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Leukotriene B4 receptor antagonists

Wikel, J.H., Sofia, M.J., Saussy, D.L. and Bemis, K.G. (1994). QSAR Study of Ortho Phenylphe-nol Leukotriene B4 Receptor Antagonists. Bioorg.Med.Chem.Lett., 4, 795-800. [Pg.662]

A.fructus whole plant leukotriene B4 receptor antagonist ] 13... [Pg.861]

Synthesis of 2-, 4-, and 5-(2-alkylcarbamoyl-l-methylvinyl)-7-alkyloxy-benzo[h]furans and their leukotriene B4 receptor antagonistic activity 05YZ863. [Pg.35]

Chan and collaborators disclosed in 1993 three imidazole-based alkaloids bearing structural resemblance to the structure classes discussed above. Structures are given in Chart 3 [39]. Leucettamine A showed potent leukotriene B4 receptor antagonist activity, whereas leucettamine B was inactive. Leucettamidine also showed leukotriene antagonist activity. Leucettamine C was isolated in 2003 [47]. Clathridimine was isolated in 2010 [4]. The structure exhibited selective antibacterial activities against Escherichia coli and antifungal activity toward C. albicans. [Pg.55]

As part of studies directed at leukotriene B4 receptor antagonists, Djuric et al. [66] resolved the chromanone (44) by derivatization of the ketone functionality with Enders SAMP auxiliary [67] and separation of the resulting... [Pg.226]

Chan, G.W., Mong, S Hemling, M.E., Freyer, AJ., Offen, P.H., DeBrosse, C.W., Sarau, H.M., and Westley, J.W. (1993) New leukotriene B4 receptor antagonist leucettamine A and related imidazole alkaloids from the marine sponge Leucetta microraphis. ]. Nat Prod., 56,116-121. [Pg.1216]

Polmar, S., Diaz-Gonzalez, F., Dougados, M., Ortiz, P., and del-Miguel, G. (2004). Limited clinical efficacy of a leukotriene B4 receptor (LTBQ antagonist in patients with active rheumatoid arthritis (RA). Arthritis Rheum. 50 S239. [Pg.197]

The biological actions of the cysteinyl leukotrienes are mediated via stimulation of CysLTi receptors. Montelukast and zafirlukast are competitive antagonists of these receptors. In contrast, zileuton suppresses synthesis of the leukotrienes by inhibiting 5-lipoxygenase, a key enzyme in the bioconversion of arachidonic acid to the leukotrienes. Zileuton also blocks the production of leukotriene B4, another arachidonic acid metabolite with proinfiammatory activity. The CysLTi-receptor antagonists alter neither the production nor the actions of leukotriene B4. [Pg.466]

Leukotriene Antagonists. The leukotrienes are metabolites of arachidonic acid generated de novo after inflammatory cell activation [69,75] and are potent bronchoconstrictors and proinflammatory agents (vide supra). The biological effects of the cysteinyl-leukotrienes (viz. C4, D4, and E4) and of leukotriene B4 are mediated via cysLTi and BLT receptors, respectively [69,76]. The development of potent, selective cysLT receptor antagonists, such as montelukast, pranlukast,... [Pg.67]


See other pages where Leukotriene B4 receptor antagonists is mentioned: [Pg.118]    [Pg.49]    [Pg.288]    [Pg.74]    [Pg.187]    [Pg.148]    [Pg.288]    [Pg.277]    [Pg.118]    [Pg.49]    [Pg.288]    [Pg.74]    [Pg.187]    [Pg.148]    [Pg.288]    [Pg.277]    [Pg.705]    [Pg.320]    [Pg.815]    [Pg.118]    [Pg.394]    [Pg.907]    [Pg.166]    [Pg.63]    [Pg.740]    [Pg.468]    [Pg.487]   
See also in sourсe #XX -- [ Pg.74 ]

See also in sourсe #XX -- [ Pg.74 ]




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Leukotrien

Leukotriene B4 (

Leukotriene B4 antagonists

Leukotriene B4 receptor

Leukotriene antagonists

Leukotriene receptor antagonists

Leukotriene receptors

Leukotrienes

Leukotrienes leukotriene

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