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Leukotrienes A4 hydrolase inhibitors

PSSC based reanalysis of the development of leukotriene A4 hydrolase inhibitors... [Pg.72]

Davies DR, Mamat B, Magnusson OT et al (2009) Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J Med Chem 52 4694-4715... [Pg.31]

Sandanayaka V, Mamat B, Mishra RK et al (2010) Discovery of 4-[(2S)-2- [4-(4-chloro-phenoxy)phenoxy]methyl -l-pyrrolidinyl]butanoic acid (DG-051) as anovel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J Med Chem 53 573-585... [Pg.32]

Yuan JH, Birkmeier J, Yang DC, Hribar JD, Liu N, Bible R, Hajdu E, Rock M, Schoenhard G. Isolation and identification of metabolites of leukotriene A4 hydrolase inhibitor SC-57461 in rats. Drug Metab Dispos 1996 24 1124-1133. [Pg.367]

Leukotriene A4 hydrolase Inflammatory diseases DS CATALYST Inhibitor (IC50 = 8 nM) [127]... [Pg.138]

Wetterlholm A, Haeggstrom JZ, Samuelsson B, Yuan B, Munoz B, Wong CH. Potent and selective inhibitors of leukotriene A4 hydrolase effects on purified enzyme and human polymorphonuclear leukocytes. J Pharmacol Exper Ther 1995 275 31-37. [Pg.128]

See other pages where Leukotrienes A4 hydrolase inhibitors is mentioned: [Pg.386]    [Pg.150]    [Pg.386]    [Pg.150]    [Pg.72]    [Pg.5143]    [Pg.5142]    [Pg.385]   
See also in sourсe #XX -- [ Pg.386 , Pg.387 ]



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Development of Leukotriene A4 Hydrolase Inhibitors

Leukotrien

Leukotriene A4 hydrolase

Leukotriene A4 hydrolase inhibitors

Leukotriene A4 hydrolase inhibitors

Leukotriene inhibitors

Leukotrienes

Leukotrienes leukotriene

Leukotrienes, inhibitors

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