Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Leukotrien

The method has been applied in asymmetric and regioselective syntheses of several natural compounds. Two simple examples are the commercial syntheses of the gipsy moth hydrophobic sex attractant, disparlure (RE. Rossiter, 1981, 1985) and < mono-epoxidation of a diene in a leukotriene B4 synthesis (L.S. Mills, 1983). [Pg.125]

Prostaglandins belong to a group of compounds that because they are related to icosanoic acid [CH3(CH2)i8C02H)] are collectively known as icosanoids The other icosanoids are thromboxanes prostacyclins and leukotrienes... [Pg.1081]

The carbon sulfur bond in LTC4 is formed by the reaction of glutathione (Section 15 13) with leukotriene A4 (LTA4) LTA4 is an epoxide Sug gest a reasonable structure for LTA4... [Pg.1082]

Most of the drugs such as epinephrine and albuterol used to treat asthma attacks are bronchodilators—substances that expand the bronchial passages Newer drugs are designed to either inhibit the enzyme 5 lipoxygenase which acts on arachidomc acid m the first stage of leukotriene biosynthesis or to block leukotriene receptors... [Pg.1082]

Leukotrienes and Prostanoids. Arachidonic acid (AA) (213) and its metabohtes are iavolved ia cellular regulatory processes ia all three principal chemical signaling systems endocrine (see Hormones), immune, and neuronal (62). FoUowiag receptor activation or iacreased iatraceUular... [Pg.555]

Table 14. Prostanoid and Leukotriene Receptor Agonists and Antagonists... Table 14. Prostanoid and Leukotriene Receptor Agonists and Antagonists...
The first SRS-A antagonist, FPL-55712 (26) (149), was discovered before the stmctures of the leukotrienes were detemiined. Although this compound is relatively weak as an antagonist and suffers from a very short half-life in vivo, it played an important role both in leukotriene stmcture elucidation and as a model for later antagonists. In work stmcturaHy related to FPL-55712, LY-171883 was developed (27) (150). LY-171883 was evaluated in several clinical trials before development was stopped. Orally adrninistered, LY-171883 blocked slightly the response to aerosol LTD improved pulmonary function (FEV ) in mild asthmatics (151), decreased the sensitivity of asthmatics to cold air-induced bronchoconstriction (152), and significantly reduced the bronchoconstrictor response to inhaled antigen (153). However, in all these studies the beneficial effects were minimal. [Pg.445]

Detailed accounts of the biosynthesis of the prostanoids have been pubUshed (14—17). Under normal circumstances arachidonic acid (AA) is the most abundant C-20 fatty acid m vivo (18—21) which accounts for the predominance of the prostanoids containing two double bonds eg, PGE2 (see Fig. 1). Prostanoids of the one and three series are biosynthesized from dihomo-S-linolenic and eicosapentaenoic acids, respectively. Concentrations ia human tissue of the one-series precursor, dihomo-S-linolenic acid, are about one-fourth those of AA (22) and the presence of PGE has been noted ia a variety of tissues (23). The biosynthesis of the two-series prostaglandins from AA is shown ia Eigure 1. These reactions make up a portion of what is known as the arachidonic acid cascade. Other Hpid products of the cascade iaclude the leukotrienes, lipoxins, and the hydroxyeicosatetraenoic acids (HETEs). Collectively, these substances are termed eicosanoids. [Pg.151]

Endotoxin and Muramyl Dipeptide Derivatives. Bacterial cell wall constituents such as the Hpopolysaccharide endotoxin and muramyl dipeptide, which stimulate host defense systems, show radioprotective activity in animals (204). Although endotoxin is most effective when given - 24 h before irradiation, it provides some protection when adrninistered shortiy before and even after radiation exposure. Endotoxin s radioprotective activity is probably related to its Hpid component, and some of its properties may result from PG and leukotriene induction (204). [Pg.496]

Leukotrienes. Leukotrienes, products of the Hpoxygenase pathway, are generally less radioprotective than the PGs, with the exception of LTC4, which is among the most potent of the naturally occurring eicosanoids (214). LTC radioprotects V79 hamster cells in vitro and mouse CEU-S and... [Pg.497]

The organization of Part Two is according to structural type. The first section, Chapter Seven, is concerned with the synthesis of macrocyclic compounds. Syntheses of a number of heterocyclic target structures appear in Chapter Eight. Sesquiterpenoids and polycyclic higher isoprenoids are dealt with in Chapters Nine and Ten, respectively. The remainder of Part Two describes syntheses of prostanoids (Chapter Eleven) and biologically active acyclic polyenes including leukotrienes and other eicosanoids (Chapter Twelve). [Pg.99]


See other pages where Leukotrien is mentioned: [Pg.222]    [Pg.1082]    [Pg.1102]    [Pg.562]    [Pg.562]    [Pg.562]    [Pg.562]    [Pg.562]    [Pg.562]    [Pg.562]    [Pg.98]    [Pg.203]    [Pg.139]    [Pg.142]    [Pg.106]    [Pg.556]    [Pg.556]    [Pg.559]    [Pg.561]    [Pg.312]    [Pg.388]    [Pg.444]    [Pg.444]    [Pg.444]    [Pg.444]    [Pg.444]    [Pg.444]    [Pg.444]    [Pg.445]    [Pg.445]    [Pg.445]    [Pg.447]    [Pg.438]    [Pg.497]    [Pg.498]    [Pg.36]    [Pg.101]   
See also in sourсe #XX -- [ Pg.4 ]




SEARCH



11 -Leukotrienes, mechanism

11 -Leukotrienes, mechanism formation

Allergic reactions, leukotriene

Allergic reactions, leukotriene synthesis

Allergic rhinitis leukotriene receptor antagonists

Allergy processes role of leukotrienes

Application Epoxides, Leukotrienes, and Asthma

Arachidonic acid leukotriene biosynthesis from

Arachidonic acid leukotrienes derived from

Arachidonic acid leukotrienes from

Arachidonic acid, leukotriene

Arachidonic acid, leukotriene synthesis

Asthma leukotriene

Asthma leukotriene receptor antagonists

Asthma, leukotrienes

B-Leukotriene

Biological effects of, leukotrienes

Biological effects of, leukotrienes smooth muscle

Biology of Leukotrienes

Biosynthesis of leukotriene

Biosynthesis of leukotrienes

Biosynthesis of, leukotrienes occurrence

Biosynthesis of, leukotrienes purification

Bronchodilators leukotriene antagonists

Cysteinyl leukotriene

Cysteinyl leukotriene antagonist

Cysteinyl leukotriene antagonist Zafirlukast

Cysteinyl leukotrienes

Cysteinyl leukotrienes basophils

Cysteinyl leukotrienes biosynthesis

Cysteinyl leukotrienes isolation

Cysteinyl-leukotriene inhibitors

Development of Leukotriene A4 Hydrolase Inhibitors

Eosinophils and Leukotrienes

Fatty Acid and Leukotriene Monooxygenases

HAPTER TWELVE eukotrienes and Other Bioactive Polyenes 1 Formation of Leukotrienes from Arachidonic Acid

Histamine/peptide leukotriene

Hormones leukotrienes

Human cysteinyl leukotriene receptors

Immune regulation leukotrienes

Inflammation leukotrienes

Inflammation mediators leukotrienes

Inflammation role of leukotrienes

LTA4 (leukotriene

LTA4, leukotriene epoxide

LTB4 (leukotriene

LTC4 (leukotriene

Leukemia Leukotriene

Leukotrien synthesis

Leukotriene

Leukotriene , biosynthesis

Leukotriene A hydrolase

Leukotriene A4 hydrolase

Leukotriene A4 hydrolase inhibitors

Leukotriene A4 methyl ester, synthesis Lewis acids

Leukotriene A4 methyl ester, synthesis as catalysts for Diels-Alder reaction

Leukotriene A4 methyl ester, synthesis enantioselective induction

Leukotriene A4 methyl ester, synthesis general aspects of catalysis

Leukotriene A4 synthase

Leukotriene B4 (

Leukotriene B4 12-hydroxydehydrogenase

Leukotriene B4 antagonists

Leukotriene B4 production

Leukotriene B4 receptor

Leukotriene B4 receptor antagonists

Leukotriene C4 synthase

Leukotriene C4 synthetase

Leukotriene D, 5-deoxyprecursor synthesis

Leukotriene D, 5-deoxyprecursor synthesis via sulfoxide-sulfenate rearrangement

Leukotriene D4 antagonist

Leukotriene E4 (

Leukotriene LTA

Leukotriene LTA4, biosynthesis

Leukotriene LTD4 receptor antagonist

Leukotriene antagonists

Leukotriene antagonists Theophylline

Leukotriene antagonists Zafirlukast

Leukotriene antagonists adverse effects

Leukotriene antagonists asthma

Leukotriene antagonists studies

Leukotriene antagonists, metabolism

Leukotriene antagonists/inhibitors

Leukotriene biological actions

Leukotriene biosynthesis inhibition

Leukotriene biosynthesis inhibitors

Leukotriene biosynthesis of by 5-lipoxygenase

Leukotriene cardiovascular effects

Leukotriene catabolism

Leukotriene discovery

Leukotriene effect

Leukotriene endotoxin

Leukotriene gene polymorphisms

Leukotriene in asthma

Leukotriene inhibitors

Leukotriene inhibitory action

Leukotriene intermediates

Leukotriene modifiers

Leukotriene modulators

Leukotriene nomenclature

Leukotriene pathway

Leukotriene pathway inhibitors

Leukotriene receptor antagonists

Leukotriene receptor antagonists Churg-Strauss syndrome

Leukotriene receptor antagonists in asthma

Leukotriene receptor antagonists toxicity

Leukotriene receptors

Leukotriene receptors, cysteinyl

Leukotriene structures

Leukotriene sulphidopeptide

Leukotriene synthesis

Leukotriene synthesis LTB4 stereoisomers

Leukotriene synthesis desoxy LTD

Leukotriene synthesis from arachidonic acid

Leukotriene synthesis inhibitor

Leukotriene synthesis of analogs

Leukotriene synthesis of intermediate

Leukotriene via organocopper reagents

Leukotrienes

Leukotrienes

Leukotrienes (LTC4, LTD4, and

Leukotrienes A4 hydrolase inhibitors

Leukotrienes LTC4 type

Leukotrienes LTD4 type

Leukotrienes LTE4 type

Leukotrienes Wittig reaction

Leukotrienes activation

Leukotrienes alveolar

Leukotrienes and lipoxins

Leukotrienes and macrophages

Leukotrienes antagonists

Leukotrienes as pain mediator

Leukotrienes biological activity

Leukotrienes biosynthesis

Leukotrienes biosynthesis inhibitors

Leukotrienes clinical significance

Leukotrienes detection

Leukotrienes discovery

Leukotrienes effects

Leukotrienes functions

Leukotrienes hemodynamic effects

Leukotrienes history

Leukotrienes in asthma

Leukotrienes in inflammation

Leukotrienes inhibition

Leukotrienes leukotriene

Leukotrienes leukotriene

Leukotrienes lipoxins

Leukotrienes metabolism

Leukotrienes model

Leukotrienes modifiers

Leukotrienes neutrophil recruitment

Leukotrienes physiologic effects

Leukotrienes physiological effects

Leukotrienes receptor

Leukotrienes receptor antagonists

Leukotrienes receptor blockers

Leukotrienes regulation

Leukotrienes role in allergy processes

Leukotrienes role in inflammation

Leukotrienes semi-synthesis

Leukotrienes structure

Leukotrienes structure proof

Leukotrienes via D-arabinose

Leukotrienes via sulfur ylide reagents

Leukotrienes, Prostaglandins and Related

Leukotrienes, Prostaglandins and Related ompounds

Leukotrienes, inhibitors

Leukotrienes, inhibitors cysteinyl

Leukotrienes, synthesis

Leukotriens, role

Lipoxygenase reaction products leukotrienes

Mast cell leukotrienes

Nomenclature leukotrienes

Of leukotriene

Pain mediator leukotrienes

Peptide-leukotriene antagonists

Peptido-leukotrienes

Peptido-leukotrienes receptors

Pharmacogenomics of Leukotrienes in Asthma

Polyunsaturated fatty acids leukotriene

Prostaglandins and Leukotrienes

Prostaglandins and leukotriene biosynthesis

Prostaglandins, Leukotrienes, and Lipoxins

Prostaglandins, Leukotrienes, and Other Eicosanoids

Prostaglandins, thromboxanes and leukotrienes

Separation of leukotrienes by HPLC

Structure of leukotriene

The Leukotriene Receptors

The leukotrienes

© 2024 chempedia.info