Creams and lotions

Aerosols. Pressurized containers to deHver aerosolized dmg products through appropriate systems of valves and actuators have been available since the 1950s (see Aerosols). Such dosage forms are used as external appHcations of lotions and creams, for oral inhalation, or for treatment of the vaginal cavity, eg, contraceptive foams. Aerosols contain two- or three-phase systems, wherein a volatile Hquid or admixture of Hquids is sealed in a... 

If the dmg is not soluble in the propellant, it is dissolved or dispersed in a Hquid vehicle. The propellant then constitutes the third phase of the system, and the container must be shaken before valve actuation. Emulsified aerosol products like lotions and creams are examples of such systems. 

Emulsions of fatty- and petroleum-based substances, both oils and waxes, of the o/w type are made by using blends of sorbitan fatty esters and their poly(oxyethylene) derivatives. Mixtures of poly(oxyethylene(20)) sorbitan monostearate (Polysorbate 60) and sorbitan monostearate are typical examples of blends used for lotions and creams. Both sorbitan fatty acid esters and their poly(oxyethylene) derivatives are particularly advantageous in cosmetic uses because of their very low skin irritant properties. Sorbitan fatty ester emulsifiers for w/o emulsions of mineral oil are used in hair preparations of both the lotion and cream type. Poly(oxyethylene(20)) sorbitan monolaurate is useflil in shampoo formulations (see Hairpreparations). Poly(oxyethylene) sorbitan surfactants are also used for solubilization of essential oils in the preparation of colognes and after-shave lotions. 

Benzyl Chloride. Benzyl chloride is manufactured by high temperature free-radical chlorination of toluene. The yield of benzyl chloride is maximized by use of excess toluene in the feed. More than half of the benzyl chloride produced is converted by butyl benzyl phthalate by reaction with monosodium butyl phthalate. The remainder is hydrolyzed to benzyl alcohol, which is converted to ahphatic esters for use in soaps, perfume, and davors. Benzyl salicylate is used as a sunscreen in lotions and creams. By-product benzal chloride can be converted to benzaldehyde, which is also produced directiy by oxidation of toluene and as a by-product during formation of benzoic acid. By-product ben zotrichl oride is not hydrolyzed to make benzoic acid but is allowed to react with benzoic acid to yield benzoyl chloride. 

Most antiperspirant sticks are molded. Sticks dominate in the U.S. market, whereas lotion and cream antiperspirants are preferred in Europe. Stick antiperspirant products may include suspending agents, coupling agents to wet the antiperspirant chemical (about 20—25%), and emoUients. The blend is prepared at about 65°C and poured at about 55°C. Antiperspirant (64) and deodorant (65) compositions have been pubHshed. 

Perfumes, Flavors, Cosmetics, and Soap. Many naturally occurring esters in essential oils and some synthetic esters are important fragrance and flavor compounds (61,62). They are used in perfumes, flavors, cosmetics, soaps, detergents, and air fresheners. Benzyl, butyl, ethyl, methyl, and phenyl esters of benzoic acid are used as flavors, perfumes, and food preservatives. Glyceryl 4-aminobenzoate [136-44-7] and 2-ethyUiexyl 4-dimethylaminobenzoate [21245-02-3] are used in cosmetic sunscreen preparations. Alkyl esters of 4-hydroxybenzoic acid, called parabens, have been used under various names for fungus infections of the skin, and as preservatives in lotions and creams (101). Soap and cosmetic fragrances use large amounts of amyl and benzyl saHcylate. Benzyl saHcylate [118-58-1] is also used in deodorant sprays. 2-Ethylhexyl saHcylate [118-60-5] and 2-ethylhexyl 4-methoxycinnamate [5466-77-3] are used in sunscreen formulations (102). 

More elaborate sample preparation is often needed for complex sample matrices, e.g., lotions and creams. Many newer SP technologies such as solid-phase extraction (SPE), supercritical fluid extraction (SFE), pressurized fluid extraction, accelerated solvent extraction (ASE), and robotics are frequently utilized (see Ref. [2]). Dosage forms such as suppositories, lotions, or creams containing a preponderance of hydrophobic matrices might require more elaborate SP and sample cleanup, such as SPE or liquid-liquid extraction. 

Polyglyceryl-2- dipolyhydroxystearate Dehymuls PGPH W/O - emulsifier for lotions and creams MW => 3000 yellow, cloudy, viscous... 

The inclusion of the a routine microbial limit test in a marketed product stability protocol depends on the pharmaceutical dosage form. Typically, the test would be used only for nonsterile products, especially oral liquids, nasal sprays, and topical liquids, lotions, and creams that have sufficient water activity to support the growth of microorganisms. In contrast, tablets, powder- and liquid-filled capsules, topical ointments, vaginal and rectal suppositories, nonaqueous liquids and inhalation aerosols with a water activity too low to allow for the product to support the growth of microorganisms would not be routinely tested. 

Repellent activity. The lotions and creams containing coconut oil were efficient in protecting against Simulium damnosum bites . 

It is scabicide, pediculocide and antipruritic used in the form of lotion and cream. 

Eccleston GM. Functions of mixed emulsifiers and emulsifying waxes in dermatological lotions and creams. Colloid Surf A 1997 123-124, 169-182. 

Lotions and creams usually contain emollients, oils that provide a smooth lubricant effect when applied to the skin. The oleic phase (typically 20-40 volume% of the overall emulsion) contains such components as [907] ... 

An amber-yellow coloured oil with a pleasant characteristic odour. Particularly suited to greasy complexions as it rapidly penetrates the skin, having an astringent and circulatory stimulating effect in addition to its nutritive properties. When diluted with other carriers like sunflower or grapeseed the blend may benefit conditions like acne. Cosmetically hazelnut oil is used in sun filter lotions and creams, soaps, shampoos and other hair products. Its main fatty acids are oleic (70-84%), linoleic (9-19%) and stearic (1-4%). It has been reported to cause immunological urticaria (a skin condition also known as hives) and in common with other nut oils there is a possibility of anaphylactic shock. 

For example, the ring opening of ethylene oxide with a OH initiator affords an alkoxide nucleophile, which propagates the chain by reacting with more ethylene oxide. This process yields poly(etbylene glycol), PEG, a polymer used in lotions and creams. The many C-O bonds in these polymers make them highly water soluble. 

Emulsification is widely used in pharmaceutical products for external application such as lotions and creams, and in aerosol products to form foams. Semisolid emulsified formulations are discussed below. 

As dibutyl sebacate is an emollient ester, the personal care grade is recommended for use in cosmetics, hair products, lotions, and creams. 

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