Minocycline-rifampin

M marinum Granulomatous cutaneous disease Amikacin, clarithromycin, ethambutol, doxycycline, minocycline, rifampin, trimethoprim-sulfamethoxazole... 

Minocycline + rifampin (or streptomycin) Brucella canis (dogs)... 

However, the majority of the antimicrobial-treated CVCs available on the market (Table 12.4) are obtained by adsorption of the drug onto the catheter surface, since this method is facile, inexpensive, and potentially apphcable for a wide range of drugs. Only in the two types of CVCs treated with silver, the antimicrobial agents are impregnated in the polymer bulk. Often, to improve drug affinity for the device surface, cationic surfactants are used, such as tridodecylmethylammonium chloride (TDMAC) and benzalkonium chloride employed for the adsorption of minocycline/rifampin and heparin, respectively. 

The most experimented antimicrobial dmgs for intravascular devices are chlorhex-idine/silver sulfadiazine (CH/SS) and minocycline-rifampin (MR). From a historical point of view, CVCs coated with one of these two drugs are the first medicated catheters approved for clinical trials. 

To provide protection against P. aeruginosa, Raad et P developed novel antimicrobial-coated PU CVCs based on a combination of chloihexidine and minocycline-rifampin (CH-MR). CH-MR coating was shown to provide better protection against methicillin-resistant S. aureus, P. aeruginosa, and Candida spp. and a prolonged antimicrobial durability than CH/SS and MR coatings. ... 

Jamal MA, Rosenblatt JS, Hachem RY, et al. Prevention of biofllm colonization by Gram-negative bacteria on minocycline-rifampin-impregnated catheters sequentially coated with chlorhexidine. Antimicrob Agents Chemother February 2014 58(2) 1179-82. 

Coated catheters CHSS or minocycline/rifampin for dwelling times >5 days if lack of control despite basic practices Lack of control despite basic practices No recommendation... 

A combination of amphotericin B, miconazole (16), and rifampin (17) was used to successfully cure one patient. In addition, tetracycline (7) and minocycline (18) have been recommended although their clinical efficacy have not been estabUshed. No proven therapeutic agents exist for treating A.catbamoeba infections, however, the phenothiazines, trifluoperazine [117-89-5] and chlorpromazine [50-53-3], show promise in vitro. 

Minocycline is an effective alternative to rifampin for eradication of meningococci, including sulfonamide-resistant strains, from the nasopharynx. However, the high incidence of dose-related vestibular side effects renders it less acceptable. Although minocychne has good in vitro activity against Nocardia spp., further studies are necessary to confirm its clinical efficacy. 

Minocycline, 200 mg orally daily for 5 days, can eradicate the meningococcal carrier state, but because of side effects and resistance of many meningococcal strains, rifampin is preferred. Demeclocycline inhibits the action of antidiuretic hormone in the renal tubule and has been used in the treatment of inappropriate secretion of antidiuretic hormone or similar peptides by certain tumors (see Chapter 15). 

M ulcerans Skin ulcers Isoniazid, streptomycin, rifampin, minocycline (Surgical excision may be effective.)... 

Not all mycobacterial infections are caused by M. tuberculosis or M. leprae. These atypical mycobacteria require treatment with secondary medications as well as other chemotherapeutic agents. For example, M. marinum causes skin granulomas, and effective drugs in the treatment of infection are rifampin or minocycline. Mycobacterium fortuitum causes skin ulcers and the medications recommended for treatment are ethambutol, cycloserine, and rifampin in combination with amikacin. 

