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Development of Leukotriene A4 Hydrolase Inhibitors

IC50 (epoxide hydrolase activity) = 4 pM IC50 (epoxide hydrolase activity) = 14 pM [Pg.388]

CDK1/cyclin B IC60 = 0.033 pM CDK2/cyclin A IC60 = 0.033 pM [Pg.390]

The cofactors are structurally similar. The catalytic mechanisms of nucleotide kinases and sulfotransferases are also similar. [Pg.392]

The similarities concerning the bound cofactors, the reaction mechanism, and the adenine-binding pockets led to a screen of the above-described purine-based library of ATP-competitive inhibitors originally designed to target CDKs for crossreactivity with the carbohydrate sulfotransferase NodH from Rhizobium meliloti. [Pg.392]

PSSC based reanalysis of the development of leukotriene A4 hydrolase inhibitors... [Pg.72]

See other pages where Development of Leukotriene A4 Hydrolase Inhibitors is mentioned: [Pg.386]   


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Inhibitor development

Leukotrien

Leukotriene A4 hydrolase

Leukotriene A4 hydrolase inhibitors

Leukotriene inhibitors

Leukotrienes

Leukotrienes A4 hydrolase inhibitors

Leukotrienes leukotriene

Leukotrienes, inhibitors

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