Micromonospora purpurea

Methanobacterium thermoautotrophicum Methanosarcina barkeri Micromonospora purpurea Nocardia gardneri... 

Gentamicin Micromonospora purpurea Broad spectrum Protein synthesis... 

Antibiotics, e.g. Benzylpenicillin Gentamicin Nystatin Penicillin notatum, P. chrysogenum Micromonospora purpurea Streptomyces noursei Antibacterial drug Antibacterial drug Antifungal drug... 

Other medicinally useful aminoglycoside antibiotics are based on the aminocyclitol 2-deoxystrepta-mine, e.g. gentamicin Ci from Micromonospora purpurea. Although streptamine and 2-deoxystrepta-mine are actually cyclohexane derivatives, they are both of carbohydrate origin and derived naturally from glucose. 

Streptomyces tenebrarius). Gentamicin is isolated from Micromonospora purpurea, and it consists of a mixture of approximately equal amounts of three compounds gentamicines C[, C[j, and Cj. Amikacin and netilmicin are semisynthetic drugs. Amikacin is a chemical modification of kanamycin. Netilmicin is a semisynthetic derivative of schizomycin, which is isolated from Micromonospora inyoensis. 

From fermentation solutions of Micromonospora purpurea Micromonospora echinospora. 

Streptomyces nodosus Streptomyces verticillus Cephalosporium sp. Saccharopolyspora erythraea Micromonospora purpurea Aspergillus terreus Streptomyces fradiae Pencillium chrysogenum Streptomyces ambofaciens Streptomyces aureofaciens Streptomyces orientalis... 

When L-[methyl-14C]methionine was added to a growing culture of Micromonospora purpurea, a high incorporation of radioactivity into gentamicins was observed.68 As expected, the radioactivity incorporated into gentamicins increased with the number of C-methyl and N-methyl groups in the molecule (Cla 3, C218, and Cj 60% of the total incorporation). 

Studies on the biosynthetic relationships of the various gentamicins were conducted with mutants blocked in regard to formation of gentamicin. A mutant of Micromonospora purpurea blocked in synthesis of gentamicin produced71 the pseudodisaccharide paro-mamine (see Scheme 16). 

Micromonospora purpurea Gentamicin sulfate Micromonospora sagamiensis Micro nomicin Penicillium bacterium Penicillin 0 Penicillium patulum Griseofulvin Pseudomonas bacterium Salicylic acid Semliki Forest arborvirus Interferon Septomyxa affinis Fluprednisolone Methylprednisolone Sporidiobolus ruinenli Ubidecarenone Streptococcus fecalis Floxuridine... 

Gentamicin is a mixture of several antibiotic components produced by fermentation of Micromonospora purpurea and other related soil microorganisms (hence its name is spelled with an i instead of a y ). 

Michaelis-Menten kinetics 156 Michaelis-Menten equation 36 microencapsulation 179 microinjection 252 Micromonospora purpurea 13 microvilli 177 milbemycin 13 mithramycin 13, 18 mitomycin C 13 moenomycin 13 molecular farming 30 Monascus 25 monensin 13... 

In the same way, horn Micromonospora purpurea mutants, gentamicin analogues are synthesised with variations in 2- and 5-positions ... 

C20H36N4O7 444.527 Aminoglycoside antibiotic. Isol. from Micromonospora purpurea. Active against gram-positive and -negative bacteria and mycobacteria. Sol. H2O fairly sol. MeOH, EtOH poorly sol. MejCO, hexane. [ ] +144 (H2O). 

C18H36N4O10 468.503 Isol. from Micromonospora purpurea and Micromonospora echinospora. Aminoglycoside antibiotic. Solid. Sol. H2O poorly sol. EtOH, hexane. [ ]d +141 (c, 0.44 in H2O). Log P -6.66 (uncertain value) (calc). 

C20H40N4O8 464.558 Prod, by Micromonospora purpurea nigrescens. Sol. H2O fairly sol. MeOH poorly sol. butanol, hexane. 

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