc degeneration Spine (Phila Pa 1976) 23( 14) 1612—1626... [Pg.227]

Kaneyama S et al (2008) Fas ligand expression on human nucleus pulposus cells decreases with disc degeneration processes. J Orthop Sci 13(2) 130—135... [Pg.228]

Sobajima S et al (2008) Feasibility of a stem cell therapy for intervertebral disc degeneration. Spine J 8(6) 888-896... [Pg.229]

Abbushi A et al (2008) Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degeneration. Spine 33(14) 1527-1532... [Pg.230]

Nomura T et al (2001) Nucleus pulposus allograft retards intervertebral disc degeneration. Clin Orthop Relat Res 389 94-101... [Pg.232]

Nuckley DJ et al (2008) Intervertebral disc degeneration in a naturally occurring primate model radiographic and biomechanical evidence. J Orthop Res 26(9) 1283-1288... [Pg.232]

Masuda K et al (2005) A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine 30( 1) 5—14... [Pg.232]

Sobajima S et al (2005) A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology. Spine 30(l) 15-24... [Pg.232]

Singh K, Masuda K, An H (2008) Animal models for human disc degeneration. In Yue J, Bertagnoli R, McAfee P, An H (eds) Motion preservation surgery of the spine advanced techniques and controversies. Elsevier, Philadelphia, pp 639-648... [Pg.232]

Kroeber MW et al (2002) New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration. [Pg.232]

Kim KS et al (2005) Disc degeneration in the rabbit a biochemical and radiological comparison between four disc injury models. Spine (Phila Pa 1976) 30(l) 33-37... [Pg.232]

Hoogendoom RJ et al (2007) Experimental intervertebral disc degeneration induced by chondroitinase ABC in the goat. Spine (Phila Pa 1976) 32(17) 1816-1825... [Pg.232]

Low back pain is the leading cause of job-related disability in the United States and second only to headache as the most common neurologic complaint [11]. The causes are many, but degeneration of the spine and intervertebral discs are frequently blamed. Conventional scientific consensus says intervertebral disc degeneration and other spinal abnormalities are largely mechanical, but recent evidence has implicated genetic and biochemical... [Pg.86]

Jim JJ, Noponen-Hietala N, Cheung KM, et al. The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine 2005 30(24) 2735 2. [Pg.93]

In terms of medical applications, DSC has been used to examine intervertebral disc degeneration in humans . The results suggested that definitive differences exist between the stages of disc degeneration in calorimetric measures. [Pg.169]

Le Maitre C, Freemont A, Hoyland J. Human disc degeneration is associated with increased MMP 7 expression. Biotech Histochem 2006 81 125-131. [Pg.148]

Le Maitre CL, Freemont AJ, Hoyland JA. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005 7 R732-R745. [Pg.149]

Kawaguchi Y, Osada R, Kanamori M, Ishihara H, Ohmori K, Matsui H, Kimura T. Association between an aggrecan gene polymorphism and lumbar disc degeneration. Spine 1999 24 2456-2460. [Pg.149]

Feng H, Danfelter M, Stromqvist B, Heinegard D. Extracellular matrix in disc degeneration. J Bone Joint Surg 2006 88A(Suppl 2) 25-29. [Pg.152]

Cs-Szabo G, Ragasa-San Juan D, Turumella V, Masuda K, Thonar EJ, An HS. Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine 2002 27 2212-2219. [Pg.153]

Bertram H, Steck E, Zimmermann G, Chen BH, Carstens C, Nerlich A, Richter W. Accelerated intervertebral disc degeneration in scoliosis versus physiological ageing develops against a background of enhanced anabolic gene expression. Biochem Biophys Res Commun 2006 342 963-972. [Pg.153]

M. Alini, P. Roughley, J. Antoniou, T. Stoll, M. Aebi, A biological approach to treating disc degeneration na for today, but maybe for tomorrow, Eur. Spine J. 11 (2002) S215-S220. [Pg.113]

Recent Advances in Regenerative Approaches to Intervertebral Disc Degeneration... [Pg.427]

Wang et al [35] have been compared the regenerative potentials of the AF, NF and CEF-derived stem cells with that of the classic BMSCs in a rabbit disc degeneration model. They found cartilage endplate-derived stem cells (CESCs) with superior capacity compared with the annulus fibrosus-derived stem cells (AFSCs), nucleus pulposus-derived stem cells (NFSCs), and BM-MSCs (p<0.05). This information provides good direction for the application of disc-derived stem cells. [Pg.432]

See other pages where Disc degeneration is mentioned: [Pg.202]    [Pg.202]    [Pg.207]    [Pg.223]    [Pg.119]    [Pg.86]    [Pg.87]    [Pg.119]    [Pg.688]    [Pg.105]    [Pg.234]   
See also in sourсe #XX -- [ Pg.134 , Pg.137 , Pg.140 , Pg.144 , Pg.146 ]



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