Inhibitor leukotriene

Finally there has been a growing interest in the development of selective leukotriene inhibitors. Bay Y 1015 (R-(-)-2-cycloheptyl-N-methylsulfonyl-(4-(2-quinolinyl-methoxy) phenyl)-acetamide) is a quinoline-type 5-lipoxygenase-activating protein inhibitor which was effective in inhibiting inflammation in a dextran sulfate model of mouse colitis [112]. Whether these compounds can also exert their anti-inflammatory action through inhibition of endothelial cell activation needs to be established. 

Mectianism of Action A leukotriene inhibitor that inhibits the enzyme responsible for... 

Krawiec ME, Wenzel SE Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma. Exp Opin Invest Drugs 2001 2 47. [PMID 11336568]... 

Evidence also suggests that leukotriene inhibitors can be combined with other drugs (glucocorticoids, beta agonists) to provide optimal management in specific patients with asthma and COPD.11,60 In particular, it appears that these drugs may enhance the anti-inflammatory effects of glucocorticoids, and may therefore provide therapeutic effects at a relatively... 

Leukotriene inhibitors are safer than other antiinflammatory agents such as the glucocorticoids. Some hepatic impairment has been reported with these drugs, but cases of severe toxicity are relatively rare. 

Inhaled glucocorticoids are therefore the cornerstone of drug therapy for patients with asthma. Leukotriene inhibitors, beta agonists, and theophylline can be used to supplement glucocorticoids as needed, with the specific drug regimen determined on... 

Aerosol 100 g/puff in 240 dose container Leukotriene Inhibitors Montelukast (Singulair)... 

Leukotriene inhibitors, one leukotriene inhibitor blocks leukotriene synthesis by inhibiting the action of 5-lipooxygenase (Zileuton Zyflo). Another blocks leukotriene receptors on the surface of smooth-muscle cells and eosinophils (Montelukast Singulair). 

A key observation that would impact the design of new FLAP inhibitors was that an older leukotriene inhibitor, Rev-5901 (15),... 

For example, substantial R D activity is currently underway in several pharmaceutical companies to develop new asthma therapies based on leukotriene inhibitors (403). A total of 25 compounds are now under investigation. How the research will proceed, which research programs will yield products that can be tested in... 

Analogous P450-catalyzed dehydrogenations have been invoked in the mechanism-based inactivation of select P450 isoforms by the pulmonary toxin 3-methylindole , the anticonvulsant valproic acid (see Chapter 6) , and the leukotriene inhibitor zafirlukast (Figure 7.25) . 

Burghuber, O., Strife, R., Zirrolli, J., Mathias, M., Henson, J., Henson, P., Reeves, J., Murphy, R. and Voelkel, N. (1984). Leukotriene inhibitors attenuate H202-induced rat lung injury. Am. Rev. Respir. Dis., 129, A333... 

More important, blood eosinophilia (i.e, >1.5 x 10 eosinophils/L) is present in a subset of asthmatics in the absence of any determined cause, defining so-called hypereosinophilic asthma, which should raise concern of an increased risk of evolution to ICEP or systemic disease such as CSS. We discourage the use of leukotriene inhibitors in this context as these drugs have... 

Leukotriene inhibitors have been extensively used in the treatment of asthma and may be associated with the development of Churg-Slrauss syndrome including pulmonary infiltrates, eosinophilia, and cardiac dysfunction, though this relationship is controversial and not definitively established. These manifestations have been attributed to the discontinuation of systemic or inhaled steroids leading to a flare of a previously cUnically silent vasculitis rather than to the leukotriene inhibitors themselves (22). 

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