Brucea javanica

Noorshahida A, Wong TW, Choo CY. (2009) Hypoglycemic effect of qnassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds. J Ethnopharmacol 124 586-591. 

Canthin-6-ones Ailanthus altissima Brucea javanica... 

Quassinoids —The antileukaemic activity of some quassinoids has revived interest in this group. Three new biologically active compounds have been isolated. Quassimarin (118) occurs in Quassia amara with the inactive simalikalactone D (129) 86 Bruceoside A, from Brucea javanica, is the glucoside (120). The third... 

Brucea javanica (L.) Merrill B. sumatrana Roxb. Ya Dan Zi (Kosam seed) (fruit) Bruceines, bruceolide, brusatol, oleic acid, yatanoside.33-510 This herb is toxic. Antiamebial, anticancer, antiprotoxoan. 

Simaroubaceae 15 a. Brucea javanica (57-59) 15b. Castela texana 60) 15c. Hannoa klaineana 61) 15d. Simaba multiflora 56, 62) 15e. Soulamea soulameoides (56)... 

Daphneticin (12), isolated from Daphne tangutica, showed cytotoxic activity against Walker carcinosarcoma ascites cells (68) but was inactive against KB cells (68). In vitro studies showed cleomiscosin A (9), isolated from the chloroform extract of Brucea javanica, to be active against the murine P-388 lymphocytic leukemia cell line (EDsq = 0.4 pg ml ), but inactive against the KB test system (57). Luyengi et al. reported the lack of activity of the same compound when evaluated against HL-60 human promyelocytic leukemia cells (59). 

Lee KH, Hayashi N, Okano M, Nozaki H, Juichi M (1984) Antitumor agents, 65. Brusatol and Cleomiscosin A, Antileukemic Principles from Brucea javanica. J Nat Prod 47 550... 

Fukamiya N, Okano M, Miyamoto M (1992) Antitumor Agents, 127. Bruceoside C, a New Cytotoxic Quassinoid Glucoside and Related Compounds from Brucea javanica. J Nat Prod 55 468... 

Luyengi L, Suh N, Fong HHS, Pezzuto JM, Kinghom AD (1996) A Lignan and Four Terpenoids from Brucea javanica that Induce Differentiation with Cultured HL-60 Promye-locytic Leukemia Cells. Phytochemistry 43 409... 

Lin, L. Z. Zhang, J. S. Chen, Z. L. Xu, R. S. Studies on chemical constituents of Brucea javanica (L.) Merr.l. Isolation and identification of bruceaketolic acid and other four quassinoids. Huaxue Xuebao, 1982, 40 73-7. ... 

L Luyengi, N Suh, HHS Fong, JM Pezzuto, AD. Kinghom. A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelo-cytic leukemia cells. Phytochem 43 409 12, 1996. 

Brucea javanica Merr. is a shrub, which is distributed from Southeast Asia to northern Australia having its seeds been used in the treatment of dysentery, malaria and cancer [20],... 

Seeds of Brucea javanica are known as Ya-dan-zi in Chinese folklore and have been used as a Chinese medicine for cancer, and the main active compounds of the plant has been extensively studied and thirty-four quassinoids have thus far isolated the last two decades. 

Eighteen quassinoids glycosides and nine known quassinoids isolated from Brucea javanica, Brucea cmtidysenterica and Ailanthus altissima were tested for inhibitory activity against HIV replication in H9 lymphocytic cells [103],... 

Forty-five quassinoids isolated from the three Simaroubaceous plants, Brucea javanica, Brucea antidysenterica and Picrasma ailanthoides, and fourteen isolated from Ailanthus altissima were tested for Okano et al. [106-108] for their inhibitory activities using a short-term in vitro assay of the EBV-EA activation induced by TP A in Raji cells. 

Recently, Kinghorn et al. [96] reviewed the anticancer agents discovered by activity-guided fractionation and they include seventy compounds from twenty-two plants. Only one lignan is cited in the review guaiacylglycerol-P-06 -(2-methoxy)cinnamyl alcohol ether isolated from Brucea javanica (Simaroubaceae) exhibited weak activity against the induction of cell differentiation of human promyelocytic leukemia (HL-60) cells [96,97],... 

---