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Trials controlled

This compound has antihistaminic activity and is usehil in the therapy of motion sickness. It may also be effective in the control of post-operative nausea and vomiting. It is classified as FDA Category B for Pregnancy, ie, no demonstrated risks shown in animal studies however, no controlled trials in pregnant women. Large doses may cause drowsiness and dry mouth owing to decreased secretion of saUva. [Pg.204]

Quinn, J., Drzewiecki, A., Li, M., Stiell, I., Sutcliffe, T., Elmsiie, T. and Wood, W., A randomized, controlled trial comparing a tissue adhesive with suturing in the repair of pediatric facial lacerations. Ann. Emerg. Med., 22, 1130-1135 (1993). [Pg.1126]

Chapman, W., Sherman, R., Boyce, S., Malawer, M., Hill, A., Buncke, G., Block, J., Fung, J., Clavien, R, Lee, K., Lebovic, G., Wren, S., Diethrich, E. and Goldstein, R., A novel collagen-based composite offers effective hemostasis for multiple surgical indications Results of a randomized controlled trial. Surgery, 129, 445-450 (2001). [Pg.1128]

It should be noted that it is extremely difficult to predict service lives of buried pipelines from the results of controlled trials with small specimens, whether in the laboratory or in the field. For example a study on the comparative corrosion resistances of ductile and grey iron pipes carried out jointly by European pipemakers in 1964-1973 indicated a mean pitting rate of 0 -35 mm/y for uncoated ductile iron pipe exposed in a typical heavy Essex clay of 500-900 ohm cm resistivity for 9 years. This is clearly at odds with the rate of 1 mm/y normally found on a corroded service pipe from such a soil. The discrepancy appears to be due to the use of specimens that were only a third of a pipe length each and were buried separately. It may reflect the contribution of the total surface area of the pipe as a cathode to the corrosion current at the anodic area at the pitting site. [Pg.593]

Writing Group for the Women s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women principal results from the Women s Health Initiative randomized controlled trial. JAMA 288 321-333... [Pg.393]

In low doses, inhaled NO may have a beneficial therapeutic effect, since NO in the inspired air leads to pulmonary vasodilation. In persistent pulmonary hypertension of the newborn, NO inhalation has already been used with some success. NO inhalation as the treatment for acute respiratory distress syndrome, however, has been disappointing. Only transient improvements of oxygenation were detected and the outcome of placebo-controlled trials did not show any improvement... [Pg.575]

Sano M, Ernesto C, Thomas RG et al (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer s disease. The Alzheimer s Disease Cooperative Study. N Engl JMed 336 1216-1222... [Pg.1298]

Quite separately, the results of a properly controlled trial were published in a 1974 paper entitled Electrostatic Descaler Testing an Evaluation (Meckler, M., Heating/Piping/Air Conditioning, Reinhold Publishing Co.). This paper concluded that the test descaler was not effective in preventing scale deposition, and we were unable to detect any measurable reduction in corrosion potentials. ... [Pg.337]

Dorus and colleagues (1989) conducted a multicenter, double-blind, placebo-controlled trial in depressed and nondepressed alcoholic veterans. A total of 457 male alcoholic patients, of whom approximately one-third were depressed, were randomly assigned to receive either 600-1,200 mg/day of lithium or a comparable number of placebo capsules. No significant differ-... [Pg.38]

Fawcett J, Clark DC, Aagesen CA, et al A double-blind, placebo-controlled trial of lithium carbonate therapy for alcoholism. Arch Gen Psychiatry 44 248-2 56,1987... [Pg.44]

Johnson BA, Ait-DaoudN Neuropharmacological treatments for alcoholism scientific basis and clinical findings. Psychopharmacology (Berl) 149 327—344, 2000 Johnson BA, Roache JD, Javors MA, et al Ondansetron for reduction of drinking among biologically predisposed alcoholic patients a randomized controlled trial. [Pg.46]

Kranzler HR, Del Boca F, Korner P, et ah Adverse effects limit the usefulness of flu-voxamine for the treatment of alcoholism.] Subst Abuse Treat 10 283-287, 1993 Kranzler HR, Burleson JA, Del Boca FK, et ah Buspirone treatment of anxious alcoholics a placebo-controlled trial. Arch Gen Psychiatry 31 720—731, 1994 Kranzler HR, Burleson JA, Korner P, et ah Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics. Am] Psychiatry 152 391-397, 1995 Kranzler HR, Burleson JA, Brown J, et al Fluoxetine treatment seems to reduce the beneficial effects of cognitive-behavioral therapy in type B alcoholics. Alcohol Clin Exp Res 20 1534-1341, 1996... [Pg.48]

Malcolm R, Ballenger JC, Sturgis ET, et ah Double-blind controlled trial comparing carbamazepine to oxazepam treatment of alcohol withdrawal. Am J Psychiatry 146 617-621, 1989... [Pg.49]

