Lymphocytic leukemia system

Leurosine A( b-oxide (12) was found to be highly cytotoxic in the KB test system (ED,o 0.019 j.g/ml) in vitro, but, more importantly, activity was also observed in two in vivo systems. In the P388 lymphocytic leukemia system, at doses in the range 4.0-32.0 mg/kg, either on day 1 or on days 1-9, typical test/control values were in the range of 160-180%. Exceptional activity was observed in the B16 melanoma test system. 

Oxoleurosine (14) was evaluated for antitumor activity according to established protocols. No activity was observed in the dose range 0.25-6.25 mg/kg in the P388 lymphocytic leukemia system in mice, but the alkaloid was cytotoxic in the KB test system in vitro (EDjo 0.31 p.g/ml) (52). 

The bryostatins have been evaluated against the P388 lymphocytic leukemia system (72) giving in vitro ED50 values ranging from 0.89 (ig/ml to 1.8 10 5 pg/ml representing a factor of 50,000 in potency. 

At the request of Health and Welfare Canada, the U.S. National Cancer Institute conducted animal tests on a sample submitted by Resperin Corp. In a mouse lymphocytic leukemia system, essiac showed no activity, but it did show toxicity at the highest levels tested. ... 

The electronic spectra and magnetic susceptibility of [Ni(21)Cl2] were found to be consistent with a five-coordinate high spin complex. This complex has greater antitumor activity against P388 lymphocytic leukemia test system in mice than cobalt(II), copper(II), zinc(II) and platinum(II) complexes of 21 [187],... 

Although 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, 22, also forms [Ni(22)Cl2] with chemical properties similar to [Ni(21)Cl2], it, along with other metal complexes of 22, showed no activity against P388 lymphocytic leukemia test system in mice [202]. 

A series of paramagnetic [NiL-2H] complexes have been isolated in which L = 2,6-diacetylpyridine bis(azacyclothiosemicarbazones) with Ni(II) assuming a distorted five-coordinate structure with d-d bands at about 7250, 10510, 12500, 14400, 19200 and 20500 cm [153], None of these Ni(II) complexes were reported to have activity against the P388 lymphocytic leukemia test system in mice. 

Compare the classification systems for acute lymphocytic leukemia (ALL) and acute nonlymphocytic leukemia (ANLL). 

Because the risk of central nervous system (CNS) involvement is high, regardless of cerebrospinal fluid (CSF) cytology all patients with acute lymphocytic leukemia (ALL) receive intrathecal prophylaxis. 

TGN1412 (CD28-SuperMAb) is a humanized monoclonal antibody that binds and acts as an agonist for the CD28 receptor of the immune system s T cell. It is intended to treat B cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis. 

The association between malaria and Burkitt s lymphoma, and between splenomegaly and chronic lymphocytic leukemia are perhaps the results of the long-term effects of an overworked thymolymphatic system. 

Malignancies of various types— multiple myelomatosis, Waldenstrom macroglobulinemia, chronic lymphocytic leukemia, reticulum cell sarcoma, Hodgkin s disease, Burkitt s lymphoma and other malignancies of the reticuloendothelial system... 

A Cell Culture System That Mimics Chronic Lymphocytic Leukemia Cells Microenvironment for Drug Screening and Characterization... 

CHF congestive heart failure CHI closed head injury CLA cis-linoleic acid CLL chronic lymphocytic leukemia CML chronic myelogenous leukemia CMV cytomegalovirus CNS central nervous system Comps complications COMT catechol-O-methyltransferase Contra contraindicated COPD chronic obstructive pulmonary disease COX cyclooxygenase CP chest pain... 

Ansamycin antibiotics are probably the most complex organic compounds produced by the genus Streptomyces. In addition to the antibacterial, they also exhibit antiviral effects. Ansamitocin P-3 shows a potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. The compound exhibits a significant activity against P-388 lymphocytic leukemia in mice and both 9PS (murine lymphocytic leukemia) and 9KB (human nasopharyngeal carcinoma) in cell culture systems. [38]. 

Daphneticin (12), isolated from Daphne tangutica, showed cytotoxic activity against Walker carcinosarcoma ascites cells (68) but was inactive against KB cells (68). In vitro studies showed cleomiscosin A (9), isolated from the chloroform extract of Brucea javanica, to be active against the murine P-388 lymphocytic leukemia cell line (EDsq = 0.4 pg ml ), but inactive against the KB test system (57). Luyengi et al. reported the lack of activity of the same compound when evaluated against HL-60 human promyelocytic leukemia cells (59). 

Significant reductions in lymphocyte concentration (<1000/mm of blood) can be evident without apparent cause or in a variety of diseases, including acute inflammatory disorders, severe uremia, immune deficiency diseases such as systemic lupus erythematosus, chronic infections such as tuberculosis or human immunodeficiency virus (HIV) infection, malignancies, and connective tissue diseases. Lymphocytosis (>4000/mm ) may occur with mononucleosis, pertussis, measles, or chickenpox, and in lymphoid malignancies. A progressive increase in mature lymphocytes may be indicative of chronic lymphocytic leukemia. Increased levels of atypical lymphocytes may occur in patients with infections (e.g., mononucleosis, hepatitis, or cytomegalovirus), allergic reactions, or lymphomas." ... 

ALL, acute lymphocytic leukemia APL, acute promyelocytic leukemia CL, creatinine clearance CNS, central nervous system HD, Hodgkin s disease KS, Kaposi s sarcoma NHL, non-Hodgkin s lymphoma NSCLC, non-small-cell lung cancer. 

TABLE 132—3. Rai Staging System for Chronic Lymphocytic Leukemia... 

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