Cysteinyl leukotrienes isolation

Thompson, M. D., Capra, V., Takasaki, J., et al. (2007) A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate. Pharmacogenet. Genomics. 17, 539-549. 

Fauler J, Wiemeyer A, Yoshizawa M, Schurek HJ, Frolich JC Metabolism of cysteinyl leukotrienes by the isolated perfused rat kidney. Prostaglandins 42 239-49,1991... 

L stimulates in vitro the release of preformed and de novo synthesized vasoactive and proinflammatory mediators (histamine, tryptase and cysteinyl leukotriene) by human mast cells isolated from heart tissue [45], As shown in figure 1, protein L binds ex vivo to B cells expressing human k L-chain-positive Igs. 

Originally isolated after stimulation of lung tissue by histamine and snake venom and named over 70 years ago as slow reacting substance of anaphylaxis, (SRS-A), leukotrienes are a family of bioactive peptide-conjugated eicosanoid lipids produced by mast cells, basophils, eosinophils, and macrophages. The name cysteinyl leukotrienes is derived from the facts that the com-... 

The isolation and chemical structure of SRS-A was finally achieved by the early 1980s They are the 6-glutathione and 6-cysteinyl derivatives of leukotriene C and D, LTC4, and LTD4 (see Fig. 5-5 and relevant discussion in Chapter 5). 

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