Clinically important, potentially hazardous interactions with alprazolam, amiodarone, amphotericin B, arbutamine, bendroflumethiazide, benzthiazide, bisacodyl, bumetanide, carbimazole, chlorothiazide, chlorthalidone, cholestyramine, clarithromycin, conivaptan, cyclosporine, cyclothiazide, dan-shen, demeclocycline, devil s claw, dexmedetomidine, doxycycline, erythromycin, esomeprazole, ethacrynic acid, flunisolide, furosemide, ginseng, glycopyrrolate, glycopyrronium, hawthorn (fruit, leaf, flower extract), horsetail, hydrochlorothiazide, hydroflumethiazide, indapamide, licorice, lopinavir, mepenzolate, methyclothiazide, metolazone, minocycline, mistletoe, oxprenolol, oxytetracycline, paroxetine, phenylbutazone, polythiazide, propafenone, propantheline, quinethazone, quinidine, rabeprazole, rifampin, roxithromycin, sarsaparilla, senna, Siberian ginseng, squill, St John s wort, telithromycin, teriparatide, tetracycline, thiazide diuretics, tolvaptan, trichlormethiazide, verapamil... 

Furthermore, the antifungal actions of amphotericin B are enhanced by flucytosine, minocycline, or rifampin, agents otherwise devoid of antifungal activity. 

Rea, T. H. (2000). Trials of daily, long-term minocycline and rifampin or clarithromycin and rifampin in the treatment of borderline lepromatous and lepromatous leprosy. Int. J. Lepr. Other Mycobact. Dis. 68, 129-135. 

M. marinum Rifampin -1- ethambutol Trimethoprim- sulfamethoxazole clarithromycin minocycline doxycycline... 

M. leprae Dapsone -1- rifampin + clofazimine Minocycline moxifloxacin or gatifloxacin clarithromycin ethionamide... 

A combination of rifampin and ethambutol is probably effective minocycline or tetracycline is active in vitro and is used by some physicians. M. scrofulaceum is an uncommon cause of cervical lymphadenitis that is treated with surgical excision. Microbes of the M. fortuitum complex (including Mycobacterium chelonae) may cause chronic lung disease and infections of skin and soft tissues. The microorganisms are highly resistant to most drugs, but amikacin, cefoxitin, and tetracyclines are active in vitro. 

Patients with a small population of bacteria (i.e., with tuberculoid disease) should be treated with dapsone, 100 mg daily, plus rifampin, 600 mg once monthly fora minimum of 6 months. The regimen is repeated if relapse occurs. Single-dose multidrug therapy with rifampin (600 mg), ofloxacin (400 mg), or minocycline (100 mg) also may be as effective. 

Raad, 1.1., Darouiche, R. O., Dupuis, J., Abi-Said, D., Gabrielli, A., Hachem, R., Wall, M., Harris, R., Jones, J., Buzaid, A., et al., Central venous catheters coated with minocycline and rifampin for the pevention of catheter-related colonization and bloodstream infections. A randomized, double-blind trial. The Texas Medical Center Catheter Study Group, Ann. Intern. Med., 1997 127(4) 267-274. 

Prolonged course of minocycline or ethambutol and/or rifampin (Edelstein 1994 Kullavanijaya et al. 1993)... 

Rupp ME, Lisco SJ, Lipsett PA, et al. Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections a randomized, controlled trial. Ann Intern Med October 2005 143(8) 570-80. Darouiche RO, Raad II, Bodey GP, et al. Antibiotic susceptibility of staphylococcal isolates from patients with vascular catheter-related bacteremia potential role of the combination of minocycline and rifampin. Int J Antimicrob Agents September 1995 6(l) 31-6. 

Raad I, Darouiche R, Hachem R, et al. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J Infect Dis February 1996 173(2) 418-24. Darouiche RO, Raad II, Heard SO, et al. A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group. N EnglJ Med January 1999 340(l) l-8. 

Leon C, Ruiz-Santana S, ReUo J, et al. Benefits of minocycline and rifampin-impregnated central venons catheters. A prospective, randomized, double-blind, controlled, multicenter trial. Intensive Care Med October 2004 30(10) 1891—9. 

Raad 11, Daroniche RO, Hachem R, et al. Antimicrobial durability and rare ultrastructural colonization of indwelling central catheters coated with minocycline and rifampin. Crit... 

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