Malcolm R, Anton RF, Randall CL, et al A placebo-controlled trial of Buspirone in anxious inpatient alcoholics. Alcohol Clin Exp Res 16 1007—1013, 1992... [Pg.49]

Streeton C, Whelan G Naltrexone, a relapse prevention maintenance treatment of alcohol dependence a meta-analysis of randomized controlled trials. Alcohol Alcohol 36 544-552, 2001... [Pg.53]

Dean AJ, Bell J, Mascord DJ, et al A randomized, controlled trial of fluoxetine in methadone maintenance patients with depressive symptoms. J Affect Disord 72 ... [Pg.98]

McRae AL, Sonne SC, Brady KT, et al A randomized, placebo-controlled trial of buspirone for the treatment of anxiety in opioid-dependent individuals. Am J Addict 13 53-63, 2004... [Pg.104]

Nestler EJ, Hyman SE, Malenka RC Molecular Neuropharmacology A Foundation for Clinical Neuroscience. New York, McGraw Hill, 2001 Novick DM, Pascarelli EE, Joseph H, et al Methadone maintenance patients in general medical practice a preliminary report. JAMA 259 3299—3302, 1988 Nunes EV, Quitkin EM, Donovan SJ, et al. Imipramine treatment of opiate-dependent patients with depressive disorders a placebo-controlled trial. Arch Gen Psychiatry 55 153-160, 1998... [Pg.105]

Seecof R, Tennant FS Subjective perceptions to the intravenous rush of heroin and cocaine in opioid addicts. Am J Drug Alcohol Abuse 12 79—87, 1987 Sees KL, Delucci KL, Masson C, et al Methadone maintenance vs. 180-day psycho-socially enriched detoxification for treatment of opioid dependence a randomized controlled trial. JAMA 283 1303-1310, 2000 Sells SB Treatment effectiveness, in Handbook on Drug Abuse. Edited by Dupont RE, Goldstein A, O Donnell J. Washington, DC, U.S. Government Printing Office, 1979, pp 105-118... [Pg.107]

Strang J, Bearn J, Gossop M Lofexidine for opiate detoxification review of recent randomized and open controlled trials. Am J Addict 8 337—348, 1999... [Pg.108]

Other anticonvulsants, such as gabapentin and topiramate, are also being used by some clinicians, but controlled trials are lacking. [Pg.136]

Oude Voshaar RC, Gorgels WJ, Mol AJ, et al Tapering off long-term benzodiazepine use with or without group cognitive-behavioural therapy three-condition, randomised controlled trial. Br J Psychiatry 182 498-304, 2003 Parry HJ, Balter MB, Mellinger GD, et al National patterns of psychotherapeutic drug use. Arch Gen Psychiatry 28 18-74, 1973... [Pg.158]

Cornelius JR, Salloum IM, EhlerJG, et al Fluoxetine in depressed alcoholics a doubleblind, placebo-controlled trial. Arch Gen Psychiatry 54 700—705, 1997 Cornelius JR, Salloum IM, Haskett RF, et al Fluoxetine versus placebo for the marijuana use of depressed alcoholics. Addict Behav 24 111—114, 1999 Cui S-S, Bowen RC, Gu G-B, et al Prevention of cannabinoid withdrawal syndrome by lithium involvement of oxytocinergic neuronal activation. J Neurosci 21 9867— 9876, 2001... [Pg.177]

Jorenby DE, Leischow SJ, Nides MA, et al A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Eng J Med 340 685— 691, 1999... [Pg.179]

Catecholamine Reserpine, propranolol, and other p blockers Placebo-controlled trial of reserpine had negative... [Pg.196]

Kranzler HR, Bauer LO, Hersh D, et al Carbamazepine treatment of cocaine dependence a placebo-controlled trial. Drug Alcohol Depend 38 203-211, 1995 Levin FR, Lehman AF Meta-analysis of desipramine an adjunct in the treatment of cocaine addiction. J Clin Pharmacol 11 374-378, 1991 Lima MS, Reisser AA, Soares BG, et al Antidepressants for cocaine dependence. Cochrane Database Syst Rev 4 CD002950, 2001 Ling W, Shoptaw S, Majewska D Baclofen as a cocaine anti-craving medication a preliminary clinical study 0etter). Neuropsychopharmacology 18 403 04, 1998... [Pg.206]

Nimmerrichter AA, Walter H, Gutierrez-Lobos KE, et al Double-blind controlled trial of gamma-hydroxybutyrate and clomethiazole in the treatment of alcohol withdrawal. Alcohol 37 67—73, 2002... [Pg.265]

Johnson BA, Roache JD, Javors MA, et al Ondansetron for reduction of drinking among biologically predisposed alcoholic patients a randomized controlled trial. [Pg.308]

Johnson BA, Ait-Daoud N, Bowden CL, et al Oral topiramate for treatment of alcohol dependence a randomised controlled trial. Lancet 361 (9370) 1677-1685, 2003... [Pg.308]

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