Oxiconazole cream and lotion

The cream and lotion formulations contain the antifungal active compound oxiconazole nitrate. Both formulations are for topical dermatologic use only. The cream contains 10 mg oxiconazole per gram of cream in a white to off-white, opaque cream base of purified water USP, white petrolatum USP, stearyl alcohol NF, propylene glycol USP, polysorbate 60 NF, and cetyl alcohol NF, with benzoic 

Weighed quantity of emulsifying ointment is melted in another vessel, and propylparaben (0.15%) in dispersed in it (oily phase). 

The dispersion containing gum olibanum powder and methylparaben is also heated to the same temperature as that of emulsifying ointment. 

The aqueous dispersion containing gum olibanum powder is added to the molten emulsifying ointment, and the mixture is stirred continuously at 10,000 rpm for 1 hour using a homogenizer to obtain cream consistency. 

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