Proteoglycans synthesis

Aguiar DJ, Johnson SL, Oegema TR (1999) Notochordal cells interact with nucleus pulposus cells regulation of proteoglycan synthesis. Exp Cell Res 246( 1) 129—137... 

R. Wu, J. Yankaskas, E. Cheng, M. R. Knowles, and R. Boucher. Growth and differentiation of human nasal epithelial cells in culture. Serum-free, hormone-supplemented medium and proteoglycan synthesis. Am Rev Respir Dis 132 311— 320 (1985). 

Lubberts E, Joosten LA, van de Loo FA, van den Gersselaar LA, van den Berg WB Reduction of interleukin-17-induced inhibihon of chondrocyte proteoglycan synthesis in intact murine articular carhlage by interleukin-4. Arthritis Rheum 2000 43 1300-1306. 

Collier S, Ghosh R Comparison of the effects of NSAIDs on proteoglycan synthesis by articular cartilage explant and chondrocyte monolayer cultures. Biochem Pharmacol. 1991 41 1375-1384. 

Malemud CJ, Stevenson S, Mehraban F et al. (1994) The proteoglycan synthesis repertoire of rabbit chondrocytes maintained in type II collagen gels. Osteoarthritis and Cartilage 2 29-42... 

The effect of serum concentrations on proteoglycan synthesis has been studied by McQuillan et al. (1986), serum-free conditions with CR-ITS as a substitute were administered by Steinmeyer et al. (1998), and the effect of different concentrations of DMSO and glycerol, of importance for cryopreservation, has been examined on human fetal hip cartilage by Yang and Zhang (1991). 

In other studies, NSAIDs, such as carprofen and benoxaprofen, have been reported to increase proteoglycan synthesis in cartilage explants and chondrocytes (Mcllwraith 1996, Palmoski Brandt 1983). Obviously, more work is needed to determine the effects of NSAIDs on normal and arthritic joints. 

Owens J G, Kamerling S G, Stanton S R et al 1996 Effects of pretreatment with ketoprofen and phenylbutazone on experimentally induces synovitis in horses. American Journal of Veterinary Research 57 866-874 Palmoski M J, Brandt K D 1983 Benoxaprofen stimulates proteoglycan synthesis in normal canine knee cartilage in vitro Arthritis and Rheumatism 26 771-774 Pasargiklian M, Bianco S 1986 Perspectives in the treatment of reversible ainway obstruction. Respiration 50(suppl 2) 131-136... 

D. J. Carey Biological functions of proteoglycans Use of specific inhibitors of proteoglycan synthesis. Molecular and Cellular Biochemistry 104 21 (1991). 

Interest in chondroitin and glucosamine was spurred initially by anecdotal reports of benefit in animals and humans, and by the fact that these substances stimulate proteoglycan synthesis from articular cartilage in vitro and have an excellent safety profile. Enthusiasm for these agents continues. ... 

T14. Tsuji, M., Kato, Y., Nomura, Y., Kinoshita, M., Kumahara, Y., and Suzuki, F., Effect of multiplication-stimulating activity (MSA) on the cyclic AMP level and proteoglycan synthesis in cultured chondrocytes. Acta Endocrinol. (Copenhagen) 104, 117-122 (1983). 

Microglia Osteoclast activation Decreased proteoglycan synthesis Fibroblast proliferation Muscle proteolysis Endothelial cell activation... 

Fig. 16.1 Ma nganese-deficient calf with rolling tongue as a result of a nervous tremor and with enlargements of the foreleg joints because of disturbed proteoglycan synthesis.

Synthesis of acid sugars for proteoglycan synthesis and formation of glucuronides... 

Yeo TK, Brown L, Dvorak HF. Alterations in proteoglycan synthesis common to healing wounds and tumors. Am J Pathol 1991 138 1437-1450. 

This decrease in heparan sulfate proteoglycan synthesis may account for... 

Bollineni JS, Alluru I, Reddi AS. Heparan sulfate proteoglycan synthesis and its expression are decreased in the retina of diabetic rats. Curr Eye Res 1997 16 127-130. 

Rada JA, McFarland AL, Cornuet PK, Hassell JR. Proteoglycan synthesis by scleral chondrocytes is modulated by a vision dependent mechanism. Cnrr Eye Res 1992 11 767-782. 

Nickla DL, Wildsoet C, Wallman J. Compensation for spectacle lenses involves changes in proteoglycan synthesis in both the sclera and choroid. Curr Eye Res 1997 16 320-326. 

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