Nocardia/nocardiae

L-lysine (N-acetyl-L-lysine) Brevibacterium ketoglutamicum Nocardia sp. hom 75... 

Rifamycins. The rifamycins were first isolated from a broth of Nocardia mediterranei (the producing organism was originally identified as Streptomyces mediterranei). The rifamycins, the stmctures of which are shown in Figure 3, were originally designated as rifomycins. Only rifamycin B (22), which accounts for 10—15% of the cmde complex, can be isolated easily as a stable, crystalline compound (6,89,90). 

Kanglemycin. Kanglemycia (74) (Fig. 8) is isolated from the fermentation broth filtrate of Nocardia mediterranei var kanglensis (1747-64) and its stmcture determiaed by x-ray crystallographic studies. The antibiotic is active against gram-positive bacteria (28). 

A51568A (A/-demethyl-vancomycin), B Nocardia orientalis N RRL 15232 1982 Lilly 39,40... 

Carbamate hydrolysis is frequendy observed as the initial reaction for pesticides having carbamate bonds, such as aldicarb, carbofuran, carbaryl, and benomyl (eq. 12) (19). Numerous genera of carbamate-hydroly2ing bacteria have been identified, including Pseudomonas, Jhihrobacter, Bacillus, Nocardia, Achromobacter, Flavobacterium, Streptomyces, Alcaligenes, A spirillum, Micrococcus, and Bhodococcus. 

Methanobacterium thermoautotrophicum Methanosarcina barkeri Micromonospora purpurea Nocardia gardneri... 

Nocardia rugosa Propionibacterium arabinosum Propionibacteriumfreudenreichii Propionibacterium pentosaceum Propionibacterium peterssoni Propionibacterium shermanii Propionibacterium technicum Propionibacterium vannielli Protaminobacter ruber Pseudomonas denitrificans Bhi bium meliloti Bhodopseudomonas capsulata Bhodopseudomonas spheroides Strigomonas oncopelti Streptomyces aureofaciens Streptomyces griseus Streptomyces olivaceus... 

Streptomyces ribosidificus ATCC 31051, Streptomyces hygroscopicus PERM P-3159, Streptomyces hygroscopicus 24367 Streptomyces ribosidificus ATCC 31051 Streptomyces ribosidficus ATCC 31051 yActinomadurayumaense NRRL 12515, Nocardia sp. X 14868 ATCC 31585... 

The iron-free ligand, deferrioxamine E, is identical with nocard-amine,a metabolite from a Nocardia species, which was earlier erroneously formulated as 16 and then 17. ... 

Vancomycin, ristocetin A and teicoplanin are produced as fermentation products of Streptomyces orientalis, Nocardia lurida and Actinoplanes teichomyceticus, respectively. All three of these related compounds consist of an aglycone basket made up of fused macrocyclic rings and pendant carbohydrate moieties (Fig. 2-1). The macrocycles contain both ether and peptide linkages. The aglycones of vancomycin and teicoplanin contain two chloro-substituted aromatic rings, while the analogous portion of ristocetin A contains no chloro substituents. 

Allenes are compounds with adjacent carbon-carbon double bonds. Many allenes are chiral, even though they don t contain chirality centers. Mycomycin, for example, a naturally occurring antibiotic isolated from the bacterium Nocardia acidophilus, is chiral and has = -130. Explain why mycomycin is chiral. Making a molecular model should be helpful. 